Biology biochemistry and genetics
(objectives)
BIOCHEMISTRY Knowledge of the main classes of organic compounds and biological macromolecules. Knowledge of the functioning of respiratory proteins. Knowledge of enzymes functioning and kinetics. Knowledge of the logic of energy metabolism in humans and the role played by the main classes of biomolecules. General knowledge of the main metabolic pathways and, in more detail, of the glucose catabolism pathways MEDICAL GENETIC The course aims to provide the student with the main notions on the inheritance of monogenic, chromosomal and multifactorial diseases. The student must acquire knowledge of the main methods of analysis useful for the diagnosis of these pathologies. It will also have to demonstrate the ability to analyse genealogical trees and clinical and genetic-molecular data for genetic counselling purposes. APPLIED BIOLOGY The Biology module aims at providing the students with the morphological and functional organization of prokaryotic and eukaryotic cells, focusing on both the descriptive aspects and the basic notions of biochemistry and cellular physiology required to understand the functions of the cell as a basic unit of living organisms. The objective of the course is the learning of the constructive logic of the biological structures at the different levels of organization of living matter, the principles that govern the functioning of the different biological systems, the learning of the experimental method and its applications to the study of biological phenomena. Students will learn the unitary mechanisms that regulate cellular activities, gene expression and genetic material transmission.
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Code
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90097 |
Language
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ENG |
Type of certificate
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Profit certificate
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Module: BIOCHEMISTRY
(objectives)
Knowledge of the main biological macromolecules. Knowledge of enzymes functioning and kinetics. General knowledge of the main metabolic pathways and, in more detail, of the glucose catabolism pathways.
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Language
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ENG |
Type of certificate
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Profit certificate
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Credits
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2
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Scientific Disciplinary Sector Code
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BIO/10
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Contact Hours
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20
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Type of Activity
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Basic compulsory activities
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Teacher
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Mei Giampiero
(syllabus)
A. Structure / function of biological molecules Protein structure: amino acids; peptide bond; primary structure; secondary tertiary and quaternary. Functions of proteins. Myoglobin and and moglobin. Enzymes: characteristics and functioning; mechanisms of enzymatic inhibition.
B. Glucose catabolism The anaerobic catabolic pathway: glycolysis and fermentation The aerobic catabolic pathway: the Krebs cycle and oxidative phosphorylation The regulation: hormones and vitamins
C. Catabolism of fatty acids Beta oxidation Ketogenesis
(reference books)
- " Biochemistry ", DR Ferrier Wolters Kluwer; - " Lehningher principles of biochemistry ", DL Nelson, MM Cox (2017) Ed. WH Freeman & Co.
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Dates of beginning and end of teaching activities
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From to |
Delivery mode
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Traditional
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Attendance
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Mandatory
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Module: APPLIED BIOLOGY
(objectives)
The Biology module aims at providing the students with the morphological and functional organization of prokaryotic and eukaryotic cells, focusing on both the descriptive aspects and the basic notions of biochemistry and cellular physiology required to understand the functions of the cell as a basic unit of living organisms. The objective of the course is the learning of the constructive logic of the biological structures at the different levels of organization of living matter, the principles that govern the functioning of the different biological systems, the learning of the experimental method and its applications to the study of biological phenomena. Students will learn the unitary mechanisms that regulate cellular activities, gene expression and genetic material transmission.
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Language
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ENG |
Type of certificate
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Profit certificate
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Credits
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2
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Scientific Disciplinary Sector Code
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BIO/13
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Contact Hours
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20
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Type of Activity
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Basic compulsory activities
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Teacher
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Nardacci Roberta
(syllabus)
Characteristic of living cells: Cellular theory. Classification principles of living organisms. Prokaryotic and eukaryotic cell models: classification and major structural differences. Cell Chemistry: Macromolecules: structure, shape and function Plasma membrane: properties and functions. Internal organization of the cell: Cellular compartments. Cytoplasm and cytoplasmic organelles, ribosomes, smooth and rought endoplasmic reticulum, Golgi apparatus, lysosomes, peroxisomes. The cytoskeleton. Microtubules, intermediate filaments and microfilaments. Cilia and flagella. Centrioles and centrosomes. Energy conversion: Glycolysis, fermentation, cellular respiration, photosynthesis. (outline). Mitochondria and Chloroplasts, structure and function. Molecular basis of hereditary information: DNA replication. DNA repair and its correlation with human diseases. RNA, structure and function: Main types of cellular RNAs and differences with respect to DNA in terms of molecular size, stability and biological functions. Transcription and RNA maturation. Genetic Code and its properties. Protein synthesis: How cells read the genome. Main post-translational modifications of the polypeptide chains. Post-synthetic fate of proteins, endomembranes and membrane traffic: Endocytosis and exocytosis. Cell Cycle, Mitosis and Meiosis
(reference books)
• Sadava, Hillis, Heller, Hacker. Elementi di Biologia e Genetica Zanichelli editore, V ed. • Raven,Johnson, Mason, Losos, Singer. Elementi di Biologia e Genetica Piccin editore II ed.
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Dates of beginning and end of teaching activities
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From to |
Delivery mode
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Traditional
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Attendance
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Mandatory
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Module: MEDICAL GENETICS
(objectives)
The aim of the course of Medical Genetics is to provide to students the knowledge on the main notions on inheritance of monogenic, chromosomal and multifactorial diseases. At the end of the course the student will be able to distinguish the main classes of genetic diseases and to recognize the modes of transmission of hereditary diseases.
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Language
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ENG |
Type of certificate
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Profit certificate
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Credits
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2
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Scientific Disciplinary Sector Code
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MED/03
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Contact Hours
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20
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Type of Activity
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Basic compulsory activities
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Teacher
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Ciccacci Cinzia
(syllabus)
Basic Genetics: Definitions of Key Terms: gene, locus, allele, genotype, phenotype, haplotype, homozygous, heterozygous, haploid, diploid, dominance, recessivity, codominance, mutation, polymorphism. Principles of Genetic Transmission: Mendel's Genetic Hypothesis, The Monohybrid and Dihybrid Crosses, Segregation in Human Pedigrees, Blood groups Genetics Monogenic Inheritance Models: Autosomal inheritance,Autosomal recessive inheritance, X-linked inheritance Genetic Risk calculation and pedigrees. Hardy-Weinberg Equilibrium Chromosomes: Structure and Analysis, Chromosomes Pathologies Genomic Imprinting X-chromosome inactivation Mitochondrial inheritance: mitochondrial DNA, pattern of inheritance Multifactorial inheritance: polimorphisms, susceptibility genes, gene-environment interaction, association studies Pharmacogenomics and Personalised Medicine Dynamic mutations and related disorders Genetic tests and Counselling. Outlines
(reference books)
Lectures in pdf format will be provided to students. Recommended books: “Medical Genetics” by Lynn Jorde John Carey Michael Bamshad. Edited by Elsevier
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Dates of beginning and end of teaching activities
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From to |
Delivery mode
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Traditional
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Attendance
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Mandatory
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