Scimeca Manuel

Curriculum

PERSONAL INFORMATION Scimeca Manuel ORCID: 0000-0003-0585-1309 Date of birth: 23/05/1983 Nationality: Italian Bibliometric indices (appendix a: full publication list) Papers 116; Total Citations 2018 (Scopus); h-index 26 (Scopus). NATIONAL SCIENTIFIC HABILITATION (ASN) Associate Professor 06/N1 SCIENZE DELLE PROFESSIONI SANITARIE E DELLE. TECNOLOGIE MEDICHE APPLICATE Associate Professor 05/H2 ISTOLOGIA Associate Professor 06/D3 MALATTIE DEL SANGUE, ONCOLOGIA E REUMATOLOGIA Full Professor 06/N1 SCIENZE DELLE PROFESSIONI SANITARIE E DELLE. TECNOLOGIE MEDICHE APPLICATE • EDUCATION 2015 PhD in Medical Biotechnology and Translational Medicine Faculty of Medicine and Surgery/ Department of Biomedicine and Prevention/ University of Rome Tor Vergata, Italy. 2011 Master Degree in “Medical Biotechnology” Faculty of Medicine and Surgery / University of Rome Tor Vergata, Italy 2009 Degree in “Cellular and Molecular Biology” Faculty of Mathematical, Physical, and Biological Sciences/ University of Rome Tor Vergata, Italy • CURRENT POSITIONS 2022- to date Researcher, University of Rome Tor Vergata 2019 – to date Post-doctoral Fellowships University of Rome Tor Vergata, Italy. 2019 – to date Adjunt Professor at Saint Camillus International University of Health Sciences Via di Sant'Alessandro, 8, 00131 Rome, Italy. 2017 – to date Adjunt Professor at San Raffaele University, Rome Italy Via di Val Cannuta 247, 00166, Rome, Italy • PREVIOUS POSITIONS 2018 – 2019 Post-doctoral Fellowships Department of Biomedicine and Prevention/ University of Rome Tor Vergata, Italy. 2016 – 2018 Post-doctoral Fellowships Centre of Space Biomedicine, University of Rome Tor Vergata, Rome, Italy • AWARDS 2019 Fondazione Umberto Veronesi Fellowship for the project “Nuovi bersagli cellulari delle metastasi ossee da carcionoma mammario” 2017 Best scientific contribution - ORTOMED Congress 2017 “Profilo Cellulare e Molecolare della Sarcopenia nei pazienti Osteoporotici e Osteoartosici”, Firenze, Italy 2016 Grant “GISOOS” (Gruppo Italiano di Studio in Ortopedia dell'Osteoporosi Severa) for the project “The Role of Heavy Metal accumulation in osteoporosis” 2016 Best scientific contribution ORTOMED Congress 2016 "PTX3: un nuovo mediatore del metabolismo osseo e del differenzi amento osteoblastico", Firenze, Italy • SUPERVISION OF GRADUATE STUDENTS AND POSTDOCTORAL FELLOWS 2017 – to date more of 100 Master Students/ San Raffaele University, Via di Val Cannuta 247, 00166, Rome, Italy • REVIEWING ACTIVITIES From 2017 Editorial Board - Journal of Molecular Biology and Biotechnology From 2017 Editorial Board - Letters In Health and Biological Sciences From 2020 Editorial Board – International Journal of Molecular Science -MDPI From 2018 Guest Editor for the special issue “Molecular Imaging for Basic Science and Personalized and Intelligent Medicine” – Contrast Media and Molecular Imaging From 2019 Guest Editor for the special issue “Deep Learning as a Gateway to Predictive, Preventive, Personalized, and Participatory Medicine” - Computational and Mathematical Methods in Medicine From 2019 Guest Editor for the special issue “Precision Medicine in Breast Cancer: from Biological Imaging to Artificial Intelligence” – Seminars in Cancer Biology From 2020 Guest Editor for the special issue “Imaging Diagnostics and Pathology in SARS-CoV-2-Related Diseases” – International Journal of Molecular Science – MDPI From 2020 Guest Editor for the special issue “Bone Metastasis Challenge: New Ideas and Future Perspectives” – International Journal of Molecular Science – MDPI From 2020 Guest Editor for the special issue “Calcification in Human Pathology” – International Journal of Molecular Science – MDPI From 2020 Guest Editor for the special issue “Advance in Diagnostic Biomarkers of Human Cancer and Atherosclerosis” – Diagnostics – MDPI From 2020 Guest Editor for the special issue “Easily Accessible Adult Stem Cells: from Bench to Patient and Vice Versa” – Stem Cells International – Hindawi • MEMBERSHIPS OF SCIENTIFIC SOCIETIES 2018 – to date Member of “Società Italiana di Anatomia Patologica (SIAPEC)”, P.zza dell'Ospedale Maggiore, 3 – Milan, Italy 2018 to date Member of “European Society of Pathology”, Rue Bara 6, 1070 Anderlecht, Belgium 2022 to date Member of the SIRTEPS "Società Italiana Ricerca Traslazionale e Professioni Sanitarie" Best 12 Publications 1. Scimeca M, et al. Impairment of PTX3 expression in osteoblasts: a key element for osteoporosis. Cell Death Dis. 2017 Oct 12;8(10):e3125. 2. Scimeca M, et al. Plaque calcification is driven by different mechanisms of mineralization associated with specific cardiovascular risk factors. Nutr Metab Cardiovasc Dis. 2019 Dec;29(12):1330-1336. 3. Scimeca M, et al. Microcalcifications Drive Breast Cancer Occurrence and Development by Macrophage-Mediated Epithelial to Mesenchymal Transition. Int J Mol Sci. 2019 Nov 11;20(22). 4. Rovella V, Anemona L, Cardellini M, Scimeca M, Saggini A, Santeusanio G, Bonanno E, Montanaro M, Legramante IM, Ippoliti A, Di Daniele N, Federici M, Mauriello A. The role of obesity in carotid plaque instability: interaction with age, gender, and cardiovascular risk factors. Cardiovasc Diabetol. 2018 Mar 29;17(1):46. doi: 10.1186/s12933-018-0685-0. 5. Scimeca M, Urbano N, Bonfiglio R, Duggento A, Toschi N, Schillaci O, Bonanno E. Novel insights into breast cancer progression and metastasis: A multidisciplinary opportunity to transition from biology to clinical oncology. Biochim Biophys Acta Rev Cancer. 2019 Aug;1872(1):138-148. 6. Tarantino U, Cariati I, Marini M, D'Arcangelo G, Tancredi V, Primavera M, Iundusi R, Gasbarra E, Scimeca M. Effects of Simulated Microgravity on Muscle Stem Cells Activity. Cell Physiol Biochem. 2020 Aug 5;54(4):736-747. 7. Scimeca M, et al. BMP-2 Variants in Breast Epithelial to Mesenchymal Transition and Microcalcifications Origin. Cells. 2020 Jun 2;9(6):E1381. 8. Scimeca M, et al. Breast cancer metastasis to bone: From epithelial to mesenchymal transition to breast osteoblast-like cells. Semin Cancer Biol. 2020 Feb 8:S1044-579X(20)30005-5. 9. Cardellini M, Rovella V, Scimeca M, Anemona L, Bischetti S, Casella S, Saggini A, Bonanno E, Ballanti M, Davato F, Menghini R, Ippoliti A, Santeusanio G, Di Daniele N, Federici M, Mauriello A. Chronic Kidney Disease Is Linked to Carotid Nodular Calcification, An Unstable Plaque Not Correlated to Inflammation. Aging Dis. 2019 Feb 1;10(1):71-81. 10. Scimeca M, et al. Vitamin D Receptor in Muscle Atrophy of Elderly Patients: A Key Element of Osteoporosis-Sarcopenia Connection. Aging Dis. 2018 Dec 4;9(6):952-964. 11. Di Leo L, Vegliante R, Ciccarone F, Salvatori I, Scimeca M, Bonanno E, Sagnotta A, Grazi GL, Aquilano K, Ciriolo MR. Forcing ATGL expression in hepatocarcinoma cells imposes glycolytic rewiring through PPAR-α/p300-mediated acetylation of p53. Oncogene. 2019 Mar;38(11):1860-1875. 12. Sandonà M, Consalvi S, Tucciarone L, De Bardi M, Scimeca M, Angelini DF, Buffa V, D'Amico A, Bertini ES, Cazzaniga S, Bettica P, Bouché M, Bongiovanni A, Puri PL, Saccone V. HDAC inhibitors tune miRNAs in extracellular vesicles of dystrophic muscle-resident mesenchymal cells. EMBO Rep. 2020 Sep 3;21(9):e50863. Co-Founder of Spin-off “TMALab S.r.l.” at University of Rome Tor Vergata, Rome, Italy. The main activity of the the TMALab S.r.l. is the design, production and distribution of TMA (Tissue Micro Array or Textile Matrix) which represent a highly innovative tool for providing biomedical basic and translational research for validation studies on human tissues of diagnostic and / or predictive biomarkers of response to a particular therapy. Co-Founder of OrchidealLab S.r.l.”, Rome, Italy. OrchideaLab S.r.l. collaborate with multinational companies with whom it participates to develop new devices and guidelines to improve the service offered to Patients and Operators in the field of histology and molecular biology. Patents (pending): Brev/gc [A18256-00], it: 102017000081653 SM: SM-P-201700521 - Pentraxin 3 (PTX3) protein for the treatment and in vitro diagnosis of osteoporosis Inventors Dr. Manuel Scimeca – Prof. Umberto Tarantino