Biology biochemistry and genetics
(objectives)
Knowledge of the main classes of organic compounds and biological macromolecules. Knowledge of the functioning of respiratory proteins. Knowledge of enzymes functioning and kinetics. Knowledge of the logic of energy metabolism in humans and the role played by the main classes of biomolecules. General knowledge of the main metabolic pathways and, in more detail, of the glucose catabolism pathways. The course aims to provide the student with the main notions on the inheritance of monogenic, chromosomal and multifactorial diseases. The student must acquire knowledge of the main methods of analysis useful for the diagnosis of these pathologies. It will also have to demonstrate the ability to analyse genealogical trees and clinical and genetic-molecular data for genetic counselling purposes.The Biology module aims at providing the students with the morphological and functional organization of prokaryotic and eukaryotic cells, focusing on both the descriptive aspects and the basic notions of biochemistry and cellular physiology required to understand the functions of the cell as a basic unit of living organisms. The objective of the course is the learning of the constructive logic of the biological structures at the different levels of organization of living matter, the principles that govern the functioning of the different biological systems, the learning of the experimental method and its applications to the study of biological phenomena. Students will learn the unitary mechanisms that regulate cellular activities, gene expression and genetic material transmission.
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Code
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90097 |
Language
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ENG |
Type of certificate
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Profit certificate
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Module: BIOCHEMISTRY
(objectives)
Knowledge of the main classes of organic compounds and biological macromolecules. Knowledge of the functioning of respiratory proteins. Knowledge of enzymes functioning and kinetics. Knowledge of the logic of energy metabolism in humans and the role played by the main classes of biomolecules. General knowledge of the main metabolic pathways and, in more detail, of the glucose catabolism pathways.
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Language
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ENG |
Type of certificate
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Profit certificate
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Credits
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2
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Scientific Disciplinary Sector Code
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BIO/10
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Contact Hours
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20
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Type of Activity
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Basic compulsory activities
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Teacher
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Federici Luca
(syllabus)
Recalls to the basic notions of general chemistry The structure of the atom. Chemical bonds. The main properties of aqueous solutions: measurement of concentration, pH, acid-base properties. Thermodynamics and chemical equilibrium. The chemical kinetics. The redox reactions. The chemistry of carbon Hybridization of orbitals: sp, sp2, sp3. Aliphatic and aromatic hydrocarbons. Chirality. Alcohols, aldehydes, ketones and carboxylic acids. Amines, esters, anhydrides and amides. Redox reactions in organic chemistry. Structure and function of biological molecules Carbohydrates: general aspects and classification, monosaccharides, oligosaccharides, polysaccharides. Lipids: general aspects and classification, fatty acids, acylglycerols, phosphoglycerides and sphingolipids, steroids. The biological membranes. Amino acids and the structure of proteins: amino acids; peptide bond; primary structure; tertiary and quaternary secondary school. Functions of proteins: Myoglobin and hemoglobin. Enzymes: characteristics and functioning; mechanisms of enzymatic inhibition. Carbohydrate metabolism: glycogen, glycolysis and gluconeogenesis. Hormonal regulation of blood sugar. Lipid metabolism: fatty acids as main fuels of metabolism, beta oxidation, ketone bodies, synthesis of fatty acids. Amino acid metabolism: digestion of proteins; transamination, deamination and urea production. Bioenergetics: citric acid cycle, respiratory chain, electron transfer and synthesis of ATP through ATP synthase.
(reference books)
-”Biochemistry”, D. R. Ferrier Wolters Kluwer; - “Lehningher principles of biochemistry”, D. L. Nelson, M.M. Cox (2017) W.H. Freeman & Co.
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Dates of beginning and end of teaching activities
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From to |
Delivery mode
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Traditional
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Attendance
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Mandatory
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Evaluation methods
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Written test
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Module: APPLIED BIOLOGY
(objectives)
The Biology module aims at providing the students with the morphological and functional organization of prokaryotic and eukaryotic cells, focusing on both the descriptive aspects and the basic notions of biochemistry and cellular physiology required to understand the functions of the cell as a basic unit of living organisms. The objective of the course is the learning of the constructive logic of the biological structures at the different levels of organization of living matter, the principles that govern the functioning of the different biological systems, the learning of the experimental method and its applications to the study of biological phenomena. Students will learn the unitary mechanisms that regulate cellular activities, gene expression and genetic material transmission.
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Language
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ENG |
Type of certificate
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Profit certificate
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Credits
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2
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Scientific Disciplinary Sector Code
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BIO/13
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Contact Hours
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20
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Type of Activity
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Basic compulsory activities
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Teacher
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Nardacci Roberta
(syllabus)
Characteristic of living cells: Cellular theory. Classification principles of living organisms. Prokaryotic and eukaryotic cell models: classification and major structural differences. Cell Chemistry: Macromolecules: structure, shape and function Plasma membrane: properties and functions. Internal organization of the cell: Cellular compartments. Cytoplasm and cytoplasmic organelles, ribosomes, smooth and rought endoplasmic reticulum, Golgi apparatus, lysosomes, peroxisomes. The cytoskeleton. Microtubules, intermediate filaments and microfilaments. Cilia and flagella. Centrioles and centrosomes. Energy conversion: Glycolysis, fermentation, cellular respiration, photosynthesis. (outline). Mitochondria and Chloroplasts, structure and function. Molecular basis of hereditary information: DNA replication. DNA repair and its correlation with human diseases. RNA, structure and function: Main types of cellular RNAs and differences with respect to DNA in terms of molecular size, stability and biological functions. Transcription and RNA maturation. Genetic Code and its properties. Protein synthesis: How cells read the genome. Main post-translational modifications of the polypeptide chains. Post-synthetic fate of proteins, endomembranes and membrane traffic: Endocytosis and exocytosis. Cell Cycle, Mitosis and Meiosis
(reference books)
- Essential Cell Biology (Fifth edition)
Authors: Bruce Alberts, Karen Hopkin, Alexander D Johnson, David Morgan, Martin Raff, Keith Roberts, Peter Walter
Editor: W.W. NORTON
or
- Biology
Authors: Peter H. Raven, George Johnson, Kenneth A. Mason, Jonathan B. Losos, Tod Duncan
Editor: McGraw-Hill Education
The indicated textbook is just a reference. Students are allowed to adopt the book/books of their choice. Additional material will be provided by the instructor.
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Dates of beginning and end of teaching activities
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From to |
Delivery mode
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Traditional
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Attendance
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Mandatory
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Evaluation methods
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Written test
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Module: MEDICAL GENETICS
(objectives)
The course aims to provide the student with the main notions on the inheritance of monogenic, chromosomal and multifactorial diseases. The student must acquire knowledge of the main methods of analysis useful for the diagnosis of these pathologies. It will also have to demonstrate the ability to analyse genealogical trees and clinical and genetic-molecular data for genetic counselling purposes.
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Language
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ENG |
Type of certificate
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Profit certificate
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Credits
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2
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Scientific Disciplinary Sector Code
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MED/03
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Contact Hours
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20
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Type of Activity
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Basic compulsory activities
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Teacher
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Ciccacci Cinzia
(syllabus)
Basic Genetics: Definitions of Key Terms: gene, locus, allele, genotype, phenotype, haplotype, homozygous, heterozygous, haploid, diploid, dominance, recessivity, codominance, mutation, polymorphism. Principles of Genetic Transmission: Mendel's Genetic Hypothesis, The Monohybrid and Dihybrid Crosses, Segregation in Human Pedigrees, Blood groups Genetics Monogenic Inheritance Models: Autosomal inheritance,Autosomal recessive inheritance, X-linked inheritance Genetic Risk calculation and pedigrees. Hardy-Weinberg Equilibrium Chromosomes: Structure and Analysis, Chromosomes Pathologies Genomic Imprinting X-chromosome inactivation Mitochondrial inheritance: mitochondrial DNA, pattern of inheritance Multifactorial inheritance: polimorphisms, susceptibility genes, gene-environment interaction, association studies Pharmacogenomics and Personalised Medicine Dynamic mutations and related disorders Genetic tests and Counselling. Outlines
(reference books)
Lectures in pdf format will be provided to students. Recommended books: “Medical Genetics” by Lynn Jorde John Carey Michael Bamshad. Edited by Elsevier
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Dates of beginning and end of teaching activities
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From to |
Delivery mode
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Traditional
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Attendance
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Mandatory
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Evaluation methods
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Written test
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