| Clinical biochemistry and pharmaceuticals toxicology
(objectives)
The course aims to acquire the fundamental principles of pharmacokinetics, pharmacodynamics, toxicology, and pharmaceutical galenics, which form the basis for conducting biochemical and pharmacogenetic tests in diagnostic and research laboratories, as well as the theoretical foundations for the preparation of galenic drugs. Students should be familiar with the scientific rigor and methodological approach underlying the development of new drugs. They should also learn the fundamental aspects related to the therapeutic use of the most frequently used drug classes. These objectives will be achieved through lectures, seminars, and interactive educational activities designed to facilitate learning and enhance the ability to address and resolve key issues in the pharmaceutical, toxicological, and pharmaceutical galenic industries. The educational objectives of the module of Special Clinical Biochemistry are aimed at acquiring knowledge of the main methodologies used in clinical biochemistry; understanding the significance of alterations in biochemical-clinical relevant profiles.
|
|
Code
|
90334 |
|
Language
|
ITA |
|
Type of certificate
|
Profit certificate
|
| Module: Special clinical biochemistry
(objectives)
The integrated teaching of Clinical Biochemistry and Pharmacotoxicology aims to acquire the
fundamental principles of pharmacokinetics, pharmacodynamics, toxicology and pharmaceutical
galenics, at the basis of the execution of biochemical and pharmacogenetic tests, carried out in
diagnostic and research laboratories as well as the theoretical bases for the preparation of galenic
drugs. Student will be taught the scientific precision and methodological approach underlying the
development of new drugs and the fundamental aspects connected with the therapeutic use of the
most frequently used drug classes. The activity of the clinical biochemistry laboratory in the
diagnostic process will be presented, from the preparation of samples to the understanding of the
meaning of the alterations of the most relevant biochemical-clinical profiles, and some
methodologies used in biochemical diagnostics and for therapeutic monitoring of drugs. At the end
of the Integrated Teaching, the student will have acquired the ability to deal with the main
technologies of the pharmaceutical, toxicological and galenic pharmaceutical industry, to use the
procedures of the clinical laboratory, to correctly analyze and interpret the diagnostic data and to
cooperate in clinical reasoning.
|
|
Language
|
ITA |
|
Type of certificate
|
Profit certificate
|
|
Credits
|
2
|
|
Scientific Disciplinary Sector Code
|
BIO/12
|
|
Contact Hours
|
20
|
|
Type of Activity
|
Core compulsory activities
|
|
Teacher
|
Pieroni Luisa
(syllabus)
● From the collection of the biological sample to the report: Pre-preanalytical phase, preanalytical
phase, analytical phase, post-analytical phase, interpretation of the results.
● Analytical groupings: Blood, urine, feces, liquor, hair and saliva.
● Biochemical-clinical profiles of relevance: Glucose profile, protein profile, lipid profile, vitamin
profile.
● Analytical techniques for Pharmacodynamic analysis: Mass spectrometry in the clinical
laboratory. Potential and applications.
(reference books)
● Biochimica clinica essenziale, dal laboratorio ai quadri di patologia clinica. Elisabetta Albi
Tommaso Beccari Samuela Cataldi. Zanichelli 2019.
● Teaching material provided by the teacher during the lessons
|
|
Dates of beginning and end of teaching activities
|
From to |
|
Delivery mode
|
Traditional
|
|
Attendance
|
not mandatory
|
|
Evaluation methods
|
Written test
Oral exam
|
|
|
| Module: Pharmaceutical toxicology and galenic pharmacology
(objectives)
The integrated teaching of Clinical Biochemistry and Pharmacotoxicology aims to acquire the
fundamental principles of pharmacokinetics, pharmacodynamics, toxicology and pharmaceutical
galenics, at the basis of the execution of biochemical and pharmacogenetic tests, carried out in
diagnostic and research laboratories as well as the theoretical bases for the preparation of galenic
drugs. Student will be taught the scientific precision and methodological approach underlying the
development of new drugs and the fundamental aspects connected with the therapeutic use of the
most frequently used drug classes. The activity of the clinical biochemistry laboratory in the
diagnostic process will be presented, from the preparation of samples to the understanding of the
meaning of the alterations of the most relevant biochemical-clinical profiles, and some
methodologies used in biochemical diagnostics and for therapeutic monitoring of drugs. At the end
of the Integrated Teaching, the student will have acquired the ability to deal with the main
technologies of the pharmaceutical, toxicological and galenic pharmaceutical industry, to use the
procedures of the clinical laboratory, to correctly analyze and interpret the diagnostic data and to
cooperate in clinical reasoning.
|
|
Language
|
ITA |
|
Type of certificate
|
Profit certificate
|
|
Credits
|
3
|
|
Scientific Disciplinary Sector Code
|
BIO/14
|
|
Contact Hours
|
30
|
|
Type of Activity
|
Basic compulsory activities
|
|
Teacher
|
Apolloni Savina
(syllabus)
● Principles of general pharmacology: definition of drug; classification and nomenclature of drugs;
desired and undesired effects of drugs.
● General principles of pharmacokinetics: routes of administration, absorption, distribution,
metabolism, elimination of drugs.
● Pharmacogenomics: individual variability and response to drugs, variations in target proteins,
variations in enzymes responsible for drug metabolism.
● Principles of toxicology; toxicokinetics; mechanisms of intoxication and detoxification; main
sources of toxicity; toxic effects of drugs
● General principles of pharmacodynamics: receptors and mechanisms of action of drugs.
● Development of new drugs: general principles of pharmacological sensitivity tests conducted in
vitro; preclinical studies, experimental models of pathologies and clinical trials.
● Pharmacology of the autonomic nervous system (parasympathomimetics and cholinergic
antagonists; sympathomimetics and adrenergic antagonists).
● Pharmacology of the central nervous system (anxiolytics, antipsychotics, antidepressants, drugs
for neurodegenerative diseases)
● Special Pharmacology; general characteristics of the following classes of drugs: anti-
inflammatories, antihistamines, opioid analgesics, immunosuppressants, antimicrobial agents, and
antitumor agents, notes on gastrointestinal, pulmonary, and cardiovascular pharmacology.
● Principles of pharmaceutical galenics, techniques for galenic and pharmaceutical preparations,
auxiliary substances in galenic preparations: solvents, excipients, preservatives. Techniques
applied in UFA laboratories and in CAR-T therapies.
(reference books)
● Di Giulio et al. Farmacologia generale e speciale per le lauree sanitarie. Piccin, seconda
edizione
● Amico Roxas et al. Compendio di farmacologia generale e speciale, seconda edizione EDRA
2021
● Clementi F., Fumagalli G. FARMACOLOGIA GENERALE E MOLECOLARE 5a edizione EDRA
2018.
● C. Colombo, F. Alhaique, C. Caramella, B. Conti, A. Gazzaniga, E. Vidale. Principi di
Tecnologia Farmaceutica. Zanichelli 2015.
● Teaching material provided by the teacher during the lessons
|
|
Dates of beginning and end of teaching activities
|
From to |
|
Delivery mode
|
Traditional
|
|
Attendance
|
not mandatory
|
|
Evaluation methods
|
Written test
Oral exam
|
|
|
|
