Paganelli Roberto

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WORK EXPERIENCE 1-11-2022 – presesnt ADJUNCT PROFESSOR, INTERNAL MEDICINE, SAINT CAMILLUS INTERNATIONAL UNIVERSITY OF HEALTH AND MEDICAL SCIENCES, ROME Teaching 2 Credits for the 3rd Year 1st semester Course of Clinical Semeiotics, School of Medicine, for two courses. 1-1-2021 – present ACADEMIC EDITOR, PATHOGENS, SECTION OF VACCINES AND IMMUNOTHERAPY, MDPI (from 1-1-2023 also serving for BIOMEDICINES, MDPI). 1-11-2004 – 1-11-2021 FULL PROFESSOR, INTERNAL MEDICINE, UNIVERSITA’ G. D’ANNUNZIO CHIETI-PESCARA -Board Member of the Council of the Department of Medicine and Science of Aging -President of the section of Translational and Specialty Medicines -Director of the School of Specialization in Rheumatology of Chieti (2007-2014) -Director of the School of Specialization in Allergy and Clinical Immunology (2017-2021) -Coordinator of the course of Systematic Pathology 4 (2001-14) of the School of Medicine, and of the courses of Specialty Medicine and Fisiotherapy and Pathology of the musculoskeletal system of the Schook of Fisiotherapy (2005-2021), Abdominal organs and Systemic Diseases of the School of Dieticians (2006-2021), Emergency Medicine of the School of Nursing sciences (2020-21), -Teaching commitment for the subjects Rheumatology, Clinical Immunology, Emergency Medicine and Clinical Semeiotics, and also lessons for the Schools of Specialization of Internal Medicine, Emergency Medicine, Geriatrics, Dermatology, Infectious Diseases, Physical Medicine and Rehabilitation, Allergy and Clinical Immunology, Occupational Medicine,,,,,, Radiology and Tadiotherapy. - 1-12-1999 – 31-10-2004 ASSOCIATE PROFESSOR OF INTERNAL MEDICINE, UNIVERSITA’ G. D’ANNUNZIO, CHIETI- PESCARA Board Member of the Council of the Department of Medicine and Science of Aging Teacher of the disciplines Diseases of the Immune System, Rheumatology, in the Course for Medical Degree, and in the Courses for Fisiotherapist, Dieticians, Movement sciences, Cardiocirculatory Technician, Biomedical Laboratory Technician, Preventive Medicine Technician. 1-12-1984 – 30-11-1999 ASSISTANT PROFESSOR (TENURE) – UNIVERSITA’ LA SAPIENZA, ROME Physician in charge of the Outpatients' Clinic (Allergy section) and Day Hospital Clinical Assistant(1989-1994) of the Department of Allergy and Clinical Immunology, Policlinico Umberto I of Rome University Teacher at the Postgraduate School of Allergy and Clinical Immunology, and the Diploma Course for Laboratory Technician.. 1983 – 30-11-1984 ASSISTANT PROFESSOR, UNIVERSITA’ DEGLI STUDI DE L’AQUILA Starting 1-06-1984, at San Salvatore Hospital, Internal Medicine, L'Aquila 1982-83 Consultant for the Medical Direction, Istituto farmacologico C. Serono, Roma 1-2-1978 – March 1982 Scholarship of the Ministry for Foreign Affairs (1978), Nuffield Foundation Scholarship (1979-82) as Research Fellow at the Department of Immunology, Institute of Child Health, University of London. H. Clin. Assistant Great Ormond Street Hospital, London (1979-82). SCHOOLING JUNE 1984 SPECIALIZATION IN ALLERGY AND CLINICAL IMMUNOLOGY, UNIVERSITA’ LA SAPIENZA, ROME 70/70 with honors JULY 1976 MEDICAL DEGREE, UNIVERSITA’ LA SAPIENZA, ROME 110/110 with honors JULY 1970 High School Diploma (Maturità Classica, Liceo Giulio Cesare), Rome 60/60 with honors SKILLS AND QUALIFICATIONS • Written and spoken English language • Cambridge University Lower Certificate of English at age 16 (1967) • Work experience abroad: from Feb, 1978 to March 1982 at the Dept. of Immunology, I.C.H. University of London (UK) • Sabbatical at the Miller School of Medicine, University of Miami (FL) in 2017 • Teaching member of the Research Doctorate in Life Sciences and Translational Medicine, at the University "G. d'Annunzio" • Tutor and thesis supervisor of 3 Ph.D. students (one from U.S.), in collaboration with the Dept. of Rheumatology, University College Hospital, London, and the Dept. of Microbiology and Immunology, University of Miami. • Thesis Supervisor of >100 students for the Degree in Medicine and Surgery and for Specializations in Rheumatology and Allergy and Clinical Immunology OTHER ACTIVITIES Board Member of the European Society for Immuno Deficiencies (ESID) in the Committee on Clinical Immunology, in charge for establishing the European Primary Immunodeficiency Registry; in the European Academy of Allergy and Clinical Immunology member of the Subcommittee on adverse reactions to foods; Member of the Council of tje Società Italiana di Allergologia, Asma ed Immunologia Clinica (SIAAIC) from 1989 tp 1994 and from 2008 to 2016; member of the Committee on Adverse Drug reactions, and president of the Interest group on Primary and secondary immunodeficiencies Member of the Committee on Immune deficiencies of the World Allergy organization WAO (2014-) Consultant in Immunology at IRCCS San Gallicano, I.F.O. - Polo Dermatologico, Rome, from june 2000 to 2002. Member of the Steering Committee of the Center of Excellence on Ageing of The Ud'A Foundation in Chieti recognized by the Italian Ministry of University, and Director of the Unit of Biogerontology and Cytokines of the Centro di Eccellenza sull'Invecchiamento (CESI) from 2003 to 2017. Member of the Ethical Committee of the College of Internal Medicine COLMED-09) Member of the Board of the Section Lazio-Abruzzo of the SIAAIC since 2016-. Past member of the Scientific Committees of the Associazione Nazionale per la Lotta all'AIDS (ANLAIDS), Lega italiana Sclerosi sistemica and the Gruppo LES italiano lupus-italy. Member of the Strategic Committee on Primary Immunodeficiencies in the A.I.E.O.P. and participant to the Italian Network I.P.I.Net; Co-founder and Member of the Research group Stem-Tech (Stem cell studies) of the Universities “G. D’Annunzio” of Chieti and University of Teramo. SCIENTIFIC SOCIETIES, GRANTS MEMBER: SOCIETÀ ITALIANA DI IMMUNOLOGIA, IMMUNOLOGIA CLINICA E ALLERGOLOGIA (SIICA), SOCIETÀ ITALIANA DI ALLERGOLOGIA, ASMA E IMMUNOLOGIA CLINICA (SIAAIC), COLLEGIO DEI DOCENTI DI MEDICINA INTERNA (COLMED09), WORLD ALLERGY ORGANIZATION (WAO). PAST MEMBERSHIPS: EUROPEAN ACADEMY OF ALLERGY AND CLINICAL IMMUNOLOGY (EAACI), EUROPEAN SOCIETY FOR IMMUNE DEFICIENCIES (ESID), BRITISH SOCIETY OF IMMUNOLOGY(BSI), AMERICAN ACADEMY FOR THE ADVANCEMENT OF SCIENCES (AAAS), FEDERATION OF CLINICAL IMMUNOLOGY SOCIETIES (FOCIS), SOCIETÀ ITALIANA DI MEDICINA INTERNA (SIMI), AMERICAN ASSOCIATION OF IMMUNOLOGY (AAI). Research grants in Italy (Fondi Progetti dii interesse nazionale, MIUR; Progetto FAT.MA: CNR; Fondi Progetti di ricerca sull’Aids, Ministero della Salute) and internazional funding (EU Projects BioMed 1, and 5th Framework Project; Thematic Network ImAginE), SCIENTIFIC INTERESTS ALLERGIC DISEASES and in particular the study of food allergies, their pathogenic mechanisms and the role of intestinal permeabiliy, oral antigen administration and the mucosal immune response; regulation of IgE production, and the role of cytokines (IL4, IFN alpha and gamma). PRIMARY IMMUNODEFICIENCIES and in particular the defects of humoral immunity, common variable immunodeficiency, IgA deficiency, IgG subclass defects, ataxia-telangectasia; T cell defects and SCID, and the hyper-IgE syndrome; studies of pathogenic mechanisms, molecular defects, diagnosis and therapy with i.v. immunoglobulins. HIV INFECTION and other viral infections (HBV, HCV,Flu vaccination, EBV, CMV) in particular the immune response and the host-virus relationship, correlates of susceptibility and resistance to infection, and the response to therapy (HAART in HIV, and cohort studies as Long term non progressors). IMMUNOSENESCENCE in particular changes in T lymphocyte subsets in ageing, proinflammatory cytokines production both in health and in age associated degenerative and inflammatory disorders, including neurodegeneration. IMMUNOPATHOGENIC MECHANISMS in particular studies of antibody synthesis, IgE and IgG subclasses production, and circulating immune complexes. More recently, studies of MESENCHYMAL (STROMAL) STEM CELLS from different organs, the regulation of autoantibody formation in autoimmune diseases and the cross-talk of the immune and adipose systems. EDITORIAL ACTIVITY AND PUBLICATIONS Author or coauthor of 400 published papers (articles, reviews, book chapters, conference proceedings, etc.) 75% in English. EDITOR IN CHIEF OF THE SECTION VACCINES AND THERAPEUTIC DEVELOPMENTS OF THE JOURNAL Pathogens (I.F.3,7) , Associate Editor Section Translational Pharmacology in FRONTiERS IN PHARMACOLOGY (I.F. 5,6), Editor IMMUNITY AND AGEING (I.F.9.7), Academic Editor BIOMEDICINE (I.F.4.7), Editor AUTOIMMUNITY AND AUTOINFLAMMATORY DISORDERS Section in FRONTIERS IN IMMUNOLOGY (I.F. 7.3)- also on Editorial Board of INNOSC Theranostics and Pharmacological Sciences, Exploration in Immunology, Journal of Inflammatory Diseases. Reviewer for several journals of top 5 scientific publishers. Invited speaker at several National and International Meetings, presenter of more than 250 abstracts as oral or poster presentations; invited to present Seminars at several Scientific associations and Universities in three Continents. Served as Chair and Panelist in the same Scientific meetings. LIST OF PUBLICATIONS Latest book chapter: Federica Pulvirenti, Emma de Maio, Cinzia Milito, Roberto Paganelli, Isabella Quinti Chapter 48 – Asplenia. In: Editor(s): Kathleen E. Sullivan, E. Richard Stiehm, Stiehm's Immune Deficiencies (Second Edition), Academic Press, 2020, Pages 1021-1033, https://doi.org/10.1016/B978-0-12-816768-7.00048-X. ARTICLES IN PUBMED Luzi G, Pandolfi F, Paganelli R, Aiuti F. Aspetti immunologici della rettocolite ulcerosa [Immunological aspects of ulcerative rectocolitis]. Recenti Prog Med. 1977 Sep;63(3):213-27. Paganelli R, Ramadas D, Layward L, Harvey BA, Soothill JF. Maternal smoking and cord blood immunity function. Clin Exp Immunol. 1979 May;36(2):256-9. Pandolfi F, Paganelli R, Sirianni MC, D'Amelio R, Aiuti F. Rosette formation with mouse erythrocytes by lymphocytes from normal donors and patients with various diseases. Z Immunitatsforsch Immunobiol. 1979 Jun;155(5):378-86. Paganelli R, Levinsky RJ, Brostoff J, Wraith DG. Immune complexes containing food proteins in normal and atopic subjects after oral challenge and effect of sodium cromoglycate on antigen absorption. Lancet. 1979 Jun 16;1(8129):1270-2. Pandolfi F, Paganelli R, Ragona G, Quinti I, Aiuti F. Mouse rosette forming cells and surface immunoglobulins in human lymphoid cells. Boll Ist Sieroter Milan. 1979 Nov 30;58(5):423-8. Paganelli R, Levinsky RJ. Solid phase radioimmunoassay for detection of circulating food protein antigens in human serum. J Immunol Methods. 1980;37(3-4):333-41. doi: 10.1016/0022-1759(80)90319-1. Paganelli R, Ngu JL, Levinsky RJ. Circulating immune complexes in onchocerciasis. Clin Exp Immunol. 1980 Mar;39(3):570-5. Paganelli R, Soothill JF, Marshall WC, Hamblin AS. Transfer factor and cytomegalovirus viruria. Lancet. 1981 Jan 31;1(8214):273-4. Paganelli R. Ruolo fisio-patologico dell'assorbimento intestinale di antigeni alimentari. Recenti Prog Med. 1981 May;70(5):487-93. Roberts SA, Reinhardt MC, Paganelli R, Levinsky RJ. Specific antigen exclusion and non-specific facilitation of antigen entry across the gut in rats allergic to food proteins. Clin Exp Immunol. 1981 Jul;45(1):131-6. Paganelli R, Levinsky RJ, Atherton DJ. Detection of specific antigen within circulating immune complexes: validation of the assay and its application to food antigen-antibody complexes formed in healthy and food-allergic subjects. Clin Exp Immunol. 1981 Oct;46(1):44-53. Paganelli R, Levinsky RJ. Differences in specific antibody responses of human tonsillar cells to an oral and a parenteral antigen. Scand J Immunol. 1981 Oct;14(4):353-8. Paganelli R. Spontaneous suppressor cells for mitogen responsiveness of cord blood lymphocytes. Clin Immunol Immunopathol. 1981 Dec;21(3):295-300. Roberton DM, Paganelli R, Dinwiddie R, Levinsky RJ. Milk antigen absorption in the preterm and term neonate. Arch Dis Child. 1982 May;57(5):369-72. Businco L, Rossi P, Paganelli R, Seminara R, Aiuti F. Immunologic reconstitution with bone marrow transplantation and thymic hormones in two patients with severe pure T-cell defects. Birth Defects Orig Artic Ser. 1983;19(3):281-5. Turner MW, Paganelli R, Levinsky RJ, Williams A. Antigen-binding radioimmunoassays for human IgG antibodies to bovine beta-lactoglobulin. J Immunol Methods. 1983 Jan 28;56(2):175-83. Aiuti F, Sirianni MC, Paganelli R, Stella A, Turbessi G, Fiorilli M. A placebo-controlled trial of thymic hormone treatment of recurrent herpes simplex labialis infection in immunodeficient hosts. Int J Clin Pharmacol Ther Toxicol. 1983 Feb;21(2):81-6. Paganelli R, Aiuti F, Beverley PC, Levinsky RJ. Impaired production of interleukins in patients with cell-mediated immunodeficiencies. Clin Exp Immunol. 1983 Feb;51(2):338-44. Paganelli R, Atherton DJ, Levinsky RJ. Differences between normal and milk allergic subjects in their immune responses after milk ingestion. Arch Dis Child. 1983 Mar;58(3):201-6. 20: Fiorilli M, Businco L, Pandolfi F, Paganelli R, Russo G, Aiuti F. Heterogeneity of immunological abnormalities in ataxia-telangiectasia. J Clin Immunol. 1983 Apr;3(2):135-41. Aiuti F, Paganelli R. Food allergy and gastrointestinal diseases. Ann Allergy. 1983 Aug;51(2 Pt 2):275-80. Reinhardt MC, Paganelli R, Levinsky RJ. Intestinal antigen handling at mucosal surfaces in health and disease: human and experimental studies. Ann Allergy. 1983 Aug;51(2 Pt 2):311-4. Aiuti F, Sirianni MC, Fiorilli M, Paganelli R, Stella A, Turbessi G. A placebo-controlled trial of thymic hormone treatment of recurrent herpes simplex labialis infection in immunodeficient host: results after a 1-year follow-up. Clin Immunol Immunopathol. 1984 Jan;30(1):11-8. Paganelli R, Matricardi PM, Aiuti F. Interactions of food antigens, antibodies, and antigen-antibody complexes in health and disease. Clin Rev Allergy. 1984 Feb;2(1):69-78. Matricardi PM, Capobianchi MR, Paganelli R, Facchini J, Sirianni MC, Seminara R, Dianzani F, Aiuti F. Interferon production in primary immunodeficiencies. J Clin Immunol. 1984 Sep;4(5):388-94. Paganelli R, Capobianchi MR, Matricardi PM, Cioè L, Seminara R, Dianzani F, Aiuti F. Defective interferon-gamma production in ataxia-telangiectasia. Clin Immunol Immunopathol. 1984 Sep;32(3):387-91. Businco L, Rossi P, Paganelli R, Galli E, DiGilio G, Lulli P, Aiuti F. Bone marrow transplantation and thymopoietin pentapeptide treatment in two infants with immunodeficiency with predominant T-cell defects. Clin Immunol Immunopathol. 1984 Oct;33(1):123-30. D'Amelio R, Fattorossi A, Berti R, Rossi P, Paganelli R, Castagliuolo PP. Serum IgG, IgA, IgM, IgE, salivary IgA levels and lung function in a healthy male population from the Italian Air Force: a preliminary study. Ann Allergy. 1984 Nov;53(5):432-5. Paganelli R, Pallone F, Montano S, Le Moli S, Matricardi PM, Fais S, Paoluzi P, D'Amelio R, Aiuti F. Isotypic analysis of antibody response to a food antigen in inflammatory bowel disease. Int Arch Allergy Appl Immunol. 1985;78(1):81-5. Le Moli S, Paganelli R, Sirianni MC, Nisini R, Quinti I, Seminara R, D'Amelio R, Aiuti F. Gli effetti in vitro del lisozima su alcune funzioni specifiche e non specifiche del sistema immunitario. Boll Ist Sieroter Milan. 1986;65(4):283-9. Paganelli R, Quinti I, D'Offizi GP, Papetti C, Cabello A, Aiuti F. A study of IgE in immunoglobulin preparations for intravenous administration. I. IgE in intravenous IgG. Vox Sang. 1986;51(2):87-91. Fiorilli M, Russo G, Paganelli R, Papetti C, Carbonari M, Crescenzi M, Calvani M, Quinti I, Aiuti F. Hypogammaglobulinemia with hyper-IgM, severe T-cell defect, and abnormal recirculation of OKT4 lymphocytes in a girl with chronic lymphadenopathy. Clin Immunol Immunopathol. 1986 Feb;38(2):256-64. Businco L, Rubaltelli FF, Paganelli R, Galli E, Ensoli B, Betti P, Aiuti F. Results in two infants with the DiGeorge syndrome--effects of long-term TP5. Clin Immunol Immunopathol. 1986 May;39(2):222-30. Paganelli R, Sgambato F, Carbonari M, Buono G, Bonomo R, Pontesilli O. Cow's milk hypersensitivity in an elderly woman: clinical and immunologic findings. Ann Allergy. 1986 Jun;56(6):480-3. Viganò T, Sautebin L, Magni F, Crivellari MT, Paganelli R, Galli G, Berti F, Folco G. Stimulus-related difference in the formation of leukotrienes and PGD2 after immunological and non-immunological challenge of human lung parenchyma "in vitro". Prostaglandins Leukot Med. 1986 Aug;23(2-3):109-15. doi: 10.1016/0262-1746(86)90172-1. Paganelli R, Quinti I, Carbonari M, Pontesilli O, D'Offizi GP, Letta T, Aiuti F. IgG anti-IgE in circulating immune complexes in the hyper-IgE syndrome. Clin Allergy. 1986 Nov;16(6):513-21. Paganelli R, Cavagni G, Pallone F. The role of antigenic absorption and circulating immune complexes in food allergy. Ann Allergy. 1986 Nov;57(5):330-6. Businco L, Di Fazio A, Ziruolo MG, Boner AL, Valletta EA, Ruco LP, Vitolo D, Ensoli B, Paganelli R. Clinical and immunological findings in four infants with Omenn's syndrome: a form of severe combined immunodeficiency with phenotypically normal T cells, elevated IgE, and eosinophilia. Clin Immunol Immunopathol. 1987 Aug;44(2):123-33. Quinti I, Papetti C, Paganelli R, D'Amelio R, Nisini R, D'Offizi G, Aiuti F. Evaluation of the presence of RF-like activities in immunoglobulin preparations for intravenous use. I. IgG anti-IgE in intravenous Ig. J Clin Lab Immunol. 1987 Nov;24(3):135-8. 40: Paganelli R, Quinti I, D'Offizi GP, Papetti C, Carini C, Aiuti F. Immune complexes in food allergy: a critical reappraisal. Ann Allergy. 1987 Nov;59(5 Pt 2):157-61. Paganelli R, Sgambato F, D'Offizi GP, Scott JR, Rock HS, Di Nunzio D, Caporaso C, Halpern GM. IgE and IgG4 levels in allergic patients during immunotherapy. N Engl Reg Allergy Proc. 1987 Nov-Dec;8(6):393-400. Biancone L, Paganelli R, Fais S, Squarcia O, D'Offizi G, Pallone F. Peripheral and intestinal lymphocyte activation after in vitro exposure to cow's milk antigens in normal subjects and in patients with Crohn's disease. Clin Immunol Immunopathol. 1987 Dec;45(3):491-8. Quinti I, Papetti C, D'Offizi G, Cavagni G, Panchor ML, Lunardi C, Paganelli R. IgG subclasses to food antigens. Allerg Immunol (Paris). 1988 Feb;20(2):41, 43-4. Paganelli R, Capobianchi MR, Ensoli B, D'Offizi GP, Facchini J, Dianzani F, Aiuti F. Evidence that defective gamma interferon production in patients with primary immunodeficiencies is due to intrinsic incompetence of lymphocytes. Clin Exp Immunol. 1988 Apr;72(1):124-9. Paganelli R, Quinti I, D'Offizi GP, Papetti C, Nisini R, Aiuti F. Studies on the in vitro effects of auto-anti-IgE. Inhibition of total and specific serum IgE detection by a human IgG autoantibody to IgE. J Clin Lab Immunol. 1988 Jul;26(3):153-7. Cavagni G, Paganelli R, Caffarelli C, D'Offizi GP, Bertolini P, Aiuti F, Giovannelli G. Passage of food antigens into circulation of breast-fed infants with atopic dermatitis. Ann Allergy. 1988 Nov;61(5):361-5. Fagiolo U, Paganelli R, Ossi E, Quinti I, Cancian M, D'Offizi GP, Fiocco U. Intestinal permeability and antigen absorption in rheumatoid arthritis. Effects of acetylsalicylic acid and sodium chromoglycate. Int Arch Allergy Appl Immunol. 1989;89(1):98-102. Paganelli R, Capobianchi MR, D'Offizi GP, Mezzaroma I, Cherchi M, Di Marco P, Dianzani F, Aiuti F. Alpha interferon treatment in HIV infected patients restores gamma interferon production in vitro. Boll Ist Sieroter Milan. 1989;68(1):67-71. Quinti I, Paganelli R, Marone G, Aiuti F. IgG anti IgE in atopic dermatitis. Acta Derm Venereol Suppl (Stockh). 1989;144:67-9. Paganelli R, Scala E, Guerra E, Quinti I. Role of immune complexes in atopic dermatitis. Allergy. 1989;44 Suppl 9:65-9. Paganelli R, Quinti I. Pathological significance of circulating IgG anti-IgE complexes. Monogr Allergy. 1989;26:184-97. Quinti I, Paganelli R, Scala E, Guerra E, Aiuti F. Humoral response to food antigens. Allergy. 1989;44 Suppl 9:59-64. Cossarizza A, Monti D, Bersani F, Paganelli R, Montagnani G, Cadossi R, Cantini M, Franceschi C. Extremely low frequency pulsed electromagnetic fields increase interleukin-2 (IL-2) utilization and IL-2 receptor expression in mitogen-stimulated human lymphocytes from old subjects. FEBS Lett. 1989 May 8;248(1-2):141-4. Marone G, Casolaro V, Paganelli R, Quinti I. IgG anti-IgE from atopic dermatitis induces mediator release from basophils and mast cells. J Invest Dermatol. 1989 Aug;93(2):246-52. Carbonari M, Cherchi M, Paganelli R, Giannini G, Galli E, Gaetano C, Papetti C, Fiorilli M. Relative increase of T cells expressing the gamma/delta rather than the alpha/beta receptor in ataxia-telangiectasia. N Engl J Med. 1990 Jan 11;322(2):73-6. Paganelli R, Fagiolo U, Cancian M, Sturniolo GC, Scala E, D'Offizi GP. Intestinal permeability in irritable bowel syndrome. Effect of diet and sodium cromoglycate administration. Ann Allergy. 1990 Apr;64(4):377-80. De Santis A, Paganelli R, Stefanoni R, Di Sabatino A, Angelico M. Prevalence of gallstones in patients with primary immunoglobulin deficiency. Evidence for lack of association. Dig Dis Sci. 1990 Jun;35(6):716-20. Quinti I, Paganelli R, Scala E, Guerra E, Mezzaroma I, D'Offizi GP, Aiuti F. Hepatitis C virus antibodies in gammaglobulin. Lancet. 1990 Dec 1;336(8727):1377. Paganelli R, Fanales-Belasio E, Carmini D, Scala E, Meglio P, Businco L, Aiuti F. Serum eosinophil cationic protein in patients with atopic dermatitis. Int Arch Allergy Appl Immunol. 1991;96(2):175-8. 60: Paganelli R, Fagiolo U, Cancian M, Scala E. Intestinal permeability in patients with chronic urticaria-angioedema with and without arthralgia. Ann Allergy. 1991 Feb;66(2):181-4. Biancone L, Boirivant M, Fais S, Ricci GL, Paganelli R, Pallone F. Serum immunomodulatory factors in gastrointestinal diseases. A 30-50-kD serum fraction in Crohn's disease capable of modulating lymphocyte activation. Clin Exp Immunol. 1991 Mar;83(3):401-6. Cossarizza A, Ortolani C, Forti E, Montagnani G, Paganelli R, Zannotti M, Marini M, Monti D, Franceschi C. Age-related expansion of functionally inefficient cells with markers of natural killer activity in Down's syndrome. Blood. 1991 Mar 15;77(6):1263-70. Paganelli R, Scala E, Capobianchi MR, Fanales-Belasio E, D'Offizi G, Fiorilli M, Aiuti F. Selective deficiency of interferon-gamma production in the hyper-IgE syndrome. Relationship to in vitro IgE synthesis. Clin Exp Immunol. 1991 Apr;84(1):28-33. Paganelli R, Quinti I, di Sabatino A, d'Offizi GP, Scala E, Meglio P, Aiuti F. Topical flunisolide treatment of perennial rhinitis: clinical and immunological effects. Allergol Immunopathol (Madr). 1991 Sep-Oct;19(5):194-6. Mezzaroma I, Avella A, Paganelli R, Ensoli B, d'Offizi G, Sirianni MC, Luzi G, Valdarchi C, Aiuti F. Recombinant alpha-2a interferon treatment in patients with acquired immunodeficiency syndrome (AIDS) and AIDS-related complex (ARC): clinical and immunological evaluation. Allergol Immunopathol (Madr). 1991 Sep- Oct;19(5):201-7. Paganelli R, Fanales-Belasio E, Scala E, Carmini D, Mezzaroma I, Pinter E, Aiuti F. Serum eosinophil cationic protein (ECP) in human immunodeficiency virus (HIV) infection. J Allergy Clin Immunol. 1991 Sep;88(3 Pt 1):416-8. Paganelli R, Fanales-Belasio E, Samolewska M. New perspectives on the screening of food allergy. Allerg Immunol (Paris). 1991 Dec;23(10):436-7. Paganelli R, Scala E, Scarselli E, Ortolani C, Cossarizza A, Carmini D, Aiuti F, Fiorilli M. Selective deficiency of CD4+/CD45RA+ lymphocytes in patients with ataxia-telangiectasia. J Clin Immunol. 1992 Mar;12(2):84-91. Capobianchi MR, Ankel H, Ameglio F, Paganelli R, Pizzoli PM, Dianzani F. Recombinant glycoprotein 120 of human immunodeficiency virus is a potent interferon inducer. AIDS Res Hum Retroviruses. 1992 May;8(5):575-9. Paganelli R, Quinti I, di Sabatino A, d'Offizi GP, Scala E, Meglio P, Aiuti F. Topical flunisolide treatment of perennial rhinitis: clinical and immunological effects. Allergol Immunopathol (Madr). 1992 May-Jun;20(3):124-6. Cantani A, Paganelli R, Meglio P, Ferrara M, Fameles-Belasio E, Businco L. Effect of flunisolide on nasal eosinophils and IgE, and symptom score in children with allergic rhinitis. J Investig Allergol Clin Immunol. 1992 Jul- Aug;2(4):181-6. Paganelli R, Quinti I, Fagiolo U, Cossarizza A, Ortolani C, Guerra E, Sansoni P, Pucillo LP, Scala E, Cozzi E, et al. Changes in circulating B cells and immunoglobulin classes and subclasses in a healthy aged population. Clin Exp Immunol. 1992 Nov;90(2):351-4. Fagiolo U, Cossarizza A, Santacaterina S, Ortolani C, Monti D, Paganelli R, Franceschi C. Increased cytokine production by peripheral blood mononuclear cells from healthy elderly people. Ann N Y Acad Sci. 1992 Nov 21;663:490-3. Paganelli R, Scala E, Ansotegui IJ, Mezzaroma I, Pinter E, Ferrara R, D'Offizi GP, Aiuti F. Hyper IgE syndrome induced by HIV infection. Immunodeficiency. 1993;4(1-4):149-52. Pandolfi F, Paganelli R, Cafaro A, Oliva A, Giovannetti A, Scala E, Quinti I, Aiuti F. Abnormalities of lymphocyte subpopulations in CVI do not correlate with increased production of IL-6. Immunodeficiency. 1993;4(1-4):19-23. Pandolfi F, Paganelli R, Oliva A, Quinti I, Polidori V, Fanales-Belasio E, Guerra E, Aiuti F. Increased IL-6 gene expression and production in patients with common variable immunodeficiency. Clin Exp Immunol. 1993 May;92(2):239-44. Fagiolo U, Cossarizza A, Scala E, Fanales-Belasio E, Ortolani C, Cozzi E, Monti D, Franceschi C, Paganelli R. Increased cytokine production in mononuclear cells of healthy elderly people. Eur J Immunol. 1993 Sep;23(9):2375-8. Fagiolo U, Amadori A, Biselli R, Paganelli R, Nisini R, Cozzi E, Zamarchi R, D'Amelio R. Quantitative and qualitative analysis of anti-tetanus toxoid antibody response in the elderly. Humoral immune response enhancement by thymostimulin. Vaccine. 1993 Oct;11(13):1336-40. Quinti I, Sacco G, el Salman D, Paganelli R, Fiorilli M, Aiuti F, Pandolfi F. Infection with hepatitis C virus. Intravenous gammaglobulin may still infect patients. BMJ. 1994 Mar 26;308(6932):856. 80: Paganelli R, Cherchi M, Scala E, Maggi E, Carbonari M, Ferranti G, Dell'Anna L, Pachì A, Fiorilli M. Activated and "memory" phenotype of circulating T lymphocytes in intrauterine life. Cell Immunol. 1994 May;155(2):486-92. Paganelli R, Scala E, Quinti I, Ansotegui IJ. Humoral immunity in aging. Aging (Milano). 1994 Jun;6(3):143-50. Vorechovský I, Koskinen S, Paganelli R, Smith CI, Busslinger M, Hammarström L. The PAX5 gene: a linkage and mutation analysis in candidate human primary immunodeficiencies. Immunogenetics. 1995;42(2):149-52. Biselli R, Fagiolo U, Nisini R, Paganelli R, D'Offizi G, Ferrara R, Bertollo L, D'Amelio R. Humoral response to influenza hemagglutinin: oligoclonal spectrotype and failure of thymopentin as immunoadjuvant. Gerontology. 1995;41(1):3-10. Paganelli R, Scala E, Ansotegui IJ, Ausiello CM, Halapi E, Fanales-Belasio E, D'Offizi G, Mezzaroma I, Pandolfi F, Fiorilli M, Cassone A, Aiuti F. CD8+ T lymphocytes provide helper activity for IgE synthesis in human immunodeficiency virus-infected patients with hyper-IgE. J Exp Med. 1995 Jan 1;181(1):423-8. Paganelli R, Scala E, Mezzaroma I, Pinter E, D'Offizi G, Fanales-Belasio E, Rosso RM, Ansotegui IJ, Pandolfi F, Aiuti F. Immunologic aspects of hyperimmunoglobulinemia E-like syndrome in patients with AIDS. J Allergy Clin Immunol. 1995 May;95(5 Pt 1):995-1003. Scala E, Bellioni B, Guerra EC, Aiuti F, Paganelli R. CD8+CD45RA+ in HIV- infected patients are predominantly CD11abright. AIDS. 1995 Jun;9(6):653-4. D'Offizi G, Ferrara R, Donati P, Bellomo P, Paganelli R. Angiolymphoid hyperplasia with eosinophils in HIV infection. AIDS. 1995 Jul;9(7):813-4. Oliva A, Quinti I, Scala E, Fanales-Belasio E, Rainaldi L, Pierdominici M, Giovannetti A, Paganelli R, Aiuti F, Pandolfi F. Immunodeficiency with hyperimmunoglobulinemia M in two female patients is not associated with abnormalities of CD40 or CD40 ligand expression. J Allergy Clin Immunol. 1995 Sep;96(3):403-10. Fanales-Belasio E, Ciofalo A, Zambetti G, Ansotegui IJ, Scala E, Paganelli R, Filiaci F. Intranasal immunotherapy with Dermatophagoides extract: in vivo and in vitro results of a double-blind placebo-controlled trial. Rhinology. 1995 Sep;33(3):126-31. Quinti I, Pandolfi F, Paganelli R, el Salman D, Giovannetti A, Rosso R, Oliva A, Rainaldi L, Aiuti F. HCV infection in patients with primary defects of immunoglobulin production. Clin Exp Immunol. 1995 Oct;102(1):11-6. Vorechovský I, Zetterquist H, Paganelli R, Koskinen S, Webster AD, Björkander J, Smith CI, Hammarström L. Family and linkage study of selective IgA deficiency and common variable immunodeficiency. Clin Immunol Immunopathol. 1995 Nov;77(2):185-92. Scala E, Ansotegui IJ, Bellioni B, Guerra EC, Aiuti F, Paganelli R. Expansion of CD11abright cells in CD8+CD45RA+ from HIV-infected patients: a new early marker for disease progression? AIDS Res Hum Retroviruses. 1995 Nov;11(11):1327-33. Ansotegui IJ, Errigo E, Bellegrandi S, Paganelli R. Treatment of food allergy with low-dose vaccination. Monogr Allergy. 1996;32:241-5. Paganelli R, Scala E, Di Gioacchino M, Bellioni B, Stefanini GF. Prophylaxis and treatment of food allergy with disodium cromoglycate. Monogr Allergy. 1996;32:246-52. Quinti I, Pandolfi F, Paganelli R, Giovannetti A, Sacco G, Oliva A, Aiuti F. Hepatitis C virus infection in Italian patients with hypogammaglobulinemia. Clin Ther. 1996;18 Suppl B:96-107. Cossarizza A, Ortolani C, Paganelli R, Barbieri D, Monti D, Sansoni P, Fagiolo U, Castellani G, Bersani F, Londei M, Franceschi C. CD45 isoforms expression on CD4+ and CD8+ T cells throughout life, from newborns to centenarians: implications for T cell memory. Mech Ageing Dev. 1996 Mar 29;86(3):173-95. Paganelli R, Scala E, Rosso R, Cossarizza A, Bertollo L, Barbieri D, Fabrizi A, Lusi EA, Fagiolo U, Franceschi C. A shift to Th0 cytokine production by CD4+ cells in human longevity: studies on two healthy centenarians. Eur J Immunol. 1996 Sep;26(9):2030-4. Bellegrandi S, D'Offizi G, Ansotegui IJ, Ferrara R, Scala E, Paganelli R. Propolis allergy in an HIV-positive patient. J Am Acad Dermatol. 1996 Oct;35(4):644. Quinti I, Giovannetti A, Paganelli R, Pucillo LP, Varani AR, Ricci G, Scala E, Pandolfi F, Casato M, Aiuti F. HCV infection in a patient with hyper IgM syndrome. J Clin Immunol. 1996 Nov;16(6):321-5. 100: Paganelli R, Scala E, Mazzone AM, Rosso R, Mattiacci G, Dell'Anna L, Mezzaroma I, Aiuti F. Th2-type cytokines, hypereosinophilia, and interleukin-5 in HIV disease. Allergy. 1997 Jan;52(1):110-1. Vorechovský I, Luo L, Hertz JM, Frøland SS, Klemola T, Fiorini M, Quinti I, Paganelli R, Ozsahin H, Hammarström L, Webster AD, Smith CI. Mutation pattern in the Bruton's tyrosine kinase gene in 26 unrelated patients with X-linked agammaglobulinemia. Hum Mutat. 1997;9(5):418-25. Scala E, D'Offizi G, Rosso R, Turriziani O, Ferrara R, Mazzone AM, Antonelli G, Aiuti F, Paganelli R. C-C chemokines, IL-16, and soluble antiviral factor activity are increased in cloned T cells from subjects with long-term nonprogressive HIV infection. J Immunol. 1997 May 1;158(9):4485-92. Oliva A, Scala E, Quinti I, Paganelli R, Ansotegui IJ, Giovannetti A, Pierdominici M, Aiuti F, Pandolfi F. IL-10 production and CD40L expression in patients with common variable immunodeficiency. Scand J Immunol. 1997 Jul;46(1):86-90. Romano A, Fanales-Belasio E, Di Fonso M, Giuffreda F, Palmieri V, Zeppilli P, Ansotegui IJ, Venuti A, Paganelli R, Aiuti F. Eosinophil-derived proteins in postprandial (food-dependent) exercise-induced anaphylaxis. Int Arch Allergy Immunol. 1997 Aug;113(4):505-11. Carlesimo M, Pontesilli O, Varani AR, Bernardi ML, Mazzone AM, Rosso R, Guerra EC, Cassone A, Paganelli R, Aiuti F. CD28 costimulation and T lymphocyte proliferative responses in HIV-1 infection. Clin Exp Immunol. 1997 Sep;109(3):406-11. Quinti I, el-Salman D, Monier MK, Hackbart BG, Darwish MS, el-Zamiaty D, Paganelli R, Pandolfi F, Arthur RR. HCV infection in Egyptian patients with acute hepatitis. Dig Dis Sci. 1997 Oct;42(10):2017-23. Paganelli R, Scala E, Aiuti F, Fiorilli M. B-cell help by Tc2 cells. Immunol Today. 1998 Mar;19(3):142. Scala E, Carbonari M, Del Porto P, Cibati M, Tedesco T, Mazzone AM, Paganelli R, Fiorilli M. Lymphocyte activation gene-3 (LAG-3) expression and IFN-gamma production are variably coregulated in different human T lymphocyte subpopulations. J Immunol. 1998 Jul 1;161(1):489-93. Paganelli R, Ansotegui IJ, Sastre J, Lange CE, Roovers MH, de Groot H, Lindholm NB, Ewan PW. Specific IgE antibodies in the diagnosis of atopic disease. Clinical evaluation of a new in vitro test system, UniCAP, in six European allergy clinics. Allergy. 1998 Aug;53(8):763-8. Malorni W, Rivabene R, Lucia BM, Ferrara R, Mazzone AM, Cauda R, Paganelli R. The role of oxidative imbalance in progression to AIDS: effect of the thiol supplier N-acetylcysteine. AIDS Res Hum Retroviruses. 1998 Nov 20;14(17):1589-96. Cossarizza A, Mussini C, Borghi V, Mongiardo N, Nuzzo C, Pedrazzi J, Benatti F, Moretti L, Pinti M, Paganelli R, Franceschi C, De Rienzo B. Apoptotic features of peripheral blood granulocytes and monocytes during primary, acute HIV infection. Exp Cell Res. 1999 Feb 25;247(1):304-11. Visco-Comandini U, Yun Z, Paganelli R, Orlandi P, Salotti A, Johansson B, Vahlne A, Sönnerborg A. HIV-1 nef mutations and clinical long-term nonprogression. A molecular epidemiology study. J Hum Virol. 1998 Jul- Aug;1(5):320-7. Ortolani C, Bruijnzeel-Koomen C, Bengtsson U, Bindslev-Jensen C, Björkstén B, Høst A, Ispano M, Jarish R, Madsen C, Nekam K, Paganelli R, Poulsen LK, Wüthrich B. Controversial aspects of adverse reactions to food. European Academy of Allergology and Clinical Immunology (EAACI) Reactions to Food Subcommittee. Allergy. 1999 Jan;54(1):27-45. Bellegrandi S, Rosso R, Mattiacci G, Zaffiro A, Di Sora F, Menzella F, Aiuti F, Paganelli R. Combined immediate- and delayed-type hypersensitivity to metamizole. Allergy. 1999 Jan;54(1):88-90. Bellegrandi S, Rosso R, Mattiacci G, Ferrara R, D'Offizi G, Aiuti F, Mezzaroma I, Paganelli R. Contact dermatitis in subjects infected with HIV type 1. J Am Acad Dermatol. 1999 May;40(5 Pt 1):777-9. Gerli R, Paganelli R, Cossarizza A, Muscat C, Piccolo G, Barbieri D, Mariotti S, Monti D, Bistoni O, Raiola E, Venanzi FM, Bertotto A, Franceschi C. Long-term immunologic effects of thymectomy in patients with myasthenia gravis. J Allergy Clin Immunol. 1999 May;103(5 Pt 1):865-72. Bellioni-Businco B, Paganelli R, Lucenti P, Giampietro PG, Perborn H, Businco L. Allergenicity of goat's milk in children with cow's milk allergy. J Allergy Clin Immunol. 1999 Jun;103(6):1191-4. Mezzaroma I, Carlesimo M, Pinter E, Alario C, Sacco G, Muratori DS, Bernardi ML, Paganelli R, Aiuti F. Long-term evaluation of T-cell subsets and T-cell function after HAART in advanced stage HIV-1 disease. AIDS. 1999 Jul 9;13(10):1187-93. Fabrizi G, Romano A, Vultaggio P, Bellegrandi S, Paganelli R, Venuti A. Heterogeneity of atopic dermatitis defined by the immune response to inhalant and food allergens. Eur J Dermatol. 1999 Jul-Aug;9(5):380-4. 120: Paganelli R, Mezzaroma I, Mazzone AM, Pinter E, Aiuti F. Leptin levels in HIV-positive patients treated with HAART. AIDS. 1999 Dec 3;13(17):2479. Giovannetti A, Pierdominici M, Mazzetta F, Mazzone AM, Ricci G, Prozzo A, Pandolfi F, Paganelli R, Aiuti F. HIV type 1-induced inhibition of CD45 tyrosine phosphatase activity correlates with disease progression and apoptosis, but not with anti-CD3-induced T cell proliferation. AIDS Res Hum Retroviruses. 2000 Feb 10;16(3):211-9. Bagnara GP, Bonsi L, Strippoli P, Bonifazi F, Tonelli R, D'Addato S, Paganelli R, Scala E, Fagiolo U, Monti D, Cossarizza A, Bonafé M, Franceschi C. Hemopoiesis in healthy old people and centenarians: well-maintained responsiveness of CD34+ cells to hemopoietic growth factors and remodeling of cytokine network. J Gerontol A Biol Sci Med Sci. 2000 Feb;55(2):B61-6; discussion B67-70. Cossarizza A, Stent G, Mussini C, Paganelli R, Borghi V, Nuzzo C, Pinti M, Pedrazzi J, Benatti F, Esposito R, Røsok B, Nagata S, Vella S, Franceschi C, De Rienzo B. Deregulation of the CD95/CD95L system in lymphocytes from patients with primary acute HIV infection. AIDS. 2000 Mar 10;14(4):345-55. Rosso R, Mattiacci G, Bernardi ML, Guazzi V, Zaffiro A, Bellegrandi S, De Rocco MG, Bellioni-Businco B, Sirianni MC, Aiuti F, Paganelli R. Very delayed reactions to beta-lactam antibiotics. Contact Dermatitis. 2000 May;42(5):293-5. Carbonari M, Tedesco T, Del Porto P, Paganelli R, Fiorilli M. Human T cells with a type-2 cytokine profile are resistant to apoptosis induced by primary activation: consequences for immunopathogenesis. Clin Exp Immunol. 2000 Jun;120(3):454-62. Gerli R, Monti D, Bistoni O, Mazzone AM, Peri G, Cossarizza A, Di Gioacchino M, Cesarotti ME, Doni A, Mantovani A, Franceschi C, Paganelli R. Chemokines, sTNF-Rs and sCD30 serum levels in healthy aged people and centenarians. Mech Ageing Dev. 2000 Dec 20;121(1-3):37-46. Propato A, Schiaffella E, Vicenzi E, Francavilla V, Baloni L, Paroli M, Finocchi L, Tanigaki N, Ghezzi S, Ferrara R, Chesnut R, Livingston B, Sette A, Paganelli R, Aiuti F, Poli G, Barnaba V. Spreading of HIV-specific CD8+ T-cell repertoire in long-term nonprogressors and its role in the control of viral load and disease activity. Hum Immunol. 2001 Jun;62(6):561-76. Boscol P, Di Sciascio MB, D'Ostilio S, Del Signore A, Reale M, Conti P, Bavazzano P, Paganelli R, Di Gioacchino M. Effects of electromagnetic fields produced by radiotelevision broadcasting stations on the immune system of women. Sci Total Environ. 2001 Jun 12;273(1-3):1-10. Bellioni Businco B, Paganelli R, Bruno G, Grossi O, Di Rienzo A, Businco L. Allergy to tetanus toxoid vaccine. Allergy. 2001 Jul;56(7):701-2. Paganelli R, Di Iorio A, Patricelli L, Ripani F, Sparvieri E, Faricelli R, Iarlori C, Porreca E, Di Gioacchino M, Abate G. Proinflammatory cytokines in sera of elderly patients with dementia: levels in vascular injury are higher than those of mild-moderate Alzheimer's disease patients. Exp Gerontol. 2002 Jan-Mar;37(2-3):257-63. Di Gioacchino M, Masci S, Paolini F, Verna N, Angelucci D, Cavallucci E, Paganelli R. Common variable immunodeficiency and eosinophilic fasciitis. Eur J Dermatol. 2002 Jan-Feb;12(1):73-4. Straface E, Rivabene R, Masella R, Santulli M, Paganelli R, Malorni W. Structural changes of the erythrocyte as a marker of non-insulin-dependent diabetes: protective effects of N-acetylcysteine. Biochem Biophys Res Commun. 2002 Feb 8;290(5):1393-8. doi: 10.1006/bbrc.2002.6340. PMID: 11820776. Di Stefano F, Paganelli R, Verna N, Di Gioacchino M. Cardiac sarcoidosis presenting as Heerfordt's syndrome. Am J Med. 2002 May;112(7):594-5. Di Gioacchino M, Sabbioni E, Di Giampaolo L, Schiavone C, Di Sciascio MB, Reale M, Nicola V, Qiao N, Paganelli R, Conti P, Boscolo P. In vitro effects of vanadate on human immune functions. Ann Clin Lab Sci. 2002 Spring;32(2):148-54. Rabinovich GA, Baum LG, Tinari N, Paganelli R, Natoli C, Liu FT, Iacobelli S. Galectins and their ligands: amplifiers, silencers or tuners of the inflammatory response? Trends Immunol. 2002 Jun;23(6):313-20. Paganelli R, Ciuffreda S, Verna N, Cavallucci E, Paolini F, Ramondo S, Di Gioacchino M. Probiotics and food-allergic diseases. Allergy. 2002;57 Suppl 72:97-9. Ensoli F, Fiorelli V, Lugaresi A, Farina D, De Cristofaro M, Collacchi B, Muratori DS, Scala E, Di Gioacchino M, Paganelli R, Aiuti F. Lymphomononuclear cells from multiple sclerosis patients spontaneously produce high levels of oncostatin M, tumor necrosis factors alpha and beta, and interferon gamma. Mult Scler. 2002 Aug;8(4):284-8. Trubiani O, Di Giulio C, Tripodi D, Bianchi G, Paganelli R, Di Primio R. Thymic sensitivity to hypoxic condition in young and old rats. Age-dependent expression of NF-kappaB. Exp Gerontol. 2002 Aug-Sep;37(8-9):1077-88. Trubiani O, Guarnieri S, Paganelli R, Di Primio R. Involvement of caspace-3 in the cleavage of terminal transferase. Int J Immunopathol Pharmacol. 2002 Sep- Dec;15(3):201-208. 140: Camera E, Lisby S, Dell'Anna ML, Santucci B, Paganelli R, Baadsgaard O, Picardo M. Levels of enzymatic antioxidants activities in mononuclear cells and skin reactivity to sodium dodecyl sulphate. Int J Immunopathol Pharmacol. 2003 Jan-Apr;16(1):49-54. Di Gioacchino M, Verna N, Cavallucci E, Paolini F, Caruso R, Grana M, Schiavone C, Di Iorio A, Ramondo S, Reale M, Paganelli R, Theoharides TC. Steroid and antihistamines modulate RANTES release in cultured peripheral blood mononuclear cells of atopic patients. Int J Immunopathol Pharmacol. 2002 Jan- Apr;15(1):27-34. Vecchiet J, Dalessandro M, Falasca K, Di Iorio A, Travasi F, Zingariello P, Schiavone C, Ensoli F, Pizzigallo E, Paganelli R. Increased production of oncostatin-M by lymphomononuclear cells from HIV-1-infected patients with neuroAIDS. J Acquir Immune Defic Syndr. 2003 Apr 1;32(4):464-5. Vecchiet J, Dalessandro M, Travasi F, Falasca K, Di Iorio A, Schiavone C, Zingariello P, Di Ilio E, Pizzigallo E, Paganelli R. Interleukin-4 and interferon-gamma production during HIV-1 infection and changes induced by antiretroviral therapy. Int J Immunopathol Pharmacol. 2003 May-Aug;16(2):157-66. Boscolo P, del Signore A, Sabbioni E, Di Gioacchino M, Di Giampaolo L, Reale M, Conti P, Paganelli R, Giaccio M. Effects of resveratrol on lymphocyte proliferation and cytokine release. Ann Clin Lab Sci. 2003 Spring;33(2):226-31. Di Iorio A, Ferrucci L, Sparvieri E, Cherubini A, Volpato S, Corsi A, Bonafè M, Franceschi C, Abate G, Paganelli R. Serum IL-1beta levels in health and disease: a population-based study. 'The InCHIANTI study'. Cytokine. 2003 Jun 21;22(6):198-205. Söderström L, Kober A, Ahlstedt S, de Groot H, Lange CE, Paganelli R, Roovers MH, Sastre J. A further evaluation of the clinical use of specific IgE antibody testing in allergic diseases. Allergy. 2003 Sep;58(9):921-8. Di Gioacchino M, Di Stefano F, Cavallucci E, Verna N, Ramondo S, Paolini F, Caruso R, Schiavone C, Masci S, Santucci B, Paganelli R, Conti P. Treatment of chronic idiopathic urticaria and positive autologous serum skin test with cyclosporine: clinical and immunological evaluation. Allergy Asthma Proc. 2003 Jul-Aug;24(4):285-90. Paganelli R, Buttari B, Camera E, Dell'Anna ML, Mastrofrancesco A, Di Giampaolo L, Reale M, Schiavone C, Verna N, Di Gioacchino M, Sabbioni E, Boscolo P, Picardo M. In vitro effects of nickel-sulphate on immune functions of normal and nickel-allergic subjects: a regulatory role for zinc. J Trace Elem Med Biol. 2003;17 Suppl 1:11-5. Pinti M, Biswas P, Troiano L, Nasi M, Ferraresi R, Mussini C, Vecchiet J, Esposito R, Paganelli R, Cossarizza A. Different sensitivity to apoptosis in cells of monocytic or lymphocytic origin chronically infected with human immunodeficiency virus type-1. Exp Biol Med (Maywood). 2003 Dec;228(11):1346-54. Paganelli RA, Benetolli A, Lima KC, Cestari-Junior LA, Favero Filho LA, Milani H. A novel version of the 8-arm radial maze: effects of cerebral ischemia on learning and memory. J Neurosci Methods. 2004 Jan 15;132(1):9-18. Lugaresi A, Di Iorio A, Iarlori C, Reale M, De Luca G, Sparvieri E, Michetti A, Conti P, Gambi D, Abate G, Paganelli R. IL-4 in vitro production is upregulated in Alzheimer's disease patients treated with acetylcholinesterase inhibitors. Exp Gerontol. 2004 Apr;39(4):653-7. Di Gioacchino M, Di Giampaolo L, Verna N, Reale M, Di Sciascio MB, Volpe AR, Carmignani M, Ponti J, Paganelli R, Sabbioni E, Boscolo P. In vitro effects of platinum compounds on lymphocyte proliferation and cytokine release. Ann Clin Lab Sci. 2004 Spring;34(2):195-202. Racciatti D, Dalessandro M, Delle Donne L, Falasca K, Zingariello P, Paganelli R, Pizzigallo E, Vecchiet J. Study of immune alterations in patients with chronic fatigue syndrome with different etiologies. Int J Immunopathol Pharmacol. 2004 May-Aug;17(2 Suppl):57-62. Di Giampaolo L, Di Gioacchino M, Ponti J, Sabbioni E, Castellani ML, Reale M, Toto E, Verna N, Conti P, Paganelli R, Boscolo P. "In vitro" comparative immune effects of different titanium compounds. Int J Immunopathol Pharmacol. 2004 May-Aug;17(2 Suppl):115-22. Boscolo P, Di Giampaolo L, Reale M, Castellani ML, Ritavolpe A, Carmignani M, Ponti J, Paganelli R, Sabbioni E, Conti P, Di Gioacchino M. Different effects of platinum, palladium, and rhodium salts on lymphocyte proliferation and cytokine release. Ann Clin Lab Sci. 2004 Summer;34(3):299-306. Scala E, Pallotta S, Frezzolini A, Abeni D, Barbieri C, Sampogna F, De Pità O, Puddu P, Paganelli R, Russo G. Cytokine and chemokine levels in systemic sclerosis: relationship with cutaneous and internal organ involvement. Clin Exp Immunol. 2004 Dec;138(3):540-6. Scala E, Paganelli R, Sampogna F, Abeni D, Colonna L, De Pità O, Puddu P, Russo G. Alpha4beta1 and alpha4beta7 CD4 T cell numbers increase and CLA CD4 T cell numbers decrease in systemic sclerosis. Clin Exp Immunol. 2005 Mar;139(3):551-7. 160: Boscolo P, Di Giampaolo L, Qiao N, Reale M, Castellani ML, Lucci I, Travaglini P, Kouri M, Verna N, Volpe AR, Carmignani M, Paganelli R, Di Gioacchino M. Inhibitory effects of cadmium on peripheral blood mononuclear cell proliferation and cytokine release are reversed by zinc and selenium salts. Ann Clin Lab Sci. 2005 Spring;35(2):115-20. Di Iorio A, Cherubini A, Volpato S, Sparvieri E, Lauretani F, Franceschi C, Senin U, Abate G, Paganelli R, Martin A, Andres-Lacueva C, Ferrucci L. Markers of inflammation, vitamin E and peripheral nervous system function: the InCHIANTI study. Neurobiol Aging. 2006 Sep;27(9):1280-8. Ciabattoni G, Porreca E, Di Febbo C, Di Iorio A, Paganelli R, Bucciarelli T, Pescara L, Del Re L, Giusti C, Falco A, Sau A, Patrono C, Davì G. Determinants of platelet activation in Alzheimer's disease. Neurobiol Aging. 2007 Mar;28(3):336-42. Paganelli R, Di Iorio A, Cherubini A, Lauretani F, Mussi C, Volpato S, Abate M, Abate G, Ferrucci L. Frailty of older age: the role of the endocrine-- immune interaction. Curr Pharm Des. 2006;12(24):3147-59. Paganelli RA, Benetoli A, Milani H. Sustained neuroprotection and facilitation of behavioral recovery by the Ginkgo biloba extract, EGb 761, after transient forebrain ischemia in rats. Behav Brain Res. 2006 Nov 1;174(1):70-7. Abate M, Di Iorio A, Di Renzo D, Paganelli R, Saggini R, Abate G. Frailty in the elderly: the physical dimension. Eura Medicophys. 2007 Sep;43(3):407-15. Di Iorio A, Abate M, Di Renzo D, Russolillo A, Battaglini C, Ripari P, Saggini R, Paganelli R, Abate G. Sarcopenia: age-related skeletal muscle changes from determinants to physical disability. Int J Immunopathol Pharmacol. 2006 Oct-Dec;19(4):703-19. Giovannetti A, Pierdominici M, Mazzetta F, Marziali M, Renzi C, Mileo AM, De Felice M, Mora B, Esposito A, Carello R, Pizzuti A, Paggi MG, Paganelli R, Malorni W, Aiuti F. Unravelling the complexity of T cell abnormalities in common variable immunodeficiency. J Immunol. 2007 Mar 15;178(6):3932-43. D'Offizi G, Gioia C, Corpolongo A, Martini F, Paganelli R, Volpi I, Sacchi A, Tozzi V, Narciso P, Poccia F. An IL-15 dependent CD8 T cell response to selected HIV epitopes is related to viral control in early-treated HIV-infected subjects. Int J Immunopathol Pharmacol. 2007 Jul-Sep;20(3):473-85. Trubiani O, Isgro A, Zini N, Antonucci I, Aiuti F, Di Primio R, Nanci A, Caputi S, Paganelli R. Functional interleukin-7/interleukin-7Ralpha, and SDF-1alpha/CXCR4 are expressed by human periodontal ligament derived mesenchymal stem cells. J Cell Physiol. 2008 Mar;214(3):706-13. Giovannetti A, Pierdominici M, Di Iorio A, Cianci R, Murdaca G, Puppo F, Pandolfi F, Paganelli R. Apoptosis in the homeostasis of the immune system and in human immune mediated diseases. Curr Pharm Des. 2008;14(3):253-68. Baldoni L, De Simone P, Paganelli R, Traballoni L, Elisei M, Bindi L, Ducci J, Carrai P, Bisá M, Coletti L, Petruccelli S, Masetti M, Padovan A, Coscetti F, Filipponi F. The "You Are Not Alone" care program for liver transplantation. Transplant Proc. 2008 Jul-Aug;40(6):1983-5. Corder EH, Paganelli R, Giunta S, Franceschi C. Differential course of HIV-1 infection and APOE polymorphism. Proc Natl Acad Sci U S A. 2008 Nov 18;105(46):E87. Soresina A, Nacinovich R, Bomba M, Cassani M, Molinaro A, Sciotto A, Martino S, Cardinale F, De Mattia D, Putti C, Dellepiane RM, Felici L, Parrinello G, Neri F, Plebani A; Italian Network for Primary Immunodeficiencies. The quality of life of children and adolescents with X-linked agammaglobulinemia. J Clin Immunol. 2009 Jul;29(4):501-7. Abate M, Silbernagel KG, Siljeholm C, Di Iorio A, De Amicis D, Salini V, Werner S, Paganelli R. Pathogenesis of tendinopathies: inflammation or degeneration? Arthritis Res Ther. 2009;11(3):235. Turi MC, D'Urbano M, Celletti E, Alessandri C, Valesini G, Paganelli R. Serum sFas/sFasL ratio in systemic lupus erythematosus (SLE) is a function of age. Arch Gerontol Geriatr. 2009;49 Suppl 1:221-6. Santoro A, Siviero P, Minicuci N, Bellavista E, Mishto M, Olivieri F, Marchegiani F, Chiamenti AM, Benussi L, Ghidoni R, Nacmias B, Bagnoli S, Ginestroni A, Scarpino O, Feraco E, Gianni W, Cruciani G, Paganelli R, Di Iorio A, Scognamiglio M, Grimaldi LM, Gabelli C, Sorbi S, Binetti G, Crepaldi G, Franceschi C. Effects of donepezil, galantamine and rivastigmine in 938 Italian patients with Alzheimer's disease: a prospective, observational study. CNS Drugs. 2010 Feb;24(2):163-76. Trubiani O, Zalzal SF, Paganelli R, Marchisio M, Giancola R, Pizzicannella J, Bühring HJ, Piattelli M, Caputi S, Nanci A. Expression profile of the embryonic markers nanog, OCT-4, SSEA-1, SSEA-4, and frizzled-9 receptor in human periodontal ligament mesenchymal stem cells. J Cell Physiol. 2010 Oct;225(1):123-31. Petrarca C, Clemente E, Toto V, Iezzi M, Rossi C, Zanotta S, Mistrello G, Zanoni I, Granucci F, Arioli S, Mora D, Guglielmetti S, Paganelli R, Di Gioacchino M. rBet v 1 immunotherapy of sensitized mice with Streptococcus thermophilus as vehicle and adjuvant. Hum Vaccin Immunother. 2014;10(5):1228-37. Cancrini C, Puliafito P, Digilio MC, Soresina A, Martino S, Rondelli R, Consolini R, Ruga EM, Cardinale F, Finocchi A, Romiti ML, Martire B, Bacchetta R, Albano V, Carotti A, Specchia F, Montin D, Cirillo E, Cocchi G, Trizzino A, Bossi G, Milanesi O, Azzari C, Corsello G, Pignata C, Aiuti A, Pietrogrande MC, Marino B, Ugazio AG, Plebani A, Rossi P; Italian Network for Primary Immunodeficiencies. Clinical features and follow-up in patients with 22q11.2 deletion syndrome. J Pediatr. 2014 Jun;164(6):1475-80.e2. Vultaggio A, Azzari C, Milito C, Finocchi A, Toppino C, Spadaro G, Trizzino A, Baldassarre M, Paganelli R, Moschese V, Soresina A, Matucci A. Subcutaneous immunoglobulin replacement therapy in patients with primary immunodeficiency in routine clinical practice: the VISPO prospective multicenter study. Clin Drug Investig. 2015 Mar;35(3):179-85. Ciavarella S, Caselli A, Tamma AV, Savonarola A, Loverro G, Paganelli R, Tucci M, Silvestris F. A peculiar molecular profile of umbilical cord- mesenchymal stromal cells drives their inhibitory effects on multiple myeloma cell growth and tumor progression. Stem Cells Dev. 2015 Jun 15;24(12):1457-70. doi: 10.1089/scd.2014.0254. Epub 2015 Mar 11. PMID: 25758779; PMCID: PMC4485370. 180: Scala E, Till SJ, Asero R, Abeni D, Guerra EC, Pirrotta L, Paganelli R, Pomponi D, Giani M, De Pità O, Cecchi L. Lipid transfer protein sensitization: reactivity profiles and clinical risk assessment in an Italian cohort. Allergy. 2015 Aug;70(8):933-43. doi: 10.1111/all.12635. Epub 2015 May 7. PMID: 25903791. Scichilone N, Ventura MT, Bonini M, Braido F, Bucca C, Caminati M, Del Giacco S, Heffler E, Lombardi C, Matucci A, Milanese M, Paganelli R, Passalacqua G, Patella V, Ridolo E, Rolla G, Rossi O, Schiavino D, Senna G, Steinhilber G, Vultaggio A, Canonica G. Choosing wisely: practical considerations on treatment efficacy and safety of asthma in the elderly. Clin Mol Allergy. 2015 Jun 22;13(1):7. Petrarca C, Clemente E, Amato V, Pedata P, Sabbioni E, Bernardini G, Iavicoli I, Cortese S, Niu Q, Otsuki T, Paganelli R, Di Gioacchino M. Engineered metal based nanoparticles and innate immunity. Clin Mol Allergy. 2015 Jul 15;13(1):13. Scala E, Abeni D, Pomponi D, Paganelli R, Locanto M, Giani M, Cecchi L, Asero R. Ole e 1, Ole e 7, and Ole e 9: Identifying distinct clinical subsets of olive tree-allergic patients. J Allergy Clin Immunol. 2016 Feb;137(2):629-631.e3. Macchia D, Melioli G, Pravettoni V, Nucera E, Piantanida M, Caminati M, Campochiaro C, Yacoub MR, Schiavino D, Paganelli R, Di Gioacchino M; Food Allergy Study Group (ATI) of the Italian Society of Allergy, Asthma and Clinical Immunology (SIAAIC). Guidelines for the use and interpretation of diagnostic methods in adult food allergy. Clin Mol Allergy. 2015 Oct 5;13:27. doi: 10.1186/s12948-015-0033-9. Macchia D, Melioli G, Pravettoni V, Nucera E, Piantanida M, Caminati M, Campochiaro C, Yacoub MR, Schiavino D, Paganelli R, Di Gioacchino M; Food Allergy Study Group (ATI) of the Italian Society of Allergy, Asthma and Clinical Immunology (SIAAIC). Erratum to: Guidelines for the use and interpretation of diagnostic methods in adult food allergy. Clin Mol Allergy. 2015 Dec 21;13:31. Erratum for: Clin Mol Allergy. 2015;13:27. Cortese S, Gatta A, Della Valle L, Mangifesta R, Di Giampaolo L, Cavallucci E, Petrarca C, Paganelli R, Di Gioacchino M. Fluticasone/formoterol association favors long-lasting decrease in bronchial reactivity to methacholine and weekly PEF variability. Int J Immunopathol Pharmacol. 2016 Dec;29(4):769-774. Petrarca C, Clemente E, Amato V, Gatta A, Cortese S, Lamolinara A, Rossi C, Zanotta S, Mistrello G, Paganelli R, Di Gioacchino M. Vitamin D3 improves the effects of low dose Der p 2 allergoid treatment in Der p 2 sensitized BALB/c mice. Clin Mol Allergy. 2016 Aug 5;14:7. Ventura MT, Scichilone N, Paganelli R, Minciullo PL, Patella V, Bonini M, Passalacqua G, Lombardi C, Simioni L, Ridolo E, Del Giacco SR, Gangemi S, Canonica GW. Allergic diseases in the elderly: biological characteristics and main immunological and non-immunological mechanisms. Clin Mol Allergy. 2017 Feb 3;15:2. Rossi AP, Budui S, Zoico E, Caliari C, Mazzali G, Fantin F, D'Urbano M, Paganelli R, Zamboni M. Role of Anti-Inflammatory Cytokines on Muscle Mass and Performance Changes in Elderly Men and Women. J Frailty Aging. 2017;6(2):65-71. Frasca D, Blomberg BB, Paganelli R. Aging, Obesity, and Inflammatory Age- Related Diseases. Front Immunol. 2017 Dec 7;8:1745. Paganelli R, Petrarca C, Di Gioacchino M. Biological clocks: their relevance to immune-allergic diseases. Clin Mol Allergy. 2018 Jan 10;16:1. Gatta A, Della Valle L, Farinelli A, Cavallucci E, Paganelli R, Di Gioacchino M. Omalizumab in chronic spontaneous urticaria: steroid sparing effect. J Dermatolog Treat. 2018;29(sup3):6-9. El-Sayed ZA, Abramova I, Aldave JC, Al-Herz W, Bezrodnik L, Boukari R, Bousfiha AA, Cancrini C, Condino-Neto A, Dbaibo G, Derfalvi B, Dogu F, Edgar JDM, Eley B, El-Owaidy RH, Espinosa-Padilla SE, Galal N, Haerynck F, Hanna-Wakim R, Hossny E, Ikinciogullari A, Kamal E, Kanegane H, Kechout N, Lau YL, Morio T, Moschese V, Neves JF, Ouederni M, Paganelli R, Paris K, Pignata C, Plebani A, Qamar FN, Qureshi S, Radhakrishnan N, Rezaei N, Rosario N, Routes J, Sanchez B, Sediva A, Seppanen MR, Serrano EG, Shcherbina A, Singh S, Siniah S, Spadaro G, Tang M, Vinet AM, Volokha A, Sullivan KE. X-linked agammaglobulinemia (XLA):Phenotype, diagnosis, and therapeutic challenges around the world. World Allergy Organ J. 2019 Mar 22;12(3):100018. Trubiani O, Pizzicannella J, Caputi S, Marchisio M, Mazzon E, Paganelli R, Paganelli A, Diomede F. Periodontal Ligament Stem Cells: Current Knowledge and Future Perspectives. Stem Cells Dev. 2019 Aug 1;28(15):995-1003. Di Giampaolo L, Di Gioacchino M, Mangifesta R, Gatta A, Tinari N, Grassadonia A, Niu Q, Paganelli R, Sabbioni E, Otsuki T, Petrarca C. Occupational allergy: is there a role for nanoparticles? J Biol Regul Homeost Agents. 2019 May-Jun,;33(3):661-668. Di Iorio A, Di Blasio A, Napolitano G, Ripari P, Paganelli R, Cipollone F. High fat mass, low muscle mass, and arterial stiffness in a population of free- living healthy subjects: The "al passo con la tua salute" project. Medicine (Baltimore). 2019 Jun;98(26):e16172. Forlani D, Scarano G, D'Alleva A, Di Marco M, Paloscia L, Gatta A, Della Valle L, Farinelli A, Lumaca A, Petrarca C, Paganelli R, Di Giampaolo L, Di Gioacchino M. Kounis Syndrome as First Manifestation of Allergic Sensitization. Case Rep Med. 2019 Jun 25;2019:6317956. Paganelli A, Garbarino F, Toto P, Martino GD, D'Urbano M, Auriemma M, Giovanni PD, Panarese F, Staniscia T, Amerio P, Paganelli R. Serological landscape of cytokines in cutaneous melanoma. Cancer Biomark. 2019;26(3):333-342. Di Gioacchino M, Petrarca C, Gatta A, Scarano G, Farinelli A, Della Valle L, Lumaca A, Del Biondo P, Paganelli R, Di Giampaolo L. Nanoparticle-based immunotherapy: state of the art and future perspectives. Expert Rev Clin Immunol. 2020 May;16(5):513-525. 200: Della Valle L, Gatta A, Farinelli A, Scarano G, Lumaca A, Tinari N, Cipollone F, Paganelli R, Di Gioacchino M. Allergooncology: an expanding research area. J Biol Regul Homeost Agents. 2020 Mar-Apr;34(2):319-326. D'Angelo C, Goldeck D, Pawelec G, Gaspari L, Di Iorio A, Paganelli R. Exploratory study on immune phenotypes in Alzheimer's disease and vascular dementia. Eur J Neurol. 2020 Oct;27(10):1887-1894. Gatta A, Della Valle L, Farinelli A, Scarano G, Lumaca A, Cavallucci E, Di Gioacchino M, Paganelli R. Vernal Keratoconjunctivitis: A Case of Anti-IgE Treatment with Short-Lasting Remission. Case Rep Ophthalmol. 2020 Jul 3;11(2):268-275. Di Iorio A, Abate M, Bandinelli S, Barassi G, Cherubini A, Andres-Lacueva C, Zamora-Ros R, Paganelli R, Volpato S, Ferrucci L. Total urinary polyphenols and longitudinal changes of bone properties. The InCHIANTI study. Osteoporos Int. 2021 Feb;32(2):353-362. Lougaris V, Pession A, Baronio M, Soresina A, Rondelli R, Gazzurelli L, Benvenuto A, Martino S, Gattorno M, Biondi A, Zecca M, Marinoni M, Fabio G, Aiuti A, Marseglia G, Putti MC, Agostini C, Lunardi C, Tommasini A, Bertolini P, Gambineri E, Consolini R, Matucci A, Azzari C, Danieli MG, Paganelli R, Duse M, Cancrini C, Moschese V, Chessa L, Spadaro G, Civino A, Vacca A, Cardinale F, Martire B, Carpino L, Trizzino A, Russo G, Cossu F, Badolato R, Pietrogrande MC, Quinti I, Rossi P, Ugazio A, Pignata C, Plebani A. The Italian Registry for Primary Immunodeficiencies (Italian Primary Immunodeficiency Network; IPINet): Twenty Years of Experience (1999-2019). J Clin Immunol. 2020 Oct;40(7):1026-1037. Di Iorio A, Paganelli R, Abate M, Barassi G, Ireland A, Macchi C, Molino- Lova R, Cecchi F. Thyroid hormone signaling is associated with physical performance, muscle mass, and strength in a cohort of oldest-old: results from the Mugello study. Geroscience. 2021 Apr;43(2):1053-1064. Petrarca C, Lanuti P, Petrosino MI, Di Pillo S, Mistrello G, Compalati E, Otzuki T, Marchisio M, Pierdomenico L, Paganelli R, Di Gioacchino M. Peripheral effector memory regulatory T cells are incremented and functionally enhanced in successful mite monomeric allergoid sublingual immunotherapy. Allergy. 2021 Jul;76(7):2208-2211. Turi MC, Spitaleri F, Gori AM, Parruti G, Rogolino AA, Albani A, Giusti B, Agostinone L, Cesari F, Ranalli P, Pulini S, Di Gioacchino G, Paganelli R, Marcucci R. A case of vaccine-induced immune thrombotic thrombocytopenia with massive artero-venous thrombosis. Blood Transfus. 2021 Jul;19(4):343-346. Lombardi G, Paganelli R, Abate M, Ireland A, Molino-Lova R, Sorbi S, Macchi C, Pellegrino R, Di Iorio A, Cecchi F. Leukocyte-derived ratios are associated with late-life any type dementia: a cross-sectional analysis of the Mugello study. Geroscience. 2021 Dec;43(6):2785-2793. Guagnano MT, D'Angelo C, Caniglia D, Di Giovanni P, Celletti E, Sabatini E, Speranza L, Bucci M, Cipollone F, Paganelli R. Improvement of Inflammation and Pain after Three Months' Exclusion Diet in Rheumatoid Arthritis Patients. Nutrients. 2021 Oct 9;13(10):3535. 210: Paganelli A, Trubiani O, Diomede F, Pisciotta A, Paganelli R. Immunomodulating Profile of Dental Mesenchymal Stromal Cells: A Comprehensive Overview. Front Oral Health. 2021 Mar 31;2:635055. El-Sayed ZA, El-Ghoneimy DH, Ortega-Martell JA, Radwan N, Aldave JC, Al-Herz W, Al-Nesf MA, Condino-Neto A, Cole T, Eley B, Erwa NHH, Espinosa-Padilla S, Faria E, Rosario Filho NA, Fuleihan R, Galal N, Garabedian E, Hintermeyer M, Imai K, Irani C, Kamal E, Kechout N, Klocperk A, Levin M, Milota T, Ouederni M, Paganelli R, Pignata C, Qamar FN, Quinti I, Qureshi S, Radhakrishnan N, Rezaei N, Routes J, Singh S, Siniah S, Abdel-Hakam Taha I, Tanno LK, Van Dort B, Volokha A, Sullivan K. Allergic manifestations of inborn errors of immunity and their impact on the diagnosis: A worldwide study. World Allergy Organ J. 2022;15(6):100657. doi: 10.1016/j.waojou.2022.100657 Paganelli R. Resurrecting Epstein-Barr Virus. Pathogens. 2022;11(7):772. doi: 10.3390/pathogens11070772 Scala E, Condorelli AG, Scala A, Caprini E, Didona B, Paganelli R, Castiglia D. IgE Sensitization Profile in Patients with Netherton Syndrome. Int Arch Allergy Immunol. 2022;183(12):1291-1296. doi: 10.1159/000526409 Pellegrino R, Paganelli R, Bandinelli S, Cherubini A, Andrés-Lacueva C, Di Iorio A, Sparvieri E, Zamora-Ros R, Ferrucci L. Urinary and Daily Assumption of Polyphenols and Hip-Fracture Risk: Results from the InCHIANTI Study. Nutrients. 2022;14(22):4754. doi: 10.3390/nu14224754. Scala E, Madonna S, Castiglia D, Scala A, Caprini E, Paganelli R. Multiplex Proteomic Evaluation in Inborn Errors with Deregulated IgE Response. Biomedicines. 2023;11(1):202. doi: 10.3390/biomedicines11010202 Paganelli R, Paganelli A, Pawelec G, Di Iorio A. Natural IgG antibodies to β amyloid are decreased in patients with Parkinson's disease. Immun Ageing. 2023;20(1):13. doi: 10.1186/s12979-023-00336-w. Paganelli A, Diomede F, Marconi GD, Pizzicannella J, Rajan TS, Trubiani O, Paganelli R. Inhibition of LPS-Induced Inflammatory Response of Oral Mesenchymal Stem Cells in the Presence of Galectin-3. Biomedicines. 2023;11(6):1519. doi: 10.3390/biomedicines11061519. Paganelli R, Di Lizia M, D'Urbano M, Gatta A, Paganelli A, Amerio P, Parronchi P. Insights from a Case of Good's Syndrome (Immunodeficiency with Thymoma). Biomedicines. 2023;11(6):1605. doi:10.3390/ biomedicines11061605. Pellegrino R, Paganelli R, Di Iorio A, Bandinelli S, Moretti A, Iolascon G, Sparvieri E, Tarantino D, Ferrucci L. Muscle quality, physical performance, and comorbidity are predicted by circulating procollagen type III N-terminal peptide (P3NP): the InCHIANTI follow-up study. Geroscience. 2023 Aug 2. doi: 10.1007/s11357-023-00894-3. Epub ahead of print. Pellegrino R, Paganelli R, Iorio AD, Bandinelli S, Moretti A, Iolascon G, Sparvieri E, Tarantino D, Ferrucci L. Temporal trends, sex differences, and age-related disease influence in Neutrophil, Lymphocyte count and Neutrophil to Lymphocyte-ratio. Results from InCHIANTI follow-up study. Immun Ageing 2023, in press. h-index (Scopus, 249 publications) = 47 Modena, june 23