General and clinical pathology
(objectives)
The course of General and Clinical Pathology aims to provide students with the notions of general pathology and clinical pathology, also in the field of laboratory diagnosis. The student must learn the molecular mechanisms of cell damage, the response of the cell and the organism to damage, the molecular basis of the neoplastic transformation and progression, and some of the main disease markers that can be measured in a clinical laboratory. In addition, the student has to know the main techniques of molecular biology, flow cytometry and cytogenetics for the diagnosis and monitoring of blood diseases and the role of laboratory activities for an integrated clinical management of the hematological patient. These objectives will be achieved through lectures designed to facilitate learning and improve the ability to address and resolve the main questions of general, cellular and clinical pathology and the diagnostic questions from the oncohematology laboratory, which the student will have to face during his future activity.
|
Code
|
90331 |
Language
|
ITA |
Type of certificate
|
Profit certificate
|
Module: General and cellular pathology
(objectives)
The student must learn the molecular mechanisms of cell damage, the response of the cell and the organism to damage, the molecular basis of the neoplastic transformation and progression. These objectives will be achieved through lectures designed to facilitate learning and improve the ability to address and resolve the main questions of general and cellular pathology.
|
Language
|
ITA |
Type of certificate
|
Profit certificate
|
Credits
|
2
|
Scientific Disciplinary Sector Code
|
MED/04
|
Contact Hours
|
20
|
Type of Activity
|
Core compulsory activities
|
Teacher
|
Wolf Federica
(syllabus)
Classification of diseases on an etiopathogenetic basis, extrinsic agents (physical, chemical, biological) and intrinsic agents (genetic and malformative diseases). Multifactorial diseases. Basic concepts of cellular pathology: death from necrosis and apoptosis. Innate immunity: acute and chronic inflammation, vascular events, exudates, outcomes. Chronic interstitial and granulomatous inflammation. Repair. Basic concepts of health and disease, approach to the patient, disease classification criteria of interest to the general pathology. Adaptations: hypertrophy, hyperplasia, metaplasia, dysplasia, neoplasia. Tumors: biological and clinical classification criteria. Biological characteristics of tumors: proliferation, invasion, angiogenesis. Metastatization, metastasis sites. Cancerogenesis, oncogenes and tumor suppressors, concept of tumor marker.
(reference books)
-Slides and didactic materials provided by the teacher -Textbook: Ivan Damjanov MD PhD, Pathology for the Health Professions, 5th Edition, Elsevier; ISBN: 9780323357210; 2016.
|
Dates of beginning and end of teaching activities
|
From to |
Delivery mode
|
Traditional
|
Attendance
|
Mandatory
|
Evaluation methods
|
Written test
Oral exam
|
Teacher
|
Toniato Elena
(syllabus)
Classification of diseases on an etiopathogenetic basis, extrinsic agents (physical, chemical, biological) and intrinsic agents (genetic and malformative diseases). Multifactorial diseases. Basic concepts of cellular pathology: death from necrosis and apoptosis. Innate immunity: acute and chronic inflammation, vascular events, exudates, outcomes. Chronic interstitial and granulomatous inflammation. Repair. Basic concepts of health and disease, approach to the patient, disease classification criteria of interest to the general pathology. Adaptations: hypertrophy, hyperplasia, metaplasia, dysplasia, neoplasia. Tumors: biological and clinical classification criteria. Biological characteristics of tumors: proliferation, invasion, angiogenesis. Metastatization, metastasis sites. Cancerogenesis, oncogenes and tumor suppressors, concept of tumor marker.
(reference books)
-Slides and didactic materials provided by the teacher -Textbook: Ivan Damjanov MD PhD, Pathology for the Health Professions, 5th Edition, Elsevier; ISBN: 9780323357210; 2016.
|
Dates of beginning and end of teaching activities
|
From to |
Delivery mode
|
Traditional
|
Attendance
|
Mandatory
|
Evaluation methods
|
Written test
Oral exam
|
|
|
Module: Clinical pathology and immunohematology
(objectives)
The teaching of Clinical Pathology examines the study of some of the main disease markers that can be measured in a clinical laboratory
|
Language
|
ITA |
Type of certificate
|
Profit certificate
|
Credits
|
3
|
Scientific Disciplinary Sector Code
|
MED/05
|
Contact Hours
|
30
|
Type of Activity
|
Core compulsory activities
|
Teacher
|
Moriconi Luca
(syllabus)
• Interpretation of laboratory tests • Renal function tests • Examination of Urine • Liver function tests • Laboratory tests in Diabetes Mellitus • Thyroid function tests • Laboratory tests in disorders of lipids • Laboratory tests in Pregnancy • Laboratory tests in bleeding disorders and thrombophilia • Laboratory tests in autoimmune disease • Laboratory tests in anemia and hematological malignancies • Practical blood transfusion • Tumor markers.
(reference books)
Teaching material provided by the teacher -Textbooks : -Kawthalkar, Shirish M., M.D., Essentials of Clinical Pathology, Jaypee Brothers Medical Pub; 2nd edition (31 July 2018); ISBN-13: 978-9386150691 -Daniel D. Mais, Quick Compendium of Clinical Pathology, ASCP Press; 4th Revised edition (30 December 2018); ISBN-13: 978-0891896678.
|
Dates of beginning and end of teaching activities
|
From to |
Delivery mode
|
Traditional
|
Attendance
|
Mandatory
|
Evaluation methods
|
Written test
Oral exam
|
Teacher
|
Romeo Anna Claudia
(syllabus)
• Interpretation of laboratory tests • Renal function tests • Examination of Urine • Liver function tests • Laboratory tests in Diabetes Mellitus • Thyroid function tests • Laboratory tests in disorders of lipids • Laboratory tests in Pregnancy • Laboratory tests in bleeding disorders and thrombophilia • Laboratory tests in autoimmune disease • Laboratory tests in anemia and hematological malignancies • Practical blood transfusion • Tumor markers.
(reference books)
-Teaching material provided by the teacher -Textbooks : -Kawthalkar, Shirish M., M.D., Essentials of Clinical Pathology, Jaypee Brothers Medical Pub; 2nd edition (31 July 2018); ISBN-13: 978-9386150691 -Daniel D. Mais, Quick Compendium of Clinical Pathology, ASCP Press; 4th Revised edition (30 December 2018); ISBN-13: 978-0891896678.
|
Dates of beginning and end of teaching activities
|
From to |
Delivery mode
|
Traditional
|
Attendance
|
Mandatory
|
Evaluation methods
|
Written test
Oral exam
|
|
|
Module: Technical sciences of laboratory medicine
(objectives)
The specific educational objectives of the course include the acquisition of the main techniques of molecular biology, flow cytometry and cytogenetics for the diagnosis and monitoring of blood diseases. It also explores the role of laboratory activities for an integrated clinical management of the hematological patient. The course aims to provide the fundamental technical knowledge in all the laboratory sectors applied to Oncohematology , in particular to Cytofluorimetry, Molecular Biology and Cytogenetics. The objectives will be achieved through lectures and interactive educational activities,designed to facilitate learning and improve the ability to deal with and resolve the main ones diagnostic questions from the oncohematology laboratory.
|
Language
|
ITA |
Type of certificate
|
Profit certificate
|
Credits
|
2
|
Scientific Disciplinary Sector Code
|
MED/46
|
Contact Hours
|
20
|
Type of Activity
|
Core compulsory activities
|
Teacher
|
Divona Mariadomenica
(syllabus)
• Introduction to Integrated Onco-hematological diagnostics: Flow cytometric techniques, Molecular biology, Conventional cytogenetics,Fluorescent in situ hybridization (FISH) • Separation of mononuclear cells from bone marrow aspirate and peripheral blood (Ficoll) • Count of cells with counting chambers • Nucleic acid extraction techniques (automatic extractors, home made techniques) • RT-PCR: basic principles and technical aspects • Application of PCR in oncohematology • PCR real-time: basic principles and technical aspects • Application of real-time PCR in monitoring the minimal residual disease • Q-LAMP : basic principles and technical aspects • Application of Q-LAMP in the rapid diagnosis of Acute Promyelocytic Leukemia • Eletrroforetic techniques : agarose gel electrophoresis, capillary electrophoresis • Case-report in the validation of the analytical data.
(reference books)
Didactic materials provided by the teacher.
|
Dates of beginning and end of teaching activities
|
From to |
Delivery mode
|
Traditional
|
Attendance
|
Mandatory
|
Evaluation methods
|
Written test
Oral exam
|
|
|
|