Galardi Silvia

Docente a contratto esterno 
Scientific Disciplinary Sector Code BIOLOGIA APPLICATA (BIO/13)
University Università degli Studi di ROMA "Tor Vergata" 
College/Department Department  Facoltà dipartimentale di Medicina 

Reception times

Lunedi, 15-16 Monday 15-16

Curriculum

Education and qualification 2002 PhD in Genetics and Molecular Biology. University “la Sapienza”, Rome, Italy. 1999 Master Degree with honours in Biological Sciences. University “la Sapienza”, Rome, Italy. Positions and Employment 2002-2004 Post-doctoral research associate at Wellcome Trust Centre for Cell Biology, University of Edinburgh, UK 2004-to present Assistant Professor at University of Rome "Tor Vergata", Italy Other Professional Experience and Memberships 2000 ICGEB teorical course “RNA Structure and Function”, Trieste-ICGEB 2002 NATO/EMBO/FEBS teorical course “Structure and Function of Macromolecular complexes” Since 2004: Member of the Italian Association of General and Molecular Biology and Genetics, Since 2008: Member of the Italian federation Science of Life 2013: Expert Reviewer for the Wellcome Trust Foundation, Uk 2014: Expert Reviewer, and the Medical Research Council. 2014: member of the jury for the award of the title of PhD in Human Biology and Genetics, at the University "La Sapienza", Rome 2016: Ad Hoc Reviewer, Italian Ministry of Instruction, University and Research 2017: Ad hoc reviewer fot University of Verona, basic research 2017 Honors 1999 Scholarship awarded by the University of Modena 2002 short EMBO fellowship by the European Molecular Biology Organization 2003 Postdoctoral fellowship by the Wellcome Trust Center,UK Research Activity (keywords) Regulation of gene expression RNA metabolism Biosynthesis and function of non coding RNAs (microRNA, snRNA, lncRNA) Cancer stem cells Neural stem cells Brain tumour Last 10 years Publications on International Peer-Reviewed Journals 1. Fazi B, Garbo S, Toschi N, Mangiola A, Lombari M, Sicari D, Battistelli C, Galardi S, Michienzi A, Trevisi G, Harari-Steinfeld R, Cicchini C, Ciafrè SA. The lncRNA H19 positively affects the tumorigenic properties of glioblastoma cells and contributes to NKD1 repression through the recruitment of EZH2 on its promoter. Oncotarget. (2018) Feb 14;9(21):15512-15525 2. Dual regulation of L-selectin (CD62L) by HIV-1: Enhanced expression by Vpr in contrast with cell-surface down-modulation by Nef and Vpu. Giuliani E, Vassena L, Galardi S, Michienzi A, Desimio MG, Doria M. Virology. (2018) Oct;523:121-128 3. Post-transcriptional regulation of LINE-1 retrotransposition by AID/APOBEC and ADAR deaminases. Orecchini E, Frassinelli L, Galardi S, Ciafrè SA, Michienzi A.Chromosome Res. (2018) Mar;26(1-2):45-59. 4. Mercatelli N, Galardi S, Ciafrè SA. MicroRNAs as Multifaceted Players in Glioblastoma Multiforme. Int Rev Cell Mol Biol. (2017);333:269-323. 5. Orecchini E, Doria M, Antonioni A, Galardi S, Ciafrè SA, Frassinelli L, Mancone C, Montaldo C, Tripodi M, Michienzi A. ADAR1 restricts LINE-1 retrotransposition. Nucleic Acids Res. (2017) Jan 9;45(1):155-168. 6. Galardi S, Savino M, Scagnoli F, Pellegatta S, Pisati F, Zambelli F, Illi B, Annibali D, Beji S, Orecchini E, Alberelli MA, Apicella C, Fontanella RA, Michienzi A, Finocchiaro G, Farace MG, Pavesi G, Ciafrè SA, Nasi S. Resetting cancer stem cell regulatory nodes upon MYC inhibition. EMBO Rep. (2016) Dec;17(12):1872-1889. 7. Galardi S, Petretich M, Pinna G, D'Amico S, Loreni F, Michienzi A, Groisman I, Ciafrè SA. CPEB1 restrains proliferation of Glioblastoma cells through the regulation of p27(Kip1) mRNA translation. Sci Rep. (2016) May 4;6:25219. 8. Tomaselli S, Galeano F, Alon S, Raho S, Galardi S, Polito VA, Presutti C, Vincenti S, Eisenberg E, Locatelli F, Gallo A. Modulation of microRNA editing, expression and processing by ADAR2 deaminase in glioblastoma.Genome Biol. (2015) Jan 13;16:5. 9. Orecchini E, Doria M, Michienzi A, Giuliani E, Vassena L, Ciafrè SA, Farace MG, Galardi S. The HIV-1 Tat protein modulates CD4 expression in human T cells through the induction of miR-222. RNA Biol. (2014) ;11(4):334-8. 10. Ciafrè SA, Galardi S. microRNAs and RNA-binding proteins: a complex network of interactions and reciprocal regulations in cancer.. RNA Biol. (2013) Jun;10(6):935-42 11. Galardi S, Mercatelli N, Farace MG, Ciafrè SA. NF-kB and c-Jun induce the expression of the oncogenic miR-221 and miR-222 in prostate carcinoma and glioblastoma cells. Nucleic Acids Res. (2011) May;39(9):3892-902. 12. Evangelisti C, Florian MC, Massimi I, Dominici C, Giannini G, Galardi S, Buè MC, Massalini S, McDowell HP, Messi E, Gulino A, Farace MG, Ciafrè SA. MiR-128 up-regulation inhibits Reelin and DCX expression and reduces neuroblastoma cell motility and invasiveness. (2009) FASEB J. Aug 27. 13. Gallo A, Galardi S. A-to-I RNA editing and cancer: from pathology to basic science. (2008) RNA Biol. Jul-Sep;5(3):135-9. Teaching Activity -aa 1999 / 2000-2001 / 2002: School of Specialization in Biotechnological Applications, University of Rome "La Sapienza" -aa 2005 / 2006-2009 / 2010 holder of the teachings of Cell Biology, Applied Biology and Genetics under the Integrated Course of Biology and Genetics for the Degree Course of Podiatry, University of Rome "Tor Vergata". -aa 2009/2010: holder of the teachings of Cell Biology, Applied Biology of Integrated Course of Biology and Genetics for the Degree course of Physiotherapy, Speech Therapy and Nursing Science at the Foundation of Saint Lucia, Rome -aa 2011/present: holder of the teachings of Cell Biology for the Integrated Course of Biology , Biochemestry and Genetics for the Degree course of Physiotherapy, Podiatry, Orthoptics, Techniques of psychiatric rehabilitation, Techniques of neurophysiopathology at the Univerity of Rome “Tor Vergata” -aa 2008/present: : holder of the teachings of Cell Biology for the Integrated Course of Biology and Genetics for the Degree course of Medicine and Surgery at the University of Tirana “ Nostra Signora del Buon Consiglio” -2001 - present: scientific training and guide the preparation of the thesis of students for the Degree in Medicine and in Biological Sciences.