| I.C. Biological and biochemical foundations of living systems
(objectives)
The teaching of Biological and Biochemical Bases of Life, through the integration of biological and medical disciplines, is aimed at making the student acquire knowledge relating to the physiological, morphological, structural, and genetic characteristics of living organisms, and the causes of occurrence of events pathological even of microbial origin. The student will also be introduced to the logic and tools underlying the execution of diagnostic tests of clinical biochemistry and molecular biology and radiology. At the end of integrated teaching, the student, thanks to the basic knowledge acquired, will be able to understand physiological and pathological mechanisms and to interpret and evaluate the results of diagnostic and radiological tests in clinical practice.
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Code
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90171 |
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Language
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ENG |
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Type of certificate
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Profit certificate
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| Module: Applied biology
(objectives)
The teaching of Biological and Biochemical Bases of Life, through the integration of biological and medical disciplines, is aimed at making the student acquire knowledge relating to the physiological, morphological, structural, and genetic characteristics of living organisms, and the causes of occurrence of events pathological even of microbial origin. The student will also be introduced to the logic and tools underlying the execution of diagnostic tests of clinical biochemistry and molecular biology and radiology. At the end of integrated teaching, the student, thanks to the basic knowledge acquired, will be able to understand physiological and pathological mechanisms and to interpret and evaluate the results of diagnostic and radiological tests in clinical practice. In details: The teaching of Biological and Biochemical Bases of Life, through the integration of biological and medical disciplines, is aimed at making the student acquire knowledge relating to the physiological, morphological, structural, and genetic characteristics of living organisms, and the causes of occurrence of events pathological even of microbial origin. The student will also be introduced to the logic and tools underlying the execution of diagnostic tests of clinical biochemistry and molecular biology and radiology. At the end of integrated teaching, the student, thanks to the basic knowledge acquired, will be able to understand physiological and pathological mechanisms and to interpret and evaluate the results of diagnostic and radiological tests in clinical practice.
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Language
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ENG |
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Type of certificate
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Profit certificate
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Credits
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2
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Scientific Disciplinary Sector Code
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BIO/13
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Contact Hours
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20
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Type of Activity
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Basic compulsory activities
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Teacher
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Bruni Emanuele
(syllabus)
- Origin of life. Eukaryotic cell and prokaryotic cell. Bacteria and archaeobacteria. Virus. - Structure and function of biological molecules. Carbohydrates, lipids, proteins, nucleic acids. Water and pH. - How to study the cell (optical and electronic microscopes; biochemical methods). - Cellular compartments and organelles (the plasma membrane, the nucleus, the cytoskeleton, the endoplasmic reticulum, the ribosomes, the Golgi complex, the mitochondria, the chloroplasts, the peroxisomes, the lysosomes and the vacuoles). - Movement of molecules. Passive transport, active transport, endocytosis (phagocytosis and pinocytosis), exocytosis. - Nucleic acids. DNA and RNA. Transcription and translation. Regulation of gene expression. - Cell cycle. Types of cell division in prokaryotes and eukaryotes (mitosis and meiosis). - Protein biosynthesis. - Sexual reproduction and its evolutionary meaning. - Tissues, stem cells and cancer. Genes that are critical for cancer development: proto-oncogenes and tumours suppressor genes.
(reference books)
1. Bruce Alberts, Karen Hopkin, Alexander D. Johnson, David Morgan, Martin Raff, Keith Roberts, Peter Walter. “Essential Cell Biology (Fifth Edition)”. Casa editrice: W. W. Norton & Company. 2019.
2. Peter H. Raven, George Johnson, Kenneth A. Mason, Jonathan B. Losos, Tod Duncan. “Biology”. Casa editrice: McGraw-Hill Education, 2019.
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Dates of beginning and end of teaching activities
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From to |
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Delivery mode
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Traditional
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Attendance
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Mandatory
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Evaluation methods
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Written test
Oral exam
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| Module: Radiobiology
(objectives)
The teaching of Biological and Biochemical Bases of Life, through the integration of biological and medical disciplines, is aimed at making the student acquire knowledge relating to the physiological, morphological, structural, and genetic characteristics of living organisms, and the causes of occurrence of events pathological even of microbial origin. The student will also be introduced to the logic and tools underlying the execution of diagnostic tests of clinical biochemistry and molecular biology and radiology. At the end of integrated teaching, the student, thanks to the basic knowledge acquired, will be able to understand physiological and pathological mechanisms and to interpret and evaluate the results of diagnostic and radiological tests in clinical practice. In details: Radiobiology teaching aims to introduce the student to the radiological discipline and to provide him with the basic knowledge of radiation physics and radiobiology.
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Language
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ENG |
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Type of certificate
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Profit certificate
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Credits
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1
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Scientific Disciplinary Sector Code
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MED/36
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Contact Hours
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10
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Type of Activity
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Core compulsory activities
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Teacher
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Ciabattoni Antonella
(syllabus)
• Definition and physical principles of Radiation and distinction between types of radiation (Non-Ionizing Radiation and Ionizing Radiation). • Main sources of natural and artificial radiation. Radioactivity and radioactive decay • Effects of radiation on DNA and mechanisms of repair of radio-induced damage; effects of radiation exposure to tissues, organs and the whole organism • Use of radiation in diagnostic imaging and radiotherapy
(reference books)
1. Radiation Biology: A Handbook For Teachers And Students, IAEA Training Course Series 42, 2010 2. Radiobiology for the radiologist / Eric J. Hall, Amato J. Giaccia.—7th ed.
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Dates of beginning and end of teaching activities
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From to |
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Delivery mode
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Traditional
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Attendance
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Mandatory
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Evaluation methods
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Written test
Oral exam
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| Module: Biochemistry
(objectives)
The teaching of Biological and Biochemical Bases of Life, through the integration of biological and medical disciplines, is aimed at making the student acquire knowledge relating to the physiological, morphological, structural, and genetic characteristics of living organisms, and the causes of occurrence of events pathological even of microbial origin. The student will also be introduced to the logic and tools underlying the execution of diagnostic tests of clinical biochemistry and molecular biology and radiology. At the end of integrated teaching, the student, thanks to the basic knowledge acquired, will be able to understand physiological and pathological mechanisms and to interpret and evaluate the results of diagnostic and radiological tests in clinical practice. In details: The teaching of Biochemistry will allow you to acquire knowledge of the main biological macromolecules, of the functioning mechanism of enzymes, a general knowledge of the main metabolic pathways and, in more detail, of the main pathway of glucose catabolism.
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Language
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ENG |
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Type of certificate
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Profit certificate
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Credits
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2
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Scientific Disciplinary Sector Code
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BIO/10
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Contact Hours
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20
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Type of Activity
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Basic compulsory activities
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Teacher
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Nicolai Eleonora
(syllabus)
• Structure / function of biological molecules: Structure of proteins: amino acids; peptide bond; primary structure; tertiary and quaternary secondary. Protein functions. Myoglobin and haemoglobin. Enzymes: characteristics and functioning; enzymatic inhibition mechanisms. • Glucose catabolism: the anaerobic catabolic pathway, glycolysis and fermentations. • The aerobic catabolic pathway: the Krebs cycle and oxidative phosphorylation. The regulation: hormones and vitamins • Fatty acid catabolism: Beta oxidation. Ketogenesis
(reference books)
1. ”Biochemistry”, D. R. Ferrier Wolters Kluwer; 2. “Lehningher principles of biochemistry”, D. L. Nelson, M.M. Cox (2017) W.H. Freeman & Co.
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Dates of beginning and end of teaching activities
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From to |
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Delivery mode
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Traditional
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Attendance
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Mandatory
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Evaluation methods
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Written test
Oral exam
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| Module: Clinical biochemistry and molecular biology
(objectives)
The teaching of Biological and Biochemical Bases of Life, through the integration of biological and medical disciplines, is aimed at making the student acquire knowledge relating to the physiological, morphological, structural, and genetic characteristics of living organisms, and the causes of occurrence of events pathological even of microbial origin. The student will also be introduced to the logic and tools underlying the execution of diagnostic tests of clinical biochemistry and molecular biology and radiology. At the end of integrated teaching, the student, thanks to the basic knowledge acquired, will be able to understand physiological and pathological mechanisms and to interpret and evaluate the results of diagnostic and radiological tests in clinical practice. In details: The teaching of Clinical Biochemistry and Clinical Molecular Biology aims to provide students with the theoretical-practical knowledge of the basic principles of Biochemistry and Molecular Biology underlying the execution and evaluation of laboratory diagnostic tests.
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Language
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ENG |
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Type of certificate
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Profit certificate
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Credits
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2
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Scientific Disciplinary Sector Code
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BIO/12
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Contact Hours
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20
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Type of Activity
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Basic compulsory activities
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Teacher
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Pieroni Luisa
(syllabus)
- Definition, limits and aims of Clinical Biochemistry and Clinical Molecular Biology as disciplines of Laboratory Medicine. - General organization of the Clinical Diagnostic Laboratory: from the request for analysis to the report. - Reference ranges, critical values - Sources of variability in the pre-analytical and analytical phase, intra and inter-individual biological variability, concepts of diagnostic sensitivity and specificity and their applications. Internal and external quality control - Balance of body fluids and electrolytes. Acid-base balance. Conditions associated with abnormal electrolyte composition or acid-base balance - Plasma proteins and enzymes as biomarkers of tissue and organ damage. Evaluation of plasma / serum enzymes and metabolites for diagnostic purposes. - Introduction to Clinical Molecular Biology and Molecular Biomarkers - Methods of preparation and analysis of proteins and nucleic acids in clinical diagnostics (E.g. immuno-detections and immunoassays of proteins, protein and nucleic acid electrophoresis, PCR, gene sequencing, arrays, LC-MS, etc) - Molecular diagnostic tests (genetic and oncological diseases)
(reference books)
1. Michael J. Murphy & Rajeev Srivastava & Kevin Deans “Clinical Biochemistry”, Sixth Edition , Elsevier
2. Michael M. Cox, Jennifer Doudna, Michael O'Donnell. “Molecular Biology: Principles and Practice”; W H Freeman & Co; 2
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Dates of beginning and end of teaching activities
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From to |
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Delivery mode
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Traditional
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Attendance
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Mandatory
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Evaluation methods
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Written test
Oral exam
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| Module: Genetics
(objectives)
The teaching of Biological and Biochemical Bases of Life, through the integration of biological and medical disciplines, is aimed at making the student acquire knowledge relating to the physiological, morphological, structural, and genetic characteristics of living organisms, and the causes of occurrence of events pathological even of microbial origin. The student will also be introduced to the logic and tools underlying the execution of diagnostic tests of clinical biochemistry and molecular biology and radiology. At the end of integrated teaching, the student, thanks to the basic knowledge acquired, will be able to understand physiological and pathological mechanisms and to interpret and evaluate the results of diagnostic and radiological tests in clinical practice. In details: The aim of the Medical Genetics course is to provide students with the knowledge of the inheritance of monogenic, chromosomal, and multifactorial diseases. At the end of the course, the student will be able to distinguish the main classes of genetic diseases and to recognize their transmission.
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Language
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ENG |
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Type of certificate
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Profit certificate
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Credits
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1
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Scientific Disciplinary Sector Code
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MED/03
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Contact Hours
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10
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Type of Activity
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Basic compulsory activities
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Teacher
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Cascella Raffaella
(syllabus)
- Introduction of genetics and terminology: haploid, diploid, gene, locus, allele, genotype, phenotype, haplotype, homozygous, heterozygous, dominance, recessive allele, codominance. - Genetic Variants (mutations/polymorphisms) and inter-individual variability. - Mendel's laws. Transmission patterns of Mendelian (or monogenic) traits: autosomal recessive and dominant inheritance, inheritance linked to recessive and dominant sex, Y-linked. Mitochondrial inheritance. - Risk calculations related to the above models and analysis of family trees. - The genetics of the main blood groups (AB0, Rh) and fetal maternal incompatibility. - Concepts of penetrance, expressiveness, anticipation, consanguinity, genetic heterogeneity - Structure and characteristics of human chromosomes. Chromosome abnormalities: morphological and numerical alteration. Chromosome abnormalities and clinical significance. - Multifactorial traits and Personalized Medicine. - Genetic counselling, genetic tests and their clinical applications.
(reference books)
“Medical Genetics”, autori: Lynn Jorde John Carey Michael Bamshad. Edizioni Elsevier
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Dates of beginning and end of teaching activities
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From to |
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Delivery mode
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Traditional
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Attendance
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Mandatory
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Evaluation methods
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Written test
Oral exam
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| Module: Microbiology
(objectives)
The teaching of Biological and Biochemical Bases of Life, through the integration of biological and medical disciplines, is aimed at making the student acquire knowledge relating to the physiological, morphological, structural, and genetic characteristics of living organisms, and the causes of occurrence of events pathological even of microbial origin. The student will also be introduced to the logic and tools underlying the execution of diagnostic tests of clinical biochemistry and molecular biology and radiology. At the end of integrated teaching, the student, thanks to the basic knowledge acquired, will be able to understand physiological and pathological mechanisms and to interpret and evaluate the results of diagnostic and radiological tests in clinical practice. In details: Knowledge of the structure of the various microorganisms, of the microbial pathogenicity, of the causes and mechanisms of onset of the main diseases with microbial ethology are essential objectives of teaching Microbiology.
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Language
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ENG |
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Type of certificate
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Profit certificate
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Credits
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1
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Scientific Disciplinary Sector Code
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MED/07
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Contact Hours
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10
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Type of Activity
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Basic compulsory activities
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Teacher
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Bouba Yagai
(syllabus)
- Basic principles of microbiology: morphology and structure of the bacterial cell. Bacterial spore structure and sporulation process. Gram stain and stain for acid resistance. Metabolism, growth and bacterial replication. Sterilization, disinfection, asepsis. Morphology of viral particles. Cell tropism and host spectrum. Viral enzymes. Virus classification. Stages of viral replication - Mechanisms of bacterial pathogenesis: Demonstration of the causal nature between pathogen and disease: Koch postulates. Normal microbial flora of our organism. Host-microorganism interactions: Commensalism-Mutualism - Parasitism. Factors that influence the "host-microorganism" balance. Method of transmission of the infection. Stages of the infectious process. Bacterial virulence factors. - Mechanisms of viral pathogenesis and interaction with the host: Method of transmission. Stages of the infectious process. Localized and disseminated infection. Persistence and latency status. Viral oncogenesis. Cytopathic effect induced by viruses. Alteration of expression of genes and / or cellular proteins
(reference books)
The basics of Microbiology. Authors: Richard A. Harvey, Pamela C. Champe Bruce D. Fisher
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Dates of beginning and end of teaching activities
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From to |
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Delivery mode
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Traditional
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Attendance
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Mandatory
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Evaluation methods
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Written test
Oral exam
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