Sbardella Diego

Docente a contratto esterno 
Settore scientifico disciplinare di riferimento BIOCHIMICA (BIO/10)
Ateneo Università degli Studi di ROMA "Tor Vergata" 
Struttura di afferenza Dipartimento di Facoltà dipartimentale di Medicina 

Orari di ricevimento

Tutti i giovedi dalle ore 12.30 alle ore 15.00 , previo appuntamento via mail

Curriculum

CURRICULUM VITAE Education and Actual Position 2001: High school, diploma “Maturità classica”. 2006: Degree in Medical Biotechnologies at the University of Tor Vergata, Rome, with mark 110/110 cum Laude. 2008: Professional Abilitation to biological public work. 2007-2010: Ph.D. in Biochemistry and Molecular Biology, University of Tor Vergata (Supervisor: prof. Massimo Coletta). 2010-Actual: Fellowship at the laboratory of Stefano Marini 2015: Member of the Steering Board of the CTIF-I (Center for TeleinFrastruktur) 2018: Degree in Medicine and Surgery at the University of Tor Vergata, Rome, with mark 110/110 cum Laude. 2018: National Scientific Habilitation for full professorship (scientific-disciplinary sector: E1-BIO/10) Academic Teaching 2007–2010: Assistant of prof. De Sanctis in the teaching of Molecular Biology at the University of Camerino. 2007-Actual: Assistant of prof. Coletta and prof. Marini in the teaching of Chemistry and Biochemistry (Italian and English courses) at the Tor Vergata University of Rome. 2013-2015: Assistant of prof. Marini in the teaching of Chemistry at the “Madre Teresa del Buon Consiglio” University of Tirana, Albania. 2010–Actual: Assistant of prof. Marini in the teaching of Molecular Biology at the University of Tor Vergata, Rome. 2014-Actual: Professor of Human Anatomy at the Tor Vergata University of Rome (Master Course in Manual Therapy and Physiotherapy). H-Index and Selected Publications H-Index: 11 Publications List Monaco S, Sparano V, Gioia M, Sbardella D, Di Pierro D, Marini S, Coletta M. Enzymatic processing of collagen IV by MMP-2 (gelatinase A) affects neutrophil migration and it is modulated by extracatalytic domains. Protein Sci. 2006. 15:2805-2815 Gioia M, Monaco S, Van Den Steen PE, Sbardella D, Grasso G, Marini S, Overall CM, Opdenakker G, Coletta M. The collagen binding domain of gelatinase A modulates degradation of collagen IV by gelatinase B. J Mol Biol. 2009. 386:419-434 Gioia M, Fasciglione GF, Monaco S, Iundusi R, Sbardella D, Marini S, Tarantino U, Coletta M. pH dependence of the enzymatic processing of collagen I by MMP-1 (fibroblast collagenase), MMP-2 (gelatinase A), and MMP-14 ectodomain. J Biol Inorg Chem. 2010. 15:1219-1232. Bozzi M, Inzitari R, Sbardell D, Monaco S, Pavoni E, Gioia M, Marini S, Morlacchi S, Sciandra F, Castagnola M, Giardina B, Brancaccio A, Coletta M. Enzymatic processing of beta-dystroglycan recombinant ectodomain by MMP-9: identification of the main cleavage site. IUBMB Life. 2009. 61:1143-1152. Ferraris DM, Sbardella D, Petrera A, Marini S, Amstutz B, Coletta M, Sander P, Rizzi M. Crystal structure of Mycobacterium tuberculosis zinc-dependent metalloprotease-1 (Zmp1), a metalloprotease involved in pathogenicity. J Biol Chem. 2011. 286:32475-82. Sbardella D, Fasciglione GF, Gioia M, Ciaccio C, Tundo GR, Marini S, Coletta M. Human matrix metalloproteinases: an ubiquitarian class of enzymes involved in several pathological processes. Mol Aspects Med. 2012. 33:119-208. Tundo G, Ciaccio C, Sbardella D, Boraso M, Viviani B, Coletta M, Marini S. Somatostatin modulates insulin-degrading-enzyme metabolism: implications for the regulation of microglia activity in AD. PLoS One. 2012. 7:e34376. Petrera A, Amstutz B, Gioia M, Hähnlein J, Baici A, Selchow P, Ferraris DM, Rizzi M, Sbardella D, Marini S, Coletta M, Sander P. Functional characterization of the Mycobacterium tuberculosis zinc metallopeptidase Zmp1 and identification of potential substrates. Biol Chem. 2012. 393:631-640. Sbardella D, Inzitari R, Iavarone F, Gioia M, Marini S, Sciandra F, Castagnola M, Van den Steen PE, Opdenakker G, Giardina B, Brancaccio A, Coletta M, Bozzi M. Enzymatic processing by MMP-2 and MMP-9 of wild-type and mutated β-dystroglycan. IUBMB Life. 2012. 64:988-94. Tundo GR, Sbardella D, Ciaccio C, Bianculli A, Orlandi A, Desimio MG, Arcuri G, Coletta M, Marini S. Insulin-degrading enzyme (IDE): a novel heat shock-like protein. J Biol Chem. 2013. 288:2281-2289. Nicolis S, Monzani E, Pezzella A, Ascenzi P, Sbardella D, Casella L. Neuroglobin modification by reactive quinone species. Chem Res Toxicol. 2013. 26:1821-1831. Tomao L, Sbardella D, Gioia M, Di Masi A, Marini S, Ascenzi P, Coletta M. Characterization of the prostate-specific antigen (PSA) catalytic mechanism: a pre-steady-state and steady-state study. PLoS One. 2014. 9:e102470. Ascenzi P, Leboffe L, Pesce A, Ciaccio C, Sbardella D, Bolognesi M, Coletta M. Nitrite-reductase and peroxynitrite isomerization activities of Methanosarcina acetivorans protoglobin. PLoS One. 2014. 9:e95391. Sbardella D., Sciandra F., Gioia M., Marini S., Gori A., Giardina B, Tarantino U, Coletta M, Brancaccio A, Bozzi M. Alpha-Dystroglycan is a Potential Target of Matrix Metalloproteinase MMP-2. Matrix Biology. 2015. 41:2-7. Sbardella D., Marini S., Fasciglione G.F., Gioia M., Tundo G.R., Bisicchia S., Gasbarra E., Ippolito E., Tarantino U., Coletta M. Role of Metalloproteinases in Tendon Physiopathology. Mini Rev. Med. Chem. 2015. 14:978-987. Tundo GR, Sbardella D, De Pascali SA, Ciaccio C, Coletta M, Fanizzi FP, Marini S. Novel Platinum(II) compounds modulate insulin-degrading enzyme activity and induce cell death in neuroblastoma cells. J Biol Inorg Chem. 2015. 20:101-108. Sbardella D, Tundo GR, Sciandra F, Bozzi M, Gioia M, Ciaccio C, Tarantino U, Brancaccio A, Coletta M, Marini S. 26S proteasome activity is modulated by fluctuations in Insulin Degrading Enzyme activity. PlosOne. 2015. 10:e0132455 Sbardella D.*, Tundo G.R.*, Ciaccio C., De Pascali S., Canpanella V., Cozza P., Tarantino U., Coletta., Fanizzi F.P., Marini S. Effect of cisplatin on proteasome activity. J Inorg Biochem. 2015. 153:253-258. * These authors have equally contributed to the study. Ascenzi P., Sbardella D., Fiocchetti M., Santucci R., Coletta M. NO2--mediated nitrosylation of ferrous microperoxidase-11. J Inorg Biochem. 2015, 153:121-127. Santoro A.M., Cunsolo A., D’Urso A., Sbardella D., Tundo G.R., Ciaccio C., Diana D, Fattorusso R., Fattorusso C., Persico M., Di Dato A., Coletta M., Milardi D., Purrello R. Cationic porphyrins are tunable gate-keepers of the 20S proteasome. Chem. Sci. 2016. 7:1286-1297. Tundo GR, Di Muzio E, Ciaccio C, Sbardella D, Di Pierro D, Polticelli F, Coletta M, Marini S. Multiple allosteric sites are involved in the modulation of insulin-degrading-enzyme activity by somatostatin. FEBS J. 2016 283:3755-3770. Ciaccio C, Di Pierro D, Sbardella D, Tundo GR, Curatolo P, Galasso C, Santarone ME, Casasco M, Cozza P, Cortelazzo A, Rossi M, De Felice C, Hayek J, Coletta M, Marini S. Oxygen exchange and energy metabolism in erythrocytes of Rett syndrome and their relationships with respiratory alterations. Mol Cell Biochem. 2017. 426:205-213. Grasso G, Santoro AM, Lanza V, Sbardella D, Tundo GR, Ciaccio C, Marini S, Coletta M, Milardi D The double faced role of copper in Aβ homeostasis: A survey on the interrelationship between metal dyshomeostasis, UPS functioning and autophagy in neurodegeneration. Coord. Chem. Reviews 2017. 437:1-22 Tundo GR, Sbardella D, Ciaccio C, Grasso G, Gioia M, Coletta A, Polticelli F, Di Pierro D, Milardi D, Van Endert P, Marini S, Coletta M. Multiple functions of insulin-degrading enzyme: a metabolic crosslight? Crit Rev Biochem Mol Biol. 2017. 52:554-582. Dato AD, Cunsolo A, Persico M, Santoro AM, D'Urso A, Milardi D, Purrello R, Stefanelli M, Paolesse R, Tundo GR, Sbardella D, Fattorusso C, Coletta M. Electrostatic Map Of Proteasome α-Rings Encodes The Design of Allosteric Porphyrin-Based Inhibitors Able To Affect 20S Conformation By Cooperative Binding. Sci Rep. 2017. 7: 17098. Paolino M, Brindisi M, Vallone A, Butini S, Campiani G, Nannicini C, Giuliani G, Anzini M, Lamponi S, Giorgi G, Sbardella D, Ferraris DM, Marini S, Coletta M, Palucci I, Minerva M, Delogu G, Pepponi I, Goletti D, Cappelli A, Gemma S, Brogi S. Development of Potent Inhibitors of the Mycobacterium tuberculosis Virulence Factor Zmp1 and Evaluation of Their Effect on Mycobacterial Survival inside Macrophages. Chem Med Chem. 2018. 13:422-430. Gioia M, Fasciglione GF, Sbardella D, Sciandra F, Casella M, Camerini S, Crescenzi M, Gori A, Tarantino U, Cozza P, Brancaccio A, Coletta M, Bozzi M. The enzymatic processing of α-dystroglycan by MMP-2 is controlled by two anchoring sites distinct from the active site. PLoS One. 2018. 13:e0192651 Sbardella D, Tundo GR, Campagnolo L, Valacchi G, Orlandi A, Curatolo P, Borsellino G, D'Esposito M, Ciaccio C, Cesare SD, Pierro DD, Galasso C, Santarone ME, Hayek J, Coletta M, Marini S. Retention of Mitochondria in Mature Human Red Blood Cells as the Result of Autophagy Impairment in Rett Syndrome. Sci Rep. 2017. 26:12297. Sbardella D, Tundo GR, Coletta A, Marcoux J, Koufogeorgou EI, Ciaccio C, Santoro AM, Milardi D, Grasso G, Cozza P, Bousquet-Dubouch MP, Marini S, Coletta M. The Insulin Degrading Enzyme is an Allosteric Modulator of the 20S Proteasome and a Potential Competitor of the 19S. Cell Molecular Life Sciences doi: 10.1007/s00018-018-2807-y. Tundo GR, Sbardella D, Coletta M.Insights into Proteasome Conformation Dynamics and Intersubunit Communication. Trends Biochem Sci. 2018 doi: 10.1016/j.tibs.2018.08.002. Conferences and International Courses 2008: International Winter School: “Matrix Metalloproteinases and their inhibitors”, Tiers, Sudtirol, Italy) (speaker). 2010: XXIII FECTS meeting, Davos, Switzerland (poster presenter). 2011: Biomet 2009, Workshop PharmacoBiometallics (C.I.R.C.M.S.B), San Benedetto del Tronto, Italy (speaker). 2012: Convegno Nazionale della Divisione di Chimica dei Sistemi Biologici della Società Chimica Italiana (Convetion of Italian Chemical Society, divison of “Chemistry of biological system”), Napoli, Italy (speaker). 2013: Convegno Nazionale della Divisione di Chimica dei Sistemi Biologici della Società Chimica Italiana (Convetion of Italian Chemical Society, divison of “Chemistry of biological system”), Bertinoro, Italy, (speaker). 2015: Gordon Research Conference, “Stress proteins in Growth Development and Disease”, Barga (LU), Italy, (poster presenter). 2013: Convegno Nazionale della Divisione di Chimica dei Sistemi Biologici della Società Chimica Italiana (Convetion of Italian Chemical Society, divison of “Chemistry of biological system”), Siracusa, Italy, (speaker). 2016: COST Workshop “Proteasome and Autophagy”, Clermont-Ferrand, France, (poster presenter). 2017: IX ZOMES (The Insulin Degrading Enzyme is an Allosteric Modulator of the 20S Proteasome and a Potential Competitor of the 19S) (oral talk), Rome, Italy. 2018: Proteasome Hub 2018, Munchen, Germany (poster presenter) Patents 2017: Methods for the Quick Diagnosis of Rett Syndrome. Patent number: 102016000117469 Achievements: Received “Raeli” Award for best academic achievement (2007).