Ponterio Giulia

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Giulia Ponterio, PhD Personal Informations Date of birth: 22/06/1984, Rome Nationality: Italian E-mail: giulia.ponterio@unicamillus.org ; g.ponterio@hsantalucia.it Education and training A.A. 2010/2011 - A.A. 2012/2013 Neuroscience Course (XXVI cycle), Faculty of Medicine and Surgery, University of Rome “Tor Vergata”. Title achieved: PhD in Neuroscience, 07/02/2014. 2012 Professional biologist qualification. Enrolled in the National Biology Order (ONB) A.A. 2007/2008 - A.A. 2008/2009, Faculty of Medicine and Surgery, University of Rome “Tor Vergata”. Title achieved: Master Degree in Medical Biotechnology, 11/05/2010. Graduation vote: 110/110 cum laude. A.A. 2003/2004 - A.A. 2006/2007, Faculty of Physical and Natural Mathematical Sciences, University of Rome “Tor Vergata”. Title achieved: Bachelor Degree in Biotechnology, 19/07/2007. A.A. 1998/1999 – A.A. 2002/2003 Classical High school, “Pilo Albertelli” Rome. Title achieved: diploma, 09/07/2003. Positions, Scientific Appointments and Honors 2021 – Present: Postdoctoral Researcher, Fondazione Santa Lucia, IRCCS, Rome, Italy 2018 – 2020: Postdoctoral Fellowship University of Rome Tor Vergata, Rome, Italy 2016-2016: Postdoctoral Researcher collaborator, Fondazione Santa Lucia, Rome, Italy 2014 – 2016: Postdoctoral Fellowship University of Rome Tor Vergata, Rome, Italy 2013-2013: Predoctoral Fellow Universitè Bordeaux 2, Istitute des Maladies Neurodegenrative, Bordeaux, France 2011-2012: Predoctoral Fellow University of Rome Tor Vergata, Rome, Italy Honors -2010 Graduation in in Medical Biotechnology with Honors, University of Rome Tor Vergata -2012 Travel Grant Dystonia Summer School Bol, Croazia -2013 Stipend Grant Short Term Scientific Mission, COST Dystonia European Network, Bordeaux, France -2016 Travel Grant SINS, FENS Forum Copenaghen, Denmark -2019 Travel Grant SINS, Perugia, Italy Other experience and Professional Membership - Editorial activity: Editor reviewer Frontiers Molecular Neuroscience; Guest editor Metabolities, MDPI journal - Member of SINS Scopus Author Id:38862642100 ORCID ID:0000-0001-5886-3368 RESEARCH ID: K-2114-2016 Publications 1. Tassone A, Meringolo M, Ponterio G, Bonsi P, Schirinzi T, Martella G. Mitochondrial Bioenergy in Neurodegenerative Disease: Huntington and Parkinson. Int J Mol Sci. 2023;24(8):7221. 2. El Atiallah I, Bonsi P, Tassone A, Martella G, Biella G, Castagno AN, Pisani A, Ponterio G. Synaptic dysfunction in dystonia: update from experimental models. Current Neuropharmacology 2023; in press 3. Ponterio G, Faustini G, El Atiallah I, Sciamanna G, Meringolo M, Tassone A, Imbriani P, Cerri S, Martella G, Bonsi P, Bellucci A, Pisani A. Alpha-Synuclein is Involved in DYT1 Dystonia Striatal Synaptic Dysfunction. Mov Disord. 2022;37(5):949-961. 4. Sciamanna G*, Ponterio G*, Tassone A, Maltese M, Madeo G, Martella G, Poli S, Schirinzi T, Bonsi P, Pisani A. Negative allosteric modulation of mGlu5 receptor rescues striatal D2 dopamine receptor dysfunction in rodent models of DYT1 dystonia. Neuropharmacology. 2014; 85:440-50 5. Maltese M, Martella G, Madeo G, Fagiolo I, Tassone A, Ponterio G, Sciamanna G, Burbaud P, Conn PJ, Bonsi P, Pisani A. Anticholinergic drugs rescue synaptic plasticity in DYT1 dystonia: role of M1 muscarinic receptors. Mov Disord. 2014;29(13):1655-65 6. Martella G, Maltese M, Nisticò R, Schirinzi T, Madeo G, Sciamanna G, Ponterio G, Tassone A, Mandolesi G, Vanni V, Pignatelli M, Bonsi P, Pisani A. Regional specificity of synaptic plasticity deficits in a knock-in mouse model of DYT1dystonia. Neurobiol Dis. 2014; 65:124-32 7. Vanni V, Puglisi F, Bonsi P, Ponterio G, Maltese M, Pisani A, Mandolesi G. Cerebellar synaptogenesis is compromised in mouse models of DYT1 dystonia. Exp Neurol. 2015; 271:457-67. 8. Sciamanna G, Ponterio G, Mandolesi G, Bonsi P, Pisani A. Optogenetic stimulation reveals distinct modulatory properties of thalamostriatal vs corticostriatal glutamatergic inputs to fast-spiking interneurons. Sci Rep. 2015; 5:16742 9. Sciamanna G, Napolitano F, Pelosi B, Bonsi P, Vitucci D, Nuzzo T, Punzo D, Ghiglieri V, Ponterio G, Pasqualetti M, Pisani A, Usiello A. Rhes regulates dopamine D2 receptor transmission in striatal cholinergic interneurons. Neurobiol Dis. 2015; 78:146-61 10. Maltese M, Martella G, Imbriani P, Schuermans J, Billion K, Sciamanna G, Farook F, Ponterio G, Tassone A, Santoro M, Bonsi P, Pisani A, Goodchild RE. Abnormal striatal plasticity in a DYT11/SGCE myoclonus dystonia mouse model is reversed by adenosine A2A receptor inhibition. Neurobiol Dis. 2017; 108:128-139. 11. Maltese M, Stanic J, Tassone A, Sciamanna G, Ponterio G, Vanni V, Martella G, Imbriani P, Bonsi P, Mercuri NB, Gardoni F, Pisani A. Early structural and functional plasticity alterations in a susceptibility period of DYT1 dystonia mouse striatum. Elife. 2018;7: e33331. 12. Ponterio G, Tassone A, Sciamanna G, Vanni V, Meringolo M, Santoro M, Mercuri NB, Bonsi P, Pisani A. Enhanced mu opioid receptor-dependent opioidergic modulation of striatal cholinergic transmission in DYT1 dystonia. Mov Disord.2018;33(2):310-320 13. Meringolo M, Tassone A, Imbriani P, Ponterio G, Pisani A. Dystonia: Are animal models relevant in therapeutics? Rev Neurol (Paris). 2018;174(9):608-614 14. Bonsi P, Ponterio G, Vanni V, Tassone A, Sciamanna G, Migliarini S, Martella G, Meringolo M, Dehay B, Doudnikoff E, Zachariou V, Goodchild RE, Mercuri NB,D'Amelio M, Pasqualetti M, Bezard E, Pisani A. RGS9-2 rescues dopamine D2 receptor levels and signaling in DYT1 dystonia mouse models. EMBO Mol Med. 2019;11(1): e9283 15. Imbriani P, Tassone A, Meringolo M, Ponterio G, Madeo G, Pisani A, Bonsi P,Martella G. Loss of Non-Apoptotic Role of Caspase-3 in the PINK1 Mouse Model of Parkinson's Disease. Int J Mol Sci. 2019; 20(14):3407 16. Imbriani P, Ponterio G, Tassone A, Sciamanna G, El Atiallah I, Bonsi P, Pisani A. Models of dystonia: an update. J Neurosci Methods. 2020, 1;339:108728 17. Yu-Taeger L, Ott T, Bonsi P, Tomczak C, Wassouf Z, Martella G, Sciamanna G, Imbriani P, Ponterio G, Tassone A, Schulze-Hentrich JM, Goodchild R, Riess O, Pisani A, Grundmann-Hauser K, Nguyen HP. Impaired dopamine- and adenosine-mediated signaling and plasticity in a novel rodent model for DYT25 dystonia. Neurobiol Dis. 2020; 134:104634 18. Sciamanna G, Ponterio G, Vanni V, Laricchiuta D, Martella G, Bonsi P, Meringolo M, Tassone A, Mercuri NB, Pisani A. Optogenetic Activation of Striatopallidal Neurons Reveals Altered HCN Gating in DYT1 Dystonia. Cell Rep. 2020, 19;31(7):107644. 19. Tassone A, Martella G, Meringolo M, Vanni V, Sciamanna G, Ponterio G, Imbriani P, Bonsi P, Pisani A. Vesicular Acetylcholine Transporter Alters Cholinergic Tone and Synaptic Plasticity in DYT1 Dystonia. Mov Disord. 2021;36(12):2768-2779 20. Cheng F, Zheng W, Barbuti PA, Bonsi P, Liu C, Casadei N, Ponterio G, Meringolo M, Admard J, Dording CM, Yu-Taeger L, Nguyen HP, Grundmann-Hauser K, Ott T, Houlden H, Pisani A, Krüger R, Riess O. DYT6 mutated THAP1 is a cell type dependent regulator of the SP1 family. Brain. 2022: awac001. 21. Bonsi P, Cuomo D, Martella G, Madeo G, Schirinzi T, Puglisi F, Ponterio G, Pisani A. Centrality of striatal cholinergic transmission in Basal Ganglia function. Front Neuroanat. 2011; 5:6. 22. Sciamanna G, Tassone A, Martella G, Mandolesi G, Puglisi F, Cuomo D, Madeo G, Ponterio G, Standaert DG, Bonsi P, Pisani A. Developmental profile of the aberrant dopamine D2 receptor response in striatal cholinergic interneurons in DYT1 dystonia. PLoS One. 2011;6(9): e24261 23. Tassone A, Madeo G, Schirinzi T, Vita D, Puglisi F, Ponterio G, Borsini F, Pisani A, Bonsi P. Activation of 5-HT6 receptors inhibits corticostriatal glutamatergic transmission. Neuropharmacology. 2011;61(4):632-7 24. Ponterio G, Schirinzi T, Alemseged F, Maltese M, Pisani A. How relevant is the cholinergic system in DYT1 dystonia? Basal Ganglia Book; 2012, Vol 2: 227-230 25. Madeo G, Martella G, Schirinzi T, Ponterio G, Shen J, Bonsi P, Pisani A. Aberrant striatal synaptic plasticity in monogenic parkinsonisms. Neuroscience. 2012; 211:126-35 26. Sciamanna G, Tassone A, Mandolesi G, Puglisi F, Ponterio G, Martella G, Madeo G, Bernardi G, Standaert DG, Bonsi P, Pisani A. Cholinergic dysfunction alters synaptic integration between thalamostriatal and corticostriatal inputs in DYT1dystonia. J Neurosci. 2012;32(35):11991-2004 27. Puglisi F, Vanni V, Ponterio G, Tassone A, Sciamanna G, Bonsi P, Pisani A, Mandolesi G. Torsin A Localization in the Mouse Cerebellar Synaptic Circuitry. PLoS One. 2013;8(6): e68063 28. Ponterio G, Tassone A, Sciamanna G, Riahi E, Vanni V, Bonsi P, Pisani A. Powerful inhibitory action of mu opioid receptors (MOR) on cholinergic interneuron excitability in the dorsal striatum. Neuropharmacology. 2013; 75:78-85 Personal skills and competences Mother tongue: Italian English language: Understanding reading C1, understanding listening B2, spoken production and interaction B2, Writing C1. • Windows operating system, Microsoft Office (Word, Power Point, Excel), Corel Draw, Adobe Photoshop, Adobe Reader, Prism Graph Pad, Image J, Gpower • Driving licence B • Boat licence (12 miles) In compliance with the Italian legislative Decree no. 196 dated 30/06/2003 and Regolamento UE 2016/679, I hereby authorize you to use and process my personal details contained in this document.