I.C. Biological and biochemical foundations of living systems
(objectives)
The main objective of the course is to acquire knowledge relating to the physiological and morphological characteristics of cells, as functional units of living organisms. The key to any biological problem can, in fact, be sought at the cellular level. Another important goal is the use of the experimental method as a means of understanding the biological mechanisms that regulate life and a tool for the study of pathological processes. The course aims to introduce the student to the radiological discipline and to provide him with the basic knowledge of radiation physics and radiobiology. Knowledge of the main biological macromolecules. Knowledge of the functioning mechanism of enzymes. General knowledge of the main metabolic pathways and, in more detail, of the main pathway of glucose catabolism. The purpose of the Medical Genetics course is to provide students with the main knowledge on the inheritance of monogenic, chromosomal and multifactorial diseases. At the end of the course the student will be able to distinguish the main classes of genetic diseases and to recognize their transmission methods. Knowledge of the structure of the various microorganisms, of the microbial pathogenicity, of the causes and mechanisms of onset of the main diseases with microbial ethology are essential objectives.
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Code
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90171 |
Language
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ENG |
Type of certificate
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Profit certificate
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Module: Applied biology
(objectives)
The main objective of the Applied Biology teaching is to acquire knowledge relating to the physiological and morphological characteristics of cells, as functional units of living organisms. The key to any biological problem can, in fact, be sought at the cellular level. Another important goal is the use of the experimental method as a means of understanding the biological mechanisms that regulate life and a tool for the study of pathological processes.
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Language
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ENG |
Type of certificate
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Profit certificate
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Credits
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2
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Scientific Disciplinary Sector Code
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BIO/13
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Contact Hours
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20
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Type of Activity
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Basic compulsory activities
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Teacher
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Nardacci Roberta
(syllabus)
•Origin of life. Eukaryotic cell and prokaryotic cell. Bacteria and archaeobacteria. Virus. Structure and function of biological molecules. Carbohydrates, lipids, proteins, nucleic acids. Water and pH. How to study the cell (optical and electronic microscopes; biochemical methods). Cellular compartments and organelles (the plasma membrane, the nucleus, the cytoskeleton, the endoplasmic reticulum, the ribosomes, the Golgi complex, the mitochondria, the chloroplasts, the peroxisomes, the lysosomes and the vacuoles). Movement of molecules. Passive transport, active transport, endocytosis (phagocytosis and pinocytosis), exocytosis. Nucleic acids. DNA and RNA. Transcription and translation. Regulation of gene expression. Cell cycle. Types of cell division in prokaryotes and eukaryotes (mitosis and meiosis). Protein biosynthesis. Sexual reproduction and its evolutionary meaning. Tissues, stem cells and cancer. Genes that are critical for cancer development: proto-oncogenes and tumours suppressor genes.
(reference books)
Bruce Alberts, Karen Hopkin, Alexander D. Johnson, David Morgan, Martin Raff, Keith Roberts, Peter Walter. “Essential Cell Biology (Fifth Edition)”. Casa editrice: W. W. Norton & Company. 2019.
or
Peter H. Raven, George Johnson, Kenneth A. Mason, Jonathan B. Losos, Tod Duncan. “Biology”. Casa editrice: McGraw-Hill Education, 2019.
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Dates of beginning and end of teaching activities
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From to |
Delivery mode
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Traditional
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Attendance
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Mandatory
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Module: Radiobiology
(objectives)
The course aims to introduce the student to the radiological discipline and to provide him with basic knowledge of radiation physics and radiobiology
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Language
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ENG |
Type of certificate
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Profit certificate
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Credits
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1
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Scientific Disciplinary Sector Code
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MED/36
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Contact Hours
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10
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Type of Activity
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Core compulsory activities
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Teacher
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Ciabattoni Antonella
(syllabus)
• Definition and physical principles of Radiation and distinction between types of radiation (Non-Ionizing Radiation and Ionizing Radiation). • Main sources of natural and artificial radiation. Radioactivity and radioactive decay • Effects of radiation on DNA and mechanisms of repair of radio-induced damage; effects of radiation exposure to tissues, organs and the whole organism • Use of radiation in diagnostic imaging and radiotherapy
(reference books)
1. Radiobiology for the radiologist / Eric J. Hall, Amato J. Giaccia.—7th ed. 2. Bontrager’s Handbook of Radiographic Positioning and Techniques 9th Edition by Lampignano John; Kendrick, Leslie E.
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Dates of beginning and end of teaching activities
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From to |
Delivery mode
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Traditional
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Attendance
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Mandatory
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Module: Biochemistry
(objectives)
The aim of the teaching of BIOCHEMISTRY is to provide students with the fundamental knowledge relating to the structure of atoms and chemical elements and of the macromolecules necessary for the functioning and regulation of living organisms and their transformation processes. Put the student in a position to understand the basics of chemistry and cellular metabolism. The teaching also intends to provide the student with the fundamental knowledge relating to the basic concepts of chemistry, the structure of macromolecules underlying the metabolic processes necessary for the functioning and regulation of living organisms: carbohydrates, lipids, nucleic acids. To enable the student to understand the basics of cellular metabolism. The course aims to provide the student with some essential methods used in chemistry and biochemical practice and the theoretical principles on which these methodologies and their field of application are based.
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Language
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ENG |
Type of certificate
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Profit certificate
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Credits
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2
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Scientific Disciplinary Sector Code
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BIO/10
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Contact Hours
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20
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Type of Activity
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Basic compulsory activities
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Teacher
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Nicolai Eleonora
(syllabus)
• Structure / function of biological molecules: Structure of proteins: amino acids; peptide bond; primary structure; tertiary and quaternary secondary. Protein functions. Myoglobin and haemoglobin. Enzymes: characteristics and functioning; enzymatic inhibition mechanisms. • Glucose catabolism: the anaerobic catabolic pathway, glycolysis and fermentations. • The aerobic catabolic pathway: the Krebs cycle and oxidative phosphorylation. The regulation: hormones and vitamins • Fatty acid catabolism: Beta oxidation. Ketogenesis
(reference books)
1. ”Biochemistry”, D. R. Ferrier Wolters Kluwer; 2. “Lehningher principles of biochemistry”, D. L. Nelson, M.M. Cox (2017) W.H. Freeman & Co.
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Dates of beginning and end of teaching activities
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From to |
Delivery mode
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Traditional
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Attendance
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Mandatory
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Module: Clinical biochemistry and molecular biology
(objectives)
The teaching of Clinical Biochemistry and Clinical Molecular Biology aims to provide students with the theoretical-practical knowledge of the basic principles of Biochemistry and Molecular Biology underlying the execution and evaluation of laboratory diagnostic tests
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Language
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ENG |
Type of certificate
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Profit certificate
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Credits
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2
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Scientific Disciplinary Sector Code
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BIO/12
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Contact Hours
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20
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Type of Activity
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Basic compulsory activities
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Teacher
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Pieroni Luisa
(syllabus)
• Definition, limits and aims of Clinical Biochemistry and Clinical Molecular Biology as disciplines of Laboratory Medicine. • General organization of the Clinical Diagnostic Laboratory: from the request for analysis to the report. • Reference ranges, critical values • Sources of variability in the pre-analytical and analytical phase, intra and inter-individual biological variability, concepts of diagnostic sensitivity and specificity and their applications. Internal and external quality control • Balance of body fluids and electrolytes. Acid-base balance. Conditions associated with abnormal electrolyte composition or acid-base balance • Plasma proteins and enzymes as biomarkers of tissue and organ damage. Evaluation of plasma / serum enzymes and metabolites for diagnostic purposes. • Introduction to Clinical Molecular Biology and Molecular Biomarkers • Methods of preparation and analysis of proteins and nucleic acids in clinical diagnostics (E.g. immuno-detections and immunoassays of proteins, protein and nucleic acid electrophoresis, PCR, gene sequencing, arrays, LC-MS, etc) • Molecular diagnostic tests (genetic and oncological diseases)
(reference books)
1. Michael Laposata. “Laboratory Medicine: the diagnosis of disease in the clinical laboratory” (3rd edition). LANGE editor 2. Michael J. Murphy & Rajeev Srivastava & Kevin Deans “Clinical Biochemistry”, Sixth Edition , Elsevier
3. Michael M. Cox, Jennifer Doudna, Michael O'Donnell. “Molecular Biology: Principles and Practice”; W H Freeman & Co; 2
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Dates of beginning and end of teaching activities
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From to |
Delivery mode
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Traditional
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Attendance
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not mandatory
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Evaluation methods
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Written test
Oral exam
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Module: Genetics
(objectives)
The aim of the course of Medical Genetics is to provide to students the knowledge on the main notions on inheritance of monogenic, chromosomal and multifactorial diseases. At the end of the course, the student will be able to distinguish the main classes of genetic diseases and to recognize the modes of transmission of hereditary diseases.
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Language
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ENG |
Type of certificate
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Profit certificate
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Credits
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1
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Scientific Disciplinary Sector Code
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MED/03
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Contact Hours
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10
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Type of Activity
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Basic compulsory activities
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Teacher
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D'Apice Maria Rosaria
(syllabus)
Basic Genetics: Definitions of Key Terms: gene, locus, allele, genotype, phenotype, haplotype, homozygous, heterozygous, haploid, diploid, dominance, recessivity, codominance. Mutations and polymorphisms. Principles of Genetic Transmission: Mendel's Genetic Hypothesis, The Monohybrid Crosses, Segregation in Human Pedigrees, Blood groups Genetics Monogenic Inheritance Models: Autosomal Dominant inheritance, Autosomal recessive inheritance, X-linked inheritance Genetic Risk calculation and pedigrees Chromosomes: Structure and Analysis, Chromosomes Pathologies Multifactorial inheritance: polymorphisms, susceptibility genes, gene-environment interaction, association studies Genetic tests.
(reference books)
Recommended books: “Medical Genetics” by Lynn Jorde John Carey Michael Bamshad. Edited by Elsevier
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Dates of beginning and end of teaching activities
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From to |
Delivery mode
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Traditional
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Attendance
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Mandatory
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Module: Microbiology
(objectives)
Knowledge of the structure of the various microorganisms, of the microbial pathogenicity, of the causes and mechanisms of onset of the main microbial aetiologies are essential objectives. These objectives will be achieved through frontal lectures, seminars and interactive teaching activities, designed to facilitate learning and improve the ability to identify potential microbiological problems during professional activity.
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Language
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ENG |
Type of certificate
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Profit certificate
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Credits
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1
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Scientific Disciplinary Sector Code
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MED/07
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Contact Hours
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10
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Type of Activity
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Basic compulsory activities
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Teacher
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Armenia Daniele
(syllabus)
Basic principles of microbiology Morphology and structure of the bacterial cell Structure of bacterial spores and sporulation process Gram stain and staining for acid resistance Metabolism, growth and bacterial replication Sterilization, disinfection, asepsis Morphology of viral particles Cell tropism and host spectrum Viral enzymes Classification of viruses Stages of viral replication Mechanisms of bacterial pathogenesis Demonstration of causal nature between pathogen and disease: Koch postulates Normal microbial flora of our organism "Host-microorganism" interactions: Commensalism -Mutualism - Parasitism Factors that influence the "host -microrganism" balance Mode of transmission of the infection Stages of the infectious process Factors of bacterial virulence Mechanisms of viral pathogenesis and of interaction with the host: Transmission mode Stages of the infectious process Localized and disseminated infection State of persistence and latency Viral oncogenesis Cytopathic effect induced by viruses Expression of genes and / or cellular proteins
(reference books)
The basics of Microbiology Authors: Richard A. Harvey, Pamela C. Champe Bruce D. Fisher
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Dates of beginning and end of teaching activities
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From to |
Delivery mode
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Traditional
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Attendance
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Mandatory
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