I.C. Biological and biochemical foundations of living systems
(objectives)
The purpose of the course is to provide students with: -The basic concepts of Biochemistry, involved in the structure of macromolecules (carbohydrates, proteins, lipids and nucleic acids) and biochemical events involved in cellular metabolism. -The basic knowledge of the cellular and molecular biology of eukaryotic cells that are crucial to understand, later, the physiology, both from the cellular and tissutal perspective.
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Code
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90171 |
Language
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ENG |
Type of certificate
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Profit certificate
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Module: Applied biology
(objectives)
Comprehension and knowledge of chemico-physical and molecular mechanisms which are at the base of vital processes. Knowledge of chemical compounds and comprehension of chemical reactions involved in biological processes.
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Language
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ENG |
Type of certificate
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Profit certificate
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Credits
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2
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Scientific Disciplinary Sector Code
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BIO/13
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Contact Hours
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20
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Type of Activity
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Basic compulsory activities
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Teacher
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Michienzi Alessandro
(syllabus)
• General characteristics of living organisms (autotrophic and heterotrophic, aerobic and anaerobic bacteria, unicellular and multicellular, eukaryotic and prokaryotic). Cell theory. • chemical constituents of cells: water; hydrophilic, hydrophobic and amphipathic molecules • Structure and function of biological macromolecules: carbohydrates, lipids, proteins, nucleic acids. • Organization of the fundamental eukaryotic cell and prokaryotic. Viruses • Cellular compartments and related functional specialization (core; ribosomes, mitochondria, chloroplasts, endoplasmic reticulum; the Golgi complex, lysosomes, cytoskeleton; vacuoles). • Structure and general functions of cell membranes • Diffusion, passive transport and active transport (channel protein, sodium-potassium pump, secondary active transport) • From genotype to phenotype: DNA as genetic material, structure and function • DNA transcription, RNA maturation. • The genetic code: property (universality, non-ambiguity, continuity, redundancy or degeneracy) and reading mode. • Protein biosynthesis. • Regulation of gene expression in eukaryotes • Cellular reproduction: cell cycle, DNA replication and mitosis. • Regulation of the cell cycle, tumor suppressor, oncogenes • Sexual reproduction: Meiosis
(reference books)
-Essential Cell Biology-Alberts-Fourth Edition-Garland Science/Taylor and Francis Group
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Dates of beginning and end of teaching activities
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From to |
Delivery mode
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Traditional
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Attendance
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Mandatory
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Evaluation methods
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Written test
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Module: Radiobiology
(objectives)
The course aims to provide the student with the skills and knowledge necessary for an approach to work in the field of diagnostic imaging and the use of ionizing radiation.
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Language
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ENG |
Type of certificate
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Profit certificate
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Credits
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1
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Scientific Disciplinary Sector Code
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MED/36
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Contact Hours
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10
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Type of Activity
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Core compulsory activities
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Teacher
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Chiaravalloti Agostino
(syllabus)
Radiation Definition and physical principles of Radiation and distinction between types of radiation (Non-Ionizing Radiation and Ionizing Radiation; main sources of natural and artificial radiation. Radioactivity and radioactive decay. Use of radiation in diagnostic imaging and therapy. Primary exposure factors, secondary exposure factors. Law of the Inverse of the Square of Distance
Radiobiology Introduction to cell biology and cell proliferation mechanisms. Effects of radiation on DNA and mechanisms for repairing radio-induced damage. Chromosome aberrations. Inactivation of cellular proliferative capacity. Theories and models of cell survival. Apoptosis, mutations and neoplastic transformation by radiation. Genomic instability. Effects of radiation exposure of tissues, organs and the entire body. Acute effects: radiosensitivity of tissues and organs. Panirradiation syndromes. Prenatal effects. Long-term effects: stochastic and non-stochastic effects. Non-stochastic effects in tissues and organs. Stochastic effects: radiocancerogenesis in experimental animal systems and in human populations (epidemiological data for natural or artificial radiation sources), genetic effects.
(reference books)
Hall, Eric J. Radiobiology for the radiologist / Eric J. Hall, Amato J. Giaccia.—7th ed.
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Dates of beginning and end of teaching activities
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From to |
Delivery mode
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Traditional
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Attendance
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Mandatory
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Evaluation methods
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Written test
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Module: Biochemistry
(objectives)
Knowledge of the main biological macromolecules. Knowledge of enzymes functioning and kinetics.General knowledge of the main metabolic pathways and, in more detail, of the glucose catabolism pathways
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Language
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ENG |
Type of certificate
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Profit certificate
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Credits
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2
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Scientific Disciplinary Sector Code
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BIO/10
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Contact Hours
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20
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Type of Activity
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Basic compulsory activities
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Teacher
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Mei Giampiero
(syllabus)
A. Structure / function of biological molecules Protein structure: amino acids; peptide bond; primary structure; secondary tertiary and quaternary. Functions of proteins. Myoglobin and and moglobin. Enzymes: characteristics and functioning; mechanisms of enzymatic inhibition.
B. Glucose catabolism The anaerobic catabolic pathway: glycolysis and fermentation The aerobic catabolic pathway: the Krebs cycle and oxidative phosphorylation The regulation: hormones and vitamins
C. Catabolism of fatty acids Beta oxidation Ketogenesis
(reference books)
- ”Biochemistry”, D. R. Ferrier Wolters Kluwer;
- “Lehningher principles of biochemistry”, D. L. Nelson, M.M. Cox (2017) W.H. Freeman & Co.
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Dates of beginning and end of teaching activities
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From to |
Delivery mode
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Traditional
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Attendance
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Mandatory
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Evaluation methods
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Written test
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Module: Clinical biochemistry and molecular biology
(objectives)
Knowledge of the main clinical biological and biochemical
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Language
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ENG |
Type of certificate
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Profit certificate
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Credits
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2
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Scientific Disciplinary Sector Code
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BIO/12
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Contact Hours
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20
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Type of Activity
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Basic compulsory activities
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Teacher
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Sbardella Diego
(syllabus)
Introduction remarks. Periodic table of elements and inorganic nomenclature. Atom: atom models, atomic particles: proton, neutron, electron. Isotopes. Electrons and atom electronic configuration. The quantum-mechanical model of the atom. Quantum numbers and orbitals. Auf-bau. Chemical bonds. Matter states. Gas: ideal gas law. Absolute temperature and its relation with mean molecular speed. Mixture of gases; Dalton law. Liquids: vapor pressure of a liquid. Solids: structural characteristics of covalent, ionic, molecular and metallic solids. Solutions. Concentrations of solutions: dilution and mixing of solutions. Vapor pressure of a solution (Raoult law). Solubility of gases in liquids: Henry law. Chemical equilibrium. Equilibrium in gaseous phase. Expression of equilibrium constant. Kp and Kc relationship. Equilibrium influencing factors. Homogeneus and hetherogeneus equilibrium. Solutions of electrolytes. Strong and weak electrolytes: dissociation grade. Colligative properties of electrolyte solutions. Van't Hoff binomial. Acid and bases following Arrhenius, Bronsted and Lowry definitions. Strong and weak acid and bases. pH in strong and weak acid and base solutions. Buffers. Acid-base titrations. Heterogeneous systems. Equilibria of slightly soluble ionic compounds. The solubility-product constant. The effect of a common ion. Carbon atom hybridization. Hydrocarbons. Aromatic compounds. Benzene structure: resonance model. Aromatic compounds nomenclature. Alcohols, phenols, thiols. Nomenclature. Thiols. Aldehydes and ketones. Nomenclature. Aldehydes and ketones preparation. Carbonylic group. Acetals and hemiacetals formationAldol condensation. Carboxylic acids and their derivatives. Nomenclature. Carboxylic acid derivatives: esters, anhydrides, amides. Carbohydrates, Lipids, Amino acids, Proteins and Vitamins. Principles of energetic metabolism.
(reference books)
Peter Atkins , Loretta Jones, Leroy Laverman Chemical Principles: The Quest for Insight Chemistry by M.S. Silderberg, McGraw-Hill International Edition.
Katherine J Denniston, Joseph J Topping and Robert L Caret. General, Organic & Biochemistry. 7th Ed. 2010. McGraw-Hill Higher Education.
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Dates of beginning and end of teaching activities
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From to |
Delivery mode
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Traditional
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Attendance
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Mandatory
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Module: Genetics
(objectives)
The aims of the course of Medical Genetics is to provide to students the knowledge on the main notions on inheritance of monogenic, chromosomal and multifactorial diseases. At the end of the course the student will have to know the main methods of analysis for the diagnosis of these disorders. He should show capacity to analyse pedigrees and clinical and molecular genetic data useful for genetic counselling and to know the major kind of genetic testing and their proper use.
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Language
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ENG |
Type of certificate
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Profit certificate
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Credits
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1
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Scientific Disciplinary Sector Code
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MED/03
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Contact Hours
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10
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Type of Activity
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Basic compulsory activities
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Teacher
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Ciccacci Cinzia
(syllabus)
Basic Genetics: Definitions of Key Terms, Polymorphisms and mutations; Blood groups Genetics Principles of Genetic Transmission: Mendel's Genetic Hypothesis, The Monohybrid Crosses, Segregation of Two or More Genes, Segregation in Human Pedigrees Monogenic Inheritance Models: Autosomal dominant inheritance, Autosomal recessive inheritance, X-linked inheritance (dominant and recessive), Y-linked inheritance Genetic Risk calculation and pedigrees Chromosome: Structure and Analysis, Chromosome Pathologies. Multifactorial diseases: an overview Genetic tests and Counselling.
(reference books)
"Medical Genetics" by Jorde - Carey – Bamshad
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Dates of beginning and end of teaching activities
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From to |
Delivery mode
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Traditional
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Attendance
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Mandatory
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Evaluation methods
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Written test
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Module: Microbiology
(objectives)
The course aims to provide skills to fully understand the structure, metabolism, genetics and pathogenicity of Viruses, Bacteria
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Language
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ENG |
Type of certificate
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Profit certificate
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Credits
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1
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Scientific Disciplinary Sector Code
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MED/07
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Contact Hours
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10
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Type of Activity
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Basic compulsory activities
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Teacher
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Armenia Daniele
(syllabus)
Basic principles of microbiology Morphology and structure of the bacterial cell Structure of bacterial spores and sporulation process Gram stain and staining for acid resistance Metabolism, growth and bacterial replication Sterilization, disinfection, asepsis Morphology of viral particles Cell tropism and host spectrum Viral enzymes Classification of viruses Stages of viral replication Mechanisms of bacterial pathogenesis Demonstration of causal nature between pathogen and disease: Koch postulates Normal microbial flora of our organism "Host-microorganism" interactions: Commensalism -Mutualism - Parasitism Factors that influence the "host -microrganism" balance Mode of transmission of the infection Stages of the infectious process Factors of bacterial virulence Mechanisms of viral pathogenesis and of interaction with the host: Transmission mode Stages of the infectious process Localized and disseminated infection State of persistence and latency Viral oncogenesis Cytopathic effect induced by viruses Expression of genes and / or cellular proteins
(reference books)
Title: The basics of Microbiology Authors: Richard A. Harvey, Pamela C. Champe Bruce D. Fisher
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Dates of beginning and end of teaching activities
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From to |
Delivery mode
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Traditional
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Attendance
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Mandatory
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Evaluation methods
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Written test
Oral exam
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