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Scientific Disciplinary Sector Code
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Contact Hours
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90322 -
Mathematics, physics and information technology
(objectives)
The Medical Statistics course aims to provide students with the basic notions of physics, statistics and computer science, the purpose of which is teaching the logic of statistical thinking and its application in real practice. The presentation of the topics will be oriented to concrete problems of analysis and research, starting from schematic examples and then confronting real situations taken from the medical literature.
The aim of the integrated course of Mathematical, Physical and Computer Science (Medical Physics, Medical Statistics and Computer Science) is to provide students with the knowledge on the foundations of applied physics necessary for the performance of their future activity, the principles of information technology and the principles of physical, applied to their professional profile. In particular, the understanding of the physical principles underlying medical physics and the functioning of medical instrumentation will be addressed.
At the end of the course, students will know the fundamental concepts of application of the scientific method to the study of biomedical phenomena (choice and measurement of parameters, evaluation of errors), they will be able to describe the physical phenomena of complex systems using appropriate mathematical tools, they will know the scientific bases of medical procedures and the operating principles of the equipment commonly used for diagnostics and therapy, as well as to provide the student with the skills necessary to understand the key role that Information Technology (IT) plays for today's society and, in in particular, within the technical-health professions.
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Medical physics
(objectives)
Aim of the course of Medical Physics within the integrated course of Mathematics, Physics and
Information Technology (Medical Physics, Medical Statistics and Informatics) is to provide students
with knowledge on the fundamentals of applied physics necessary to the performance of their
future activity. In particular, the comprehension of physical principles at the base of medical
physics and of functioning of medical instrumentation will be addressed.
At the end of the course, the students will know the fundamental concepts of application of the
Scientific Method to the study of biomedical phenomena (choice and measure of parameters,
evaluation of errors), they will be able to describe physical phenomena of complex systems using
suitable mathematical tools, they will know the scientific basis of medical procedures and
principles of functioning of the equipment commonly used for diagnostics and therapeutics.
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Indovina Iole
( syllabus)
Mechanics
Chapter 1: Introduction, Measurement, Estimating
1.4: Measurement and Uncertainty; Significant Figures
1.5: Units, Standards, and SI Units
1.6: Converting Units
1.8: Dimensions and Dimensional Analysis
Chapter 2: Describing Motion: Kinematics in One Dimension
2.1: References Frames and Displacement
2.2: Average Velocity
2.3: Instantaneous Velocity
2.4: Acceleration
2.5: Motion at Constant Acceleration
Chapter 3: Kinematics in Two Dimensions; Vectors
3.1: Vectors and Scalars
3.2: Addition of Vectors-Graphical Methods
3.3: Subtraction of Vectors and Multiplication of a Vector by a Scalar
3.4: Adding Vectors by Components
Chapter 4: Dynamics: Newton's Laws of Motion
4.1: Force
4.2: Newton's First Law of Motion
4.3: Mass
4.4: Newton's Second Law of Motion
4.5: Newton's Third Law of Motion
4.6: Weight-The Force of Gravity; and the Normal Force
4.7: Solving Problems with Newton's Laws: Free-Body Diagrams
4.8: Problems Involving Friction, Inclines
4.9: Problem Solving-A General Approach
Chapter 5: Circular Motion; Gravitation
5.1: Kinematics of Uniform Circular Motion
5.2: Dynamics of Uniform Circular Motion
5.6: Newton's Law of Universal Gravitation
Chapter 6: Work and Energy
6.1: Work Done by a Constant Force
6.3: Kinetic Energy and the Work-Energy Principle
6.4: Potential Energy
6.5: Conservative and Nonconservative Forces
6.6: Mechanical Energy and its Conservation
6.7: Problem Solving Using Conservation of Mechanical Energy
6.8: Other Forms of Energy: Energy Transformations and the Law of Conservation of Energy
6.10: Power
Chapter 7: Linear Momentum
7.1: Momentum and Its Relation to Force
7.2: Conservation of Momentum
7.8: Center of Mass (CM)
7.10: Center of Mass and Translational Motion
Chapter 9: Static Equilibrium; Elasticity and Fracture
9.1: The Conditions for Equilibrium
9.2: Solving Statics Problems
9.3: Applications to Muscles and Joints
9.4: Stability and Balance
9.5: Elasticity; Stress and Strain
9.6: Fracture
Thermodynamics
Chapter 13: Temperature and Kinetic Theory
13.1: Atomic Theory of Matter
13.2: Temperature and Thermometers
13.3: Thermal Equilibrium and the Zeroth Law of Thermodynamics
13.4: Thermal Expansion
13.6: The Gas Laws and Absolute Temperature
13.7: The Ideal Gas Law
13.8: Problem Solving with the Ideal Gas Law
Chapter 14: Heat
14.1 Heat as Energy Transfer
14.2 Internal Energy
14.3: Specific Heat
14.4: Calorimetry
14.5: Latent Heat
14.6: Heat Transfer: Conduction
14.7: Heat Transfer: Convection
14.8: Heat Transfer: Radiation
Chapter 15: The Laws of Thermodynamics
15.1: The First Law of Thermodynamics
15.2: Thermodynamic Processes and the First Law
Fluids
Chapter 10: Fluids
10.1: Phases of Matter
10.2: Density and Specific Gravity
10.3: Pressure in Fluids
10.4: Atmospheric Pressure Gauge Pressure
10.5: Pascal's Principle
10.6: Measurement of Pressure; Gauges and the Barometer
10.7: Buoyancy and Archimedes' Principle
Vibrations and Waves
Chapter 11: Vibrations and Waves
11.7: Wave Motion
11.8: Types of Waves: Transverse and Longitudinal
11.9: Energy Transported by Waves
11.10: Intensity Related to Amplitude and Frequency
Chapter 12: Sound
12-1 Characteristics of Sound
12-2 Intensity of Sound: Decibels
12-7 Doppler Effect
Electricity and Magnetism
Chapter 16: Electric Charge and Electric Field
16.1: Static Electricity; Electric Charge and its Conservation
16.2: Electric Charge in the Atom
16.3: Insulators and Conductors
16.4: Induced Charge; the Electroscope
16.5: Coulomb's Law
16.6: Solving Problems Involving Coulomb's Law and Vectors
16.7: The Electric Field
16.8: Field Lines
16.9: Electric Fields and Conductors
Chapter 17: Electric Potential
17.1: Electric Potential Energy and Potential Differences
17.2: Relation Between Electric Potential and Electric Field
17.3: Equipotential Lines
17.4: The Electron Volt, a Unit of Energy
17.5: Electric Potential Due to Point Charges
17.7: Capacitance
17.8: Dielectrics
17.9: Storage of Electric Energy
Chapter 18: Electric Currents
18.1: The Electric Battery
18.2: The Electric Current
18.3: Ohm's Law: Resistance and Resistors
18.4: Resistivity
18.5: Electric Power
Chapter 19: DC Circuits
19.1: EMF and Terminal Voltage
19.2: Resistors in Series and in Parallel
19.3: Kirchhoff's Rules
19.4: EMFs in Series and in Parallel; Charging a Battery
19.5: Circuits Containing Capacitors in Series and in Parallel
19.6: RC Circuits-Resistor and Capacitor in Series
Chapter 20: Magnetism
20.1: Magnets and Magnetic Fields
20.2: Electric Current Produce Magnetic Fields
20.3: Force on an Electric Current in a Magnetic Field: Definition of B
20.4: Force on an Electric Charge Moving in a Magnetic Field
20.5: Magnetic Field Due to a Long Straight Wire
20.8: Ampere's Law
Chapter 21: Electromagnetic Induction and Faraday's Law
21.1: Induced EMF
21.2: Faraday's Law of Induction; Lenz's Law
21.3: EMF Induced in a Moving Conductor
21.4: Changing Magnetic Flux Produces an Electric Field
Chapter 22: Electromagnetic Waves
22.1: Changing Electric Fields Produce Magnetic Fields; Maxwell's Equations
22.2: Production of Electromagnetic Waves
22.3: Light as an Electromagnetic Wave and the Electromagnetic Spectrum
22.5: Energy in EM Waves
Chapter 24: The Wave Nature of Light
24.4: The Visible Spectrum and Dispersion
Chapter 25: Optical Instruments
25-11: X-Rays and X-Ray Diffraction
25-12: X-Ray Imaging and Computed Tomography (CT Scan)
( reference books)
Douglas C. Giancoli “PHYSICS: Principles with Applications” Seventh edition or subsequent,
Pearson Education. Inc
The indicated textbook is just a reference. Students are allowed to adopt the book/books of their
choice. Additional material will be provided by the instructor.
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3
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FIS/07
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30
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-
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Basic compulsory activities
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ITA |
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Medical statistics
(objectives)
The Medical Statistics course aims to introduce students to the logic of statistical thinking and its application in everyday life. The exposition of the topics will be oriented towards concrete problems of analysis and research, starting from schematic examples and then confronting real situations taken from the medical literature.
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Weltert Luca Paolo
( syllabus)
The first part of the course will introduce the logic of statistics and experimental design.
The concepts of probability calculation and combinatorial calculation will be introduced or recalled; although theoretically already in possession of the student, these steps are fundamental and will be used in the continuation of the course. In this phase the main probability distributions will be treated, including the binomial distribution, the Poisson distribution and the standard Normal and Normal distributions, but more than the single mathematical process,we will try making the student aware of the deep motivation of the medical statistics, as a science, and its application in practice, as well as the risks of its incorrect understanding.
In the second part of the course the descriptive statistics and its methodology will be addressed. It will be shown how to recognize the type of data and how to summarize them in appropriate indexes.
The student will learn how to calculate position measurements (mean, median, fashion), variability (variance, standard deviation), coefficient of variation (CV), percentiles and their use. It will also make extensive use of practical examples to define a good descriptive statistic and a defective or deceptive descriptive statistic.
In the final part of the course the general principles of statistical inference will be treated.
Cases of sample distribution, type I and II errors, power of a test and operating curve will be introduced. We will then move on to parametric tests - Student's t-test, ANOVA with 1 and 2 classification criteria, non-parametric tests: - Wilcoxon test, Mann-Whitney test, Kruskal-Wallis test, Friedman test, median test, chi-square test, Fisher exact test. We will also provide the basic concepts of regression and analysis of time dependent variability with mention of Kaplann Meyer functions, log rank and Cox regression.
( reference books)
1) Notes of the lessons
2) Stanton A. Glantz: Statistics for Bio-medical disciplines - ed. McGraw-Hill
3) Sidney Siegel, N. John Castellan Jr.: - Non parametric statistics - ed. McGraw-Hill
4) Resources and links from the Internet with particular reference to the use of the PubMEd portal
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3
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MED/01
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30
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-
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-
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-
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Basic compulsory activities
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ITA |
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Information technology
(objectives)
The course intends to provide students with the basic knowledge to understand the essential role of Information Technology (IT) in our society, and specifically in the context of health-related technical professions.
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Bocciarelli Paolo
( syllabus)
• Introduction to IT systems
• The hardware part of IT systems (CPU, memory, Input/Output)
• The software part of IT systems: system software (operating systems and utility programs), application software (word processing, spreadsheet, database, etc.)
( reference books)
Deborah Morley and Charles S. Parker, Understanding Computers: Today and Tomorrow (16th edition) - Cengage Learning
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2
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INF/01
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20
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-
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Basic compulsory activities
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ITA |
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90323 -
Histology, biology, anatomy and genetics
(objectives)
The Histology module aims to provide student with the skills necessary for the full understanding of the most important tissues of the human organism. The student must be able to acquire a correct terminology and develop skills of interpretation and application that, the graduate in Biomedical Laboratory Techniques, will have to use in the planning and management of work activities.
The Biology module aims at providing the students with the morphological and functional organization of prokaryotic and eukaryotic cells, focusing on both the descriptive aspects and the basic notions of biochemistry and cellular physiology required to understand the functions of the cell as a basic unit of living organisms.
The objective of the course is the learning of the constructive logic of the biological structures at the different levels of organization of living matter, the principles that govern the functioning of the different biological systems, the learning of the experimental method and its applications to the study of biological phenomena.
Students will learn the unitary mechanisms that regulate cellular activities, gene expression and genetic material transmission.
The Anatomy module provides the student with the anatomical knowledge from a basic macroscopic point of view to understand the general organization of the human body.
The teaching objectives are the acquisition of the morphological knowledge and the topographic organization of the single systems, organs and apparatuses in order to acquire the basic notions for the subsequent integrated courses
The aim of the course of Medical Genetics is to provide to students the knowledge on the main notions on inheritance of monogenic, chromosomal and multifactorial diseases.
At the end of the course the student will be able to distinguish the main classes of genetic diseases and to recognize the modes of transmission of hereditary diseases. The student will acquire knowledge of the main methods of analysis useful for the diagnosis of these pathologies.
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Histology
(objectives)
The course aims to provide student with the skills necessary for the full understanding of the most important tissues of the human organism. The student must be able to acquire a correct terminology and develop skills of interpretation and application that, the graduate in Biomedical Laboratory Techniques, will have to use in the planning and management of work activities.
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Massimiani Micol
( syllabus)
Preparation of tissues for histological analysis
Microscopy, preservation of biological structures, stainings.
Epithelial tissues
Classification of epithelia, polarity of epithelial cells, junctions, absorbent epithelia, glandular epithelia.
Connective tissues
Connective tissue proper: extracellular matrix and connective cells. The different types of connective tissue proper. Adipose tissue. Blood and hematopoietic tissues. Supportive connective: cartilage and bone.
Muscle tissue
Skeletal muscle: structure of muscle fibers, contraction mechanism, diversity of muscle fibers. Cardiac muscle: structure of cardiomyocytes and myocardial conduction mechanism. The smooth muscle.
Nervous tissue
The neuron. Glial cells. Myelinated and unmyelinated nerve fibers. General structure of the nerves.
( reference books)
• William Bloom, Don W. Fawcett, “Elementi di istologia”, II edizione a cura di V. Cimini, CIC Edizioni Internazionali.
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2
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BIO/17
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20
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-
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Basic compulsory activities
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ITA |
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Human anatomy
(objectives)
The course provides the student with the anatomical knowledge from a basic macroscopic point of view to understand the general organization of the human body.
The teaching objectives of teaching are the acquisition of the morphological knowledge and the topographic organization of the single systems, organs and apparatuses in order to acquire the basic notions for the subsequent integrated courses
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Izzo Paolo
( syllabus)
- Introduction
- General (General Anatomy).
- Locomotor apparatus (general information on osteology, arthrology, myology).
- Cardiovascular system(morphology and structure of the heart and large vessels).
- Lymphatic circulatory system and lymphoid organs(morphology and structure: general, pulmonary circulation, main lymphatic trunks).
- Respiratory system (morphology and structure: upper airways, lungs, pleurae, mediastinum).
- Digestive system(morphology, structure: pharynx, esophagus, stomach, small and large intestine, liver and biliary tract, pancreas).
- Urinary system(morphology and structure: kidney and urinary tract).
- Male and female genital apparatus (morphology and structure: testis, epididymis, vas deferens, ejaculatory duct, seminal vesicles, prostate, ovary, uterine tube, uterus and vagina).
- Nervous system (brief notes on the sensory and motor pathways, spinal cord, brainstem, cerebellum, diencephalon and telencephalon).
( reference books)
Martini et al. Anatomia Umana, VII edizione - Edises;
Seeley et al. Anatomia, II edizione - Idelson-Gnocchi
Montagnani et al. Anatomia Umana Normale - Idelson-Gnocchi
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2
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BIO/16
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20
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-
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Basic compulsory activities
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ITA |
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General and cellular biology
(objectives)
The Biology module aims at providing the students with the morphological and functional organization of prokaryotic and eukaryotic cells, focusing on both the descriptive aspects and the basic notions of biochemistry and cellular physiology required to understand the functions of the cell as a basic unit of living organisms.
The objective of the course is the learning of the constructive logic of the biological structures at the different levels of organization of living matter, the principles that govern the functioning of the different biological systems, the learning of the experimental method and its applications to the study of biological phenomena.
Students will learn the unitary mechanisms that regulate cellular activities, gene expression and genetic material transmission.
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Nardacci Roberta
( syllabus)
Characteristic of living cells: Cellular theory. Classification principles of living organisms.
Prokaryotic and eukaryotic cell models: classification and major structural differences.
Cell Chemistry: Macromolecules: structure, shape and function
Plasma membrane: properties and functions.
Internal organization of the cell: Cellular compartments. Cytoplasm and cytoplasmic organelles, ribosomes, smooth and rought endoplasmic reticulum, Golgi apparatus, lysosomes, peroxisomes.
The cytoskeleton. Microtubules, intermediate filaments and microfilaments. Cilia and flagella. Centrioles and centrosomes.
Energy conversion: Glycolysis, fermentation, cellular respiration, photosynthesis. (outline). Mitochondria and Chloroplasts, structure and function.
Molecular basis of hereditary information: DNA replication. DNA repair and its correlation with human diseases.
RNA, structure and function: Main types of cellular RNAs and differences with respect to DNA in terms of molecular size, stability and biological functions. Transcription and RNA maturation.
Genetic Code and its properties. Protein synthesis: How cells read the genome. Main post-translational modifications of the polypeptide chains.
Post-synthetic fate of proteins, endomembranes and membrane traffic: Endocytosis and exocytosis.
Cell Cycle, Mitosis and Meiosis
( reference books)
• Sadava, Hillis, Heller, Hacker. Elementi di Biologia e Genetica Zanichelli editore, V ed.
• Raven,Johnson, Mason, Losos, Singer. Elementi di Biologia e Genetica Piccin editore II ed
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2
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BIO/13
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20
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-
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-
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Basic compulsory activities
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ITA |
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Medical genetics
(objectives)
The aim of the course of Medical Genetics is to provide to students the knowledge on the main notions on inheritance of monogenic, chromosomal and multifactorial diseases.
At the end of the course the student will be able to distinguish the main classes of genetic diseases and to recognize the modes of transmission of hereditary diseases. The student will acquire knowledge of the main methods of analysis useful for the diagnosis of these pathologies.
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Ciccacci Cinzia
( syllabus)
Basic Genetics: Definitions of Key Terms: gene, locus, allele, genotype, phenotype, haplotype, homozygous, heterozygous, haploid, diploid, dominance, recessivity, codominance, mutation, polymorphism.
Principles of Genetic Transmission: Mendel's Genetic Hypothesis, The Monohybrid and dihybrid Crosses, Segregation in Human Pedigrees, Blood groups Genetics
Monogenic Inheritance Models: Autosomal inheritance, Autosomal recessive inheritance, X-linked inheritance
Genetic Risk calculation and pedigrees. Hardy-Weinberg equilibrium
Chromosomes: Structure and Analysis, Chromosomes Pathologies
Genomic Imprinting and X-chromosome inactivation
Mitochondrial inheritance: mitochondrial DNA, pattern of inheritance
Multifactorial inheritance: polimorphisms, susceptibility genes, gene-environment interaction, association studies
Pharmacogenomics and Personalised Medicine
Old and new technologies in Genetics. Examples with clinical cases
Genetic tests and Counselling. Outlines
( reference books)
Lectures in pdf format will be provided to students.
Recommended books:
“Genetica in Medicina”, by Nussbaum, McInnes, Willard. Edises
“Genetica Medica Essenziale” by Dallapiccola, Novelli. Cic editore
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2
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MED/03
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20
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-
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Basic compulsory activities
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ITA |
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90324 -
Biochemistry, physiology and microbiology
(objectives)
The aim of the integrated teaching of BIOCHEMISTRY, PHYSIOLOGY AND MICROBIOLOGY is to provide students with the fundamental knowledge relating to the structure of the macromolecules necessary for the functioning and regulation of living organisms and their transformation processes. Put the student in a position to understand the basics of cellular metabolism and the variations induced by exercise. The module also intends to provide the student with the fundamental knowledge relating to the basic concepts of chemistry, the structure of macromolecules underlying the metabolic processes necessary for the functioning and regulation of living organisms: carbohydrates, lipids, nucleic acids. To enable the student to understand the basics of cellular metabolism. The cellular mechanisms and integrated functions of the main organs and systems aimed at maintaining body homeostasis in the context of changes in the environment will also be analyzed. Knowledge of the structure of the various microorganisms, of the microbial pathogenicity, of the interactions between microorganism and host, of the causes and mechanisms of onset of the main diseases with microbial etiology are essential objectives. The course aims to provide the student with some essential methods used in biochemical practice and the theoretical principles on which these methodologies and their field of application are based.
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Physiology
(objectives)
The aim of the teaching is, starting from the knowledge of the basic concepts and the normal quantitative parameters of the bodily functions and their variations in the different conditions of dynamic engagement, to develop in the student the ability to understand the principles of the functioning of the human body. The cellular mechanisms and the integrated functions of the main organs and apparatuses aimed at the maintenance of body homeostasis will also be analyzed in the context of environmental modifications.
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Pallone Gabriele
( syllabus)
Physiology of the cell membrane:
-Transport of ions and molecules through the cell membrane
- Membrane potential and Action Potential
Muscle Physiology:
-Excitation and contraction of skeletal muscle tissue.
- Neuromuscular transmission and excitation-contraction coupling.
- Motor unit
Physiology of the Nervous System:
-The sensory system: decoding and processing of sensory information.
-The motor system: general characteristics of the motor system: involuntary, voluntary and automatic movements; spinal reflexes; the brain-encephalic control of the movement: posture and balance. Cortical control of voluntary movements. The cerebellum: general features, functions of the cerebellum. The basal ganglia: functional role.
-The autonomic nervous system.
- Supplementary functions of the nervous system.
Cardiovascular physiology:
- Myocardial physiology: functional myocardial anatomy, myocardial action potentials, contraction of the heart muscle.
- Cardiac cycle
- Nervous control of cardiac activity.
- General principles of hemodynamics.
-Adjustment of circulation, blood pressure and blood flow.
- Cardiac output: principles of regulation of cardiac output.
- Cardiac tones.
The Respiratory System:
- Pulmonary ventilation: respiratory mechanics, volumes and lung capacity. Respiratory tract
- Gaseous exchanges: diffusion of oxygen and carbon dioxide through the respiratory membrane.
-Transportation of oxygen and carbon dioxide in blood and body fluids ..
-Regulation of breathing: general principles.
-Regulation of acid-base balance: general principles.
Body fluids and renal function:
- Functional anatomy of the kidney, function of the nephron. Glomerular filtration: general principles.
- Elaboration of glomerular filtrate: resorption and tubular secretion,
-Control of osmolarity and sodium concentration of extracellular fluid: general principles.
-Renal regulation of blood volume: general principles
The endocrine system:
General principles of endocrinology: nature of a hormone; general picture of the endocrine glands and their hormones. Principles of general functioning of hormones.
( reference books)
-“Berne & Levy Physiology”, Sixth Updated Edition
-“Sherwood” ninth edition
-“Guyton-Hall"
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2
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BIO/09
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20
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-
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-
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-
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Basic compulsory activities
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ITA |
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Biochemistry
(objectives)
To provide the student with the fundamental knowledge related to the structure of the macromolecules envolved in metabolic pathways necessary for the functioning and regulation of living organisms. Make the student to understand the basics of cellular metabolism.
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Nicolai Eleonora
( syllabus)
CHEMICAL ELEMENTS :
Atoms and molecules
Chemical reactions
Ionic equilibrium in solution
Water
Elements of organic chemistry
BIOCHEMISTRY :
Carbohydrates
Lipids
Nucleic acids
Proteins
Digestion
INTRODUCTION TO METASBOLISM :
Generality
Catabolism
Anabolism
( reference books)
Appunti di biochimica. Per le lauree triennali
M.V.Catani, V.Gasperi, A.Di Venere , I.Savini , P.Guerrieri , L.Avigliano
Piccin editore
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Di Venere Almerinda
( syllabus)
Amino acids: general structure and classification. Proteins: structure and function. Structural levels. Protein folding. Fibrous proteins: structure of alpha-keratin, collagen and fibroin of silk. Globular proteins: structure and function of myoglobin and hemoglobin; the EME group; saturation curve; regulation of the affinity of hemoglobin for oxygen. Enzymes: general characteristics; activation energy and reaction rate; general concepts on enzyme kinetics. Regulatory mechanisms: competitive and non-competitive inhibitors; allosteric enzymes and enzymes regulated by covalent modifications. Catalytic strategies. Serine-protease catalysis. The blood coagulation cascade as an example to clarify specificity determinants (exositional concept), the role of cofactors and the formation of macromolecular complexes. Bioenergetics and Metabolism Principles of bioenergetics. The transfer of phosphate groups. Structure and function of the ATP. The electron transporters (NADH, NADPH and FADH2). Coenzyme A. General concepts on carbohydrates. Use of glucose. Glycolysis: phases and regulation. Gluconeogenesis. Allosteric and hormonal regulation. General concepts on the way of pentose phosphate. Glycogen. Degradation and synthesis, and coordinated regulation. Pyruvate fate in aerobic and anaerobic conditions. Synthesis of Acetyl-CoA: pyruvate dehydrogenase. Lactic fermentation (Cori cycle) and alcoholic. Citric acid cycle: Functions, energy balance and regulation. Oxidative phosphorylation: electron transporters. Electron flow and ATP synthesis.
( reference books)
Appunti di biochimica. Per le lauree triennali
M.V.Catani, V.Gasperi, A.Di Venere , I.Savini , P.Guerrieri , L.Avigliano
Piccin editore
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4
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BIO/10
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40
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-
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-
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-
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Basic compulsory activities
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ITA |
|
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Applied biochemistry
(objectives)
The teaching aims to provide to the students the essentials metodhologies needed to execute the diagnostic methods on biological materials and the theoretical concepts that underlie.
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Montagna Costanza
( syllabus)
Solutions: Concentration, molarity, molality, molar ratio, dilution, stoichiometry.
Immunochemistry: General aspects of the immune system, production of antibodies, immunochemical assays, Elisa, immunohistochemistry.
Electrophoretic techniques: General principles, supports used in electrophoresis, polyacrylamide gel electrophoresis (PAGE), SDS-PAGE, Western blot.
Molecular biology techniques: General aspects of the genetic, mutations and clinical significance, PCR, sequencing, principle of genomic and NGS sequencing.
( reference books)
- ”Biochemistery”, Terry A. Brown; Scion Publishing.
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1
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BIO/12
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10
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-
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-
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-
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Basic compulsory activities
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ITA |
|
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Microbiology
(objectives)
Essential learning objectives of the course will be the knowledge of the structure of different microorganisms, of the microbial pathogenicity, of the interactions between micro-organism and host, of the causes and mechanisms of onset of the main microbial aetiology diseases. Furthermore, knowledge on bacterial, viral, mycotic or protozoal aetiology infections will be indispensable in order to understand all methodologies for the laboratory diagnosis of microbial infections during professional activity. These objectives will be achieved through frontal lectures, seminars and interactive teaching activities, designed to facilitate learning and improve the ability to address and solve the main questions of Clinical Microbiology.
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Armenia Daniele
( syllabus)
COURSE SYLLABUS
Basic principles of microbiology
Morphology and structure of the bacterial cell
Structure of bacterial spores and sporulation process
Gram coloring and coloring for acid resistance
Metabolism, growth and bacterial replication
Sterilization, disinfection, asepsis
Structure, replication and mechanisms of fungal pathogenicity
Morphology of viral particles
Cellular Tropism and Host Spectrum
Viral Enzymes
Virus classification
Phases of viral replication
Basic concepts of immune response
Natural immune response of host
Humoral acquired immune response
Cell-mediated acquired immune response
Immune responses against infectious agents
Interferon mechanisms of action
Vaccines and passive immunoprophylaxis
Mechanisms of bacterial pathogenesis
Demonstration of causal nature between pathogen and disease: Koch postulates
Normal microbial flora of our organism
Host-microorganism" interactions: Commensalism - Mutualism - Parasitism
Factors influencing the "host - microorganism" balance
Modes of transmission of the infection
Steps in the infectious process
Bacterial virulence factors
Mechanisms of viral pathogenesis and interaction with the host
Transmission mode
Steps in the infectious process
Localized and disseminated infection
State of persistence and latency
Viral Oncogenesis
Virus-induced cytopathic effect
Alteration of expression of genes and/or cellular proteins
( reference books)
Title: The basics of Microbiology
Authors: Richard A. Harvey, Pamela C. Champe Bruce D. Fisher
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2
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MED/07
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20
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-
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-
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-
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Core compulsory activities
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ITA |
|
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Technical sciences of laboratory medicine
(objectives)
The main knowledge on the correct organization of a laboratory is essential, the knowledge and correct management of the instruments. Very important goal is knowledge of the main tubes with and without anticoagulants used in a clinical biochemistry laboratory.
These objectives will be achieved through lectures, interactive teaching, designed to facilitate learning and improve the ability to address and resolve the main questions of the clinical biochemistry laboratory
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Casalino Paolo
( syllabus)
-Organization of a laboratory
-Knowledge of the main laboratory instruments
-Types of tubes (with and without anticoagulants) used in analytical investigations
-Blood count and basic concepts on blood tests
-The various stages of an analytic process
( reference books)
The student will be provided with educational material, such as notes and presentations
|
1
|
MED/46
|
10
|
-
|
-
|
-
|
Core compulsory activities
|
ITA |
