| Biology biochemistry and genetics
(objectives)
At the end of the integrated course of biology, applied Physics, biochemistry the student must be able to describe the morphological and physiological characteristics of the cells, the metabolic processes that contribute to the normal functioning of the organism through the understanding of the biochemical phenomena regulating human life and their clinical modifications. It will also have to understand the basics of physics, with a particular insight into fluid dynamics.
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Code
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90097 |
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Language
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ENG |
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Type of certificate
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Profit certificate
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| Module: BIOCHEMISTRY
(objectives)
At the end of the course the student must be able to identify the states of the matter and the significance of the chemical solutions and concentrations; it must also be able to know the organic and inorganic composition of the human organism, the general characters and the biological role of the main elements of organic chemistry.
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Language
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ENG |
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Type of certificate
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Profit certificate
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Credits
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2
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Scientific Disciplinary Sector Code
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BIO/10
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Contact Hours
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20
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Type of Activity
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Basic compulsory activities
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Teacher
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Mei Giampiero
(syllabus)
A – Fundamentals of Chemistry:
Atomic structure. Definition of oxides, acids, bases and salts. Examples. The valence. Covalent and hydrogen bonds. The properties of water. Osmosis. pH. Molar concentration of solutes. The fundamental chemical groups of organic molecules.
B – Fundamentals of structural Biochemistry:
Proteins structure and function. Enzymes. Carbohydrates. Fatty acids. Vitamins and hormones. Nucleic acids.
C – Fundamentals of methabolic processes:
Reducing power: NADH, NADPH, FADH2. Introduction to metabolism: Glycolysis. Krebs cycle. Fatty acid catabolism. The respiratory chain.
(reference books)
"Biochemistry" D.R.Ferrier - Wolter Kluwer Edition
"Lehningher principles of biochemistry, 2017" D.L.Nelson, M.M. Cox - W.H.Freeman & Co. Ed.
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Dates of beginning and end of teaching activities
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From to |
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Delivery mode
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Traditional
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Attendance
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Mandatory
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Evaluation methods
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Written test
Oral exam
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| Module: APPLIED BIOLOGY
(objectives)
The purpose of the course is to provide students with:
-The basic concepts of Biochemistry, involved in the structure of macromolecules (carbohydrates, proteins, lipids and nucleic acids) and biochemical events involved in cellular metabolism.
-The basic knowledge of the cellular and molecular biology of eukaryotic cells that are crucial to understand, later, the physiology, both from the cellular and tissutal perspective .
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Language
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ENG |
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Type of certificate
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Profit certificate
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Credits
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2
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Scientific Disciplinary Sector Code
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BIO/13
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Contact Hours
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20
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Type of Activity
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Basic compulsory activities
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Teacher
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Galardi Silvia
(syllabus)
• General characteristics of living organisms (autotrophic and heterotrophic, aerobic and anaerobic bacteria, unicellular and multicellular, eukaryotic and prokaryotic). Cell theory.
• chemical constituents of cells: water; hydrophilic, hydrophobic and amphipathic molecules
• Structure and function of biological macromolecules: carbohydrates, lipids, proteins, nucleic acids.
• Organization of the fundamental eukaryotic cell and prokaryotic. Viruses
• Cellular compartments and related functional specialization (core; ribosomes, mitochondria, chloroplasts, endoplasmic reticulum; the Golgi complex, lysosomes, cytoskeleton; vacuoles).
• Structure and general functions of cell membranes
• Diffusion, passive transport and active transport (channel protein, sodium-potassium pump, secondary active transport)
• From genotype to phenotype: DNA as genetic material, structure and function
• DNA transcription, RNA maturation.
• The genetic code: property (universality, non-ambiguity, continuity, redundancy or degeneracy) and reading mode.
• Protein biosynthesis.
• Regulation of gene expression in eukaryotes
• Cellular reproduction: cell cycle, DNA replication and mitosis.
• Regulation of the cell cycle, tumor suppressor, oncogenes
• Sexual reproduction: Meiosis
(reference books)
Essential Cell Biology, IV edition, Alberts et al, Garland and Science
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Dates of beginning and end of teaching activities
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From to |
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Delivery mode
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Traditional
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Attendance
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Mandatory
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Evaluation methods
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Written test
Oral exam
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| Module: MEDICAL GENETICS
(objectives)
The aims of the course of Medical Genetics is to provide to students the knowledge on the main notions on inheritance of monogenic, chromosomal and multifactorial diseases.
At the end of the course the student will have to know the main methods of analysis for the diagnosis of these disorders. He should show capacity to analyse pedigrees and clinical and molecular genetic data useful for genetic counselling and to know the major kind of genetic testing and their proper use.
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Language
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ENG |
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Type of certificate
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Profit certificate
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Credits
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2
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Scientific Disciplinary Sector Code
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MED/03
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Contact Hours
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20
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Type of Activity
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Basic compulsory activities
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Teacher
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Ciccacci Cinzia
(syllabus)
Basic Genetics:Definitions of Key Terms, Polymorphisms and mutations.
Principles of Genetic Transmission: Mendel's Genetic Hypothesis, The Monohybrid Crosses, Segregation of Two or More Genes, Segregation in Human Pedigrees. Blood groups Genetics
Monogenic Inheritance Models: Autosomal dominant inheritance, Autosomal recessive inheritance, X-linked inheritance, Y linked inheritance
Genetic Risk calculation and pedigrees
Genomic Imprinting
X chromosome inactivation
Chromosome: Structure and Analysis, Chromosome Pathologies
The genetics of complex diseases: Concept of Genomic biomarker, inter-individual variability, Genetic approaches to investigate complex diseases
Pharmacogenetics and Pharmacogenomics: The role of genetic variability in the response to drugs, both in terms of efficacy and toxicity
Genetic counselling
Genetics of neurologic diseases
(reference books)
"Medical Genetics" by Jorde, Carey, Bamshad.
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Dates of beginning and end of teaching activities
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From to |
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Delivery mode
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Traditional
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Attendance
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Mandatory
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Evaluation methods
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Written test
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